DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15890 and Slc46a3

DIOPT Version :9

Sequence 1:	NP_001285245.1	Gene:	CG15890 / 32401	FlyBaseID:	FBgn0030576	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001343931.1	Gene:	Slc46a3 / 71706	MGIID:	1918956	Length:	460	Species:	Mus musculus

Alignment Length:	472	Identity:	118/472 - (25%)
Similarity:	202/472 - (42%)	Gaps:	104/472 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 AYIMPSVLSNLATQNLNLEKACRVNMAYGDEVCDALTRR---QTANYTLE-----EETVQQMVAR 134
            ::|.|::|.|.....|.:....:.           :.||   :|.|||..     .|..|...:.
Mouse     4 SFIEPAILLNAFAMTLTIPLTAQY-----------VYRRIWEETGNYTFASNSNGSECDQNKSSS 57

  Fly   135 MAAWKTVIQ-------------SLFPCLLILFW-GSWSDRHRRRKPCILIPVVGEFLGVVG--LM 183
            :.|::..:|             :|.|.|:..|. .:.||.|.|:.|.:|     ..||.:|  ..
Mouse    58 IFAFREEVQKKASLFNLQVEMSALIPGLVSTFMLLASSDNHGRKLPMVL-----SSLGSLGTNTW 117

  Fly   184 LCV--YFEQAPME---AAALTEAIFPSLSGGWFTMLMGVFSYIADITTE-EDRTLRIGILNVCFS 242
            ||:  ||: .|::   |:....|:|    |.:.|.....|:||.|...| :.|.:||.||:  |.
Mouse   118 LCMMSYFD-LPLQLLIASTFIGALF----GNYTTFWGACFAYIVDQQKEYKHRIIRIAILD--FM 175

  Fly   243 VGVPIGMA--FSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSAEQKSL-----L 300
            :||..|:.  .||..::::||...:.|:|...::...|..|||.:|..  |.|::..::     |
Mouse   176 LGVVTGLTGLSSGYFIRELGFVWSYFITAMVLIVNLAYILFFLNDPIK--ESSSQIVTMSCIESL 238

  Fly   301 ADFFDKEHVVQTFRVAFKKGENQRRKRVIL----LMIVVMVIIGPLHGEMAVTYLFTRFRFN--- 358
            .|.|.:.:::      ||.|.::|:..:.|    |:|...||||       ::.:||.:...
Mouse   239 KDLFYRTYML------FKNGSSKRQALLCLLIFTLVIYFFVIIG-------ISPIFTLYELGPPL 290

  Fly   359 -WSEV---------EFSFFSTYAMFTGLIGVIFCVGILSHKLNIDDALVGVLSSTSKILSSFVYA 413
             |:||         ..||.|:   |.|:....:|:      .:|..|.:|:.::   ::...:.|
Mouse   291 CWNEVYIGYGSALGSVSFLSS---FLGIWLFSYCL------KDIHIAYIGIFTT---MVGMTLAA 343

  Fly   414 FATLPWHMYLGGLVEIFNGTAFIAMRSIATKLVSKDELGKVNSLFGVAEALMPMVFAPMYTTLYA 478
            |......|:|..:..||.......:||:.:|:|...|.|.:.:.....|.|..:.....|:.:|:
Mouse   344 FTRTTLMMFLVRIPFIFTIMPLSVLRSMLSKVVHSTEQGALFACIAFLETLAGVTSTSAYSGIYS 408

  Fly   479 ATLRVLPGAFFLLGGGL 495
            ||:...||..|||..||
Mouse   409 ATVAWYPGFIFLLSAGL 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15890	NP_001285245.1	MFS	135..507	CDD:119392	105/407 (26%)
CG15890	NP_001285245.1	MFS_1	135..470	CDD:284993	94/380 (25%)
Slc46a3	NP_001343931.1	MFS	3..437	CDD:391944	118/472 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9497
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41733
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8701
orthoMCL	1	0.900	-	-		OOG6_100739
Panther	1	1.100	-	-	LDO	PTHR23507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5729
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.860