DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5347 and lep-2

DIOPT Version :9

Sequence 1:	NP_572970.1	Gene:	CG5347 / 32403	FlyBaseID:	FBgn0030578	Length:	285	Species:	Drosophila melanogaster
Sequence 2:	NP_001023510.1	Gene:	lep-2 / 176918	WormBaseID:	WBGene00002278	Length:	413	Species:	Caenorhabditis elegans

Alignment Length:	302	Identity:	112/302 - (37%)
Similarity:	155/302 - (51%)	Gaps:	46/302 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RSQTICRFHLLGICRFGDLCRFSHDETTPNDNQSPQISEIADEVVENEQVVASTSSYSRQMTW-- 67
            |::.||.|:|:|.|.:|..|||.|  |.|.:::.|..|  ..:..:|:|.:.::....|....
Worm    31 RNENICHFNLVGKCSYGRACRFLH--TRPRNDELPSCS--TPQTSQNQQNLQNSGQRVRPKQLPE 91

  Fly    68 ----ANAPEFVPRYK-------------ANSAD-------FQATEGVQDI--CPY---GGSC-IW 102
                |.|.|||||:|             |.|||       ||::.....:  |||   .|.| ..
Worm    92 LKFNAQAAEFVPRWKMPQRGPVTSYAGAAASADHGESSSSFQSSHEQAQLMMCPYHQKSGDCNRQ 156

  Fly   103 GSKCSYPLHMEICKMCDLYCLHPMDQNQRRAHNRECLEQHEQAMELSFAIARSKDKMCGICFDTV 167
            ...|.: .|...|.||..:.|||.:...|:.|..||:..|...||.:|.:.:::.|.||||.:.:
Worm   157 DMDCPF-AHGNYCDMCQQWSLHPYNAELRKKHENECVANHTTEMERAFLLQKTEQKTCGICMENI 220

  Fly   168 VEKKGRERRFGILSKCKHIFCLTCIRTWRQAHQFE---ATVT-RGCPECRVFSEFVCPSAYWVDT 228
            .||   ..|||||:.|:|.|||.|||.||...|..   ||.| |.|||||..|::|.||.:||::
Worm   221 FEK---NLRFGILNGCQHCFCLDCIRQWRSKDQENVELATKTVRSCPECRQHSDYVIPSLFWVES 282

  Fly   229 KEEKDKLLSEYRAAMGAKDCKYFNG--GLGKCPFGNKCFYRH 268
            .:|||.|:..|:.....|.|||::.  ..|.|||||||||:|
Worm   283 GQEKDLLIEMYKENTKRKICKYYSNERSRGACPFGNKCFYKH 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5347	NP_572970.1	ZnF_C3H1	4..30	CDD:214632	12/24 (50%)
		PHA03096	<80..239	CDD:222981	68/175 (39%)
		RING	159..213	CDD:238093	29/57 (51%)
lep-2	NP_001023510.1	zf-CCCH_3	1..>56	CDD:406158	12/26 (46%)
		PHA03096	<157..302	CDD:222981	60/148 (41%)
		RING-HC_MKRN	213..267	CDD:319435	29/56 (52%)
		COG5252	<275..>331	CDD:227577	24/50 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159061
Domainoid	1	1.000	62	1.000	Domainoid score	I6838
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32175
Inparanoid	1	1.050	193	1.000	Inparanoid score	I2539
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58455
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		otm14263
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2178
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.040