DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5347 and MKRN2

DIOPT Version :9

Sequence 1:NP_572970.1 Gene:CG5347 / 32403 FlyBaseID:FBgn0030578 Length:285 Species:Drosophila melanogaster
Sequence 2:NP_054879.3 Gene:MKRN2 / 23609 HGNCID:7113 Length:416 Species:Homo sapiens


Alignment Length:317 Identity:118/317 - (37%)
Similarity:159/317 - (50%) Gaps:54/317 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 RSQTICRFHLLGICRFGDLCRFSHDE----------TTPNDNQSPQI------SEIADEVV---- 49
            :..|||:::..|.|.:|..||:.|..          |..:...||..      ||:...:|    
Human    32 KPSTICKYYQKGYCAYGTRCRYDHTRPSAAAGGAVGTMAHSVPSPAFHSPHPPSEVTASIVKTNS 96

  Fly    50 ------ENEQVVASTSSYSRQMTWANAPEFV------------PRYKANS---------ADFQAT 87
                  |...:|....:.|........|..|            |..|.:|         .|.:|:
Human    97 HEPGKREKRTLVLRDRNLSGMAERKTQPSMVSNPGSCSDPQPSPEMKPHSYLDAIRSGLDDVEAS 161

  Fly    88 EGV---QDICPY--GGSCIWGSKCSYPLHMEICKMCDLYCLHPMDQNQRRAHNRECLEQHEQAME 147
            ...   |.:|||  .|.|.:|..|.| ||.|:|::|.|..|||.|..||:||.:.|:...|..||
Human   162 SSYSNEQQLCPYAAAGECRFGDACVY-LHGEVCEICRLQVLHPFDPEQRKAHEKICMLTFEHEME 225

  Fly   148 LSFAIARSKDKMCGICFDTVVEK-KGRERRFGILSKCKHIFCLTCIRTWRQAHQFEATVTRGCPE 211
            .:||...|:||:|.||.:.::|| ...||||||||.|.|.:||:|||.||.|.|||..:.:.|||
Human   226 KAFAFQASQDKVCSICMEVILEKASASERRFGILSNCNHTYCLSCIRQWRCAKQFENPIIKSCPE 290

  Fly   212 CRVFSEFVCPSAYWVDTKEEKDKLLSEYRAAMGAKDCKYFNGGLGKCPFGNKCFYRH 268
            |||.||||.||.|||:.:.:|::|:..::..||.|.||||..|.|.||||:||.|||
Human   291 CRVISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRH 347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5347NP_572970.1 ZnF_C3H1 4..30 CDD:214632 9/24 (38%)
PHA03096 <80..239 CDD:222981 78/173 (45%)
RING 159..213 CDD:238093 29/54 (54%)
MKRN2NP_054879.3 ZnF_C3H1 2..28 CDD:214632
ZnF_C3H1 35..55 CDD:214632 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 113..142 4/28 (14%)
PHA03096 <178..327 CDD:222981 73/149 (49%)
Makorin-type Cys-His 193..222 12/28 (43%)
RING 238..292 CDD:238093 29/53 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 85 0.172 Domainoid score I8156
eggNOG 1 0.900 - - E1_KOG1039
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 252 1.000 Inparanoid score I3221
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG58455
OrthoDB 1 1.010 - - D1388677at2759
OrthoFinder 1 1.000 - - FOG0000752
OrthoInspector 1 1.000 - - mtm8603
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11224
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2178
SonicParanoid 1 1.000 - - X837
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.970

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