DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5347 and MKRN1

DIOPT Version :9

Sequence 1:NP_572970.1 Gene:CG5347 / 32403 FlyBaseID:FBgn0030578 Length:285 Species:Drosophila melanogaster
Sequence 2:NP_038474.2 Gene:MKRN1 / 23608 HGNCID:7112 Length:482 Species:Homo sapiens


Alignment Length:353 Identity:136/353 - (38%)
Similarity:175/353 - (49%) Gaps:76/353 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 QTICRFHLLGICRFGDLCRFSHD---------------------ETTPNDNQSP--QISEIADEV 48
            |..||:.:.|:|:.||.||:|||                     :....::..|  |....|.|:
Human    58 QVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATEL 122

  Fly    49 VENEQVVASTS---------------SYSRQMT----------WANAPEFVP--RYKANSA---- 82
            .....:.||:|               :.||...          |.||.||||  .|...:|    
Human   123 TTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCT 187

  Fly    83 ---------------DFQATEGVQDICPYG--GSCIWGSKCSYPLHMEICKMCDLYCLHPMDQNQ 130
                           :..|.|..:.:|||.  |.|.:|..|.| ||.:.|.||.|..|||||..|
Human   188 EAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVY-LHGDSCDMCGLQVLHPMDAAQ 251

  Fly   131 RRAHNRECLEQHEQAMELSFAIARSKDKMCGICFDTVVEKKG-RERRFGILSKCKHIFCLTCIRT 194
            |..|.:.|:|.||:.||||||:.||||.:||||.:.|.||.. .||||||||.|.|.:||.|||.
Human   252 RSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRK 316

  Fly   195 WRQAHQFEATVTRGCPECRVFSEFVCPSAYWVDTKEEKDKLLSEYRAAMGAKDCKYFNGGLGKCP 259
            ||.|.|||:.:.:.|||||:.|.||.||.|||:.||||.||:.:|:.||..|.|:||:.|.|.||
Human   317 WRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCP 381

  Fly   260 FGNKCFYRH---HRRCDDNQTQSNAVNS 284
            ||..|||:|   ..|.::.|.|....:|
Human   382 FGGNCFYKHAYPDGRREEPQRQKVGTSS 409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5347NP_572970.1 ZnF_C3H1 4..30 CDD:214632 12/43 (28%)
PHA03096 <80..239 CDD:222981 86/180 (48%)
RING 159..213 CDD:238093 31/54 (57%)
MKRN1NP_038474.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..52
ZnF_C3H1 55..81 CDD:214632 11/22 (50%)
ZnF_C3H1 88..110 CDD:214632 0/21 (0%)
PHA03096 <221..370 CDD:222981 83/149 (56%)
Makorin-type Cys-His 236..263 14/26 (54%)
RING 281..335 CDD:238093 31/53 (58%)
MKRN1_C 400..480 CDD:292443 3/10 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 85 0.172 Domainoid score I8156
eggNOG 1 0.900 - - E1_KOG1039
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H32175
Inparanoid 1 1.050 252 1.000 Inparanoid score I3221
Isobase 1 0.950 - 0 Normalized mean entropy S3270
OMA 1 1.010 - - QHG58455
OrthoDB 1 1.010 - - D1388677at2759
OrthoFinder 1 1.000 - - FOG0000752
OrthoInspector 1 1.000 - - mtm8603
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11224
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2178
SonicParanoid 1 1.000 - - X837
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.920

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