DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5347 and mkrn1

DIOPT Version :9

Sequence 1:	NP_572970.1	Gene:	CG5347 / 32403	FlyBaseID:	FBgn0030578	Length:	285	Species:	Drosophila melanogaster
Sequence 2:	NP_694510.1	Gene:	mkrn1 / 170782	ZFINID:	ZDB-GENE-020213-1	Length:	439	Species:	Danio rerio

Alignment Length:	329	Identity:	133/329 - (40%)
Similarity:	176/329 - (53%)	Gaps:	50/329 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSYRRSQTICRFHLLGICRFGDLCRFSHDETTPND---NQSPQISEIADEVVENEQVVA-----S 57
            :|..:...||:|...|.|.|||.||:.|.:.:..|   :..|.:...|..:....:.|:     :
Zfish    44 LSSCKQTMICKFFQKGCCAFGDRCRYEHTKPSKQDEVPSSKPSMPLTAAPLAGTPEPVSDGPGGT 108

  Fly    58 TSSY-----SRQMTWANAPEFVP----------------------RYKANSADFQATEGVQDICP 95
            |.:.     |..:.|.||.||||                      .|:...|:   .|..:.:||
Zfish   109 TGAQEKPQGSGAVDWVNAAEFVPGQPYCGRADPVLCEGPGPLIEEEYEKEQAN---KEMKKQLCP 170

  Fly    96 YG--GSCIWGSKCSYPLHMEICKMCDLYCLHPMDQNQRRAHNRECLEQHEQAMELSFAIARSKDK 158
            |.  |.|.:|..|:| ||.::|.||.|..|||.|.:||..|.|.|:|.||:.||:||||.||||.
Zfish   171 YAAVGECRYGLNCAY-LHGDVCDMCGLQVLHPSDTSQRSQHIRACIEAHEKDMEISFAIQRSKDM 234

  Fly   159 MCGICFDTVVEKKG-RERRFGILSKCKHIFCLTCIRTWRQAHQFEATVTRGCPECRVFSEFVCPS 222
            |||:|.:.|.||.. .||||||||.|.|.:||.|||.||.|.|||:.:.:.|||||:.|.||.||
Zfish   235 MCGVCMEVVFEKTNPSERRFGILSNCCHCYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPS 299

  Fly   223 AYWVDTKEEKDKLLSEYRAAMGAKDCKYFNGGLGKCPFGNKCFYRH---HRRCDDNQTQ-----S 279
            .|||:.||||.:|:.:|:..||.|.|:||:.|.|.||||..|||:|   ..|.::.|.|     |
Zfish   300 EYWVEDKEEKQQLIQKYKDGMGTKPCRYFDEGRGTCPFGANCFYKHAFPDGRLEEPQPQRRQNGS 364

  Fly   280 NAVN 283
            |..|
Zfish   365 NGRN 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5347	NP_572970.1	ZnF_C3H1	4..30	CDD:214632	11/25 (44%)
		PHA03096	<80..239	CDD:222981	84/161 (52%)
		RING	159..213	CDD:238093	31/54 (57%)
mkrn1	NP_694510.1	ZnF_C3H1	18..44	CDD:214632	133/329 (40%)
		Torus	<52..84	CDD:292749	12/31 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..118		5/44 (11%)
		PHA03096	<176..325	CDD:222981	82/149 (55%)
		Makorin-type Cys-His. /evidence=ECO:0000255	191..218		14/26 (54%)
		RING	235..290	CDD:238093	31/54 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..371		5/17 (29%)
		MKRN1_C	357..437	CDD:292443	4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32175
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3175
OMA	1	1.010	-	-		QHG58455
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm6616
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2178
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.970