DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5347 and MKRN3

DIOPT Version :9

Sequence 1:	NP_572970.1	Gene:	CG5347 / 32403	FlyBaseID:	FBgn0030578	Length:	285	Species:	Drosophila melanogaster
Sequence 2:	NP_005655.1	Gene:	MKRN3 / 7681	HGNCID:	7114	Length:	507	Species:	Homo sapiens

Alignment Length:	325	Identity:	131/325 - (40%)
Similarity:	170/325 - (52%)	Gaps:	65/325 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QTICRFHLLGICRFGDLCRFSHD----ETTPNDNQSP-------------QISEIADEVVENEQV 54
            |.|||:::.|.|:.|:.||:|||    :.......||             .|.....||.|....
Human    98 QIICRYYIHGQCKEGENCRYSHDLSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPPA 162

  Fly    55 VASTS-----SYSRQ--------------------MTWANAPEFVP------RYKANS--ADFQA 86
            .:|.|     |.:.:                    .:||:|.||||      |:.|::  |..|:
Human   163 ASSLSLPVIGSAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQS 227

  Fly    87 TE----------GVQDICPYG--GSCIWGSKCSYPLHMEICKMCDLYCLHPMDQNQRRAHNRECL 139
            :|          |:: .|.|.  |.|..|..|.| ||.:||.||.|..|||||..||..|.|.|:
Human   228 SETERKQMAVGSGLR-FCYYASRGVCFRGESCMY-LHGDICDMCGLQTLHPMDAAQREEHMRACI 290

  Fly   140 EQHEQAMELSFAIARSKDKMCGICFDTVVEKKG-RERRFGILSKCKHIFCLTCIRTWRQAHQFEA 203
            |.||:.||||||:.|..||:||||.:.|.||.. .:|||||||.|.|.||:.|||.||.|.|||.
Human   291 EAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFEN 355

  Fly   204 TVTRGCPECRVFSEFVCPSAYWVDTKEEKDKLLSEYRAAMGAKDCKYFNGGLGKCPFGNKCFYRH 268
            .:.:.||:|||.||.|.||.:||:.:|||.||:.:|:.||..|.|:||..|.|.||||:.|||:|
Human   356 RIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKH 420

Fly 269 268
Human 421 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5347	NP_572970.1	ZnF_C3H1	4..30	CDD:214632	12/26 (46%)
		PHA03096	<80..239	CDD:222981	84/173 (49%)
		RING	159..213	CDD:238093	29/54 (54%)
MKRN3	NP_005655.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		DNA_pol3_gamma3	<33..232	CDD:331207	33/133 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..89
		ZnF_C3H1	95..121	CDD:214632	11/22 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..149		2/22 (9%)
		PHA02929	<252..400	CDD:331986	81/148 (55%)
		Makorin-type Cys-His	266..293		15/26 (58%)
		RING-HC_MKRN1_3	308..368	CDD:319644	34/59 (58%)
		RING-HC finger (C3HC4-type)	311..364	CDD:319644	29/52 (56%)
		MKRN1_C	439..505	CDD:318109
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	0.172	Domainoid score	I8156
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3221
Isobase	1	0.950	-	0	Normalized mean entropy	S3270
OMA	1	1.010	-	-		QHG58455
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm8603
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890