DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15890 and Slc46a1

DIOPT Version :9

Sequence 1:	NP_001285245.1	Gene:	CG15890 / 32401	FlyBaseID:	FBgn0030576	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_081016.2	Gene:	Slc46a1 / 52466	MGIID:	1098733	Length:	459	Species:	Mus musculus

Alignment Length:	466	Identity:	107/466 - (22%)
Similarity:	185/466 - (39%)	Gaps:	71/466 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 NPPVK-RSWREKIRLVANNVTV--EPILAAYIMPSVLSNLATQNLNLEKACRVNMAYGDEVCDAL 113
            |.||. |...|.:..:||...|  .|:...|:.....:.|........:.|      |::..|.|
Mouse    16 NAPVLFRGPVEPLVFLANFALVLQGPLTTQYLWHRFSTELGYNGTRHRENC------GNQSADPL 74

  Fly   114 TRRQTANYTLEEETVQQMVARMAAWKTVIQSLFPCLLILFW----GSWSDRHRRRKPCILIPVVG 174
            .:        |.||:      .:.| |:..::...|:.|||    |:||||..|| |.:::..:|
Mouse    75 MK--------EVETL------TSHW-TLYMNVGGFLVGLFWSTLLGAWSDRVGRR-PLLVLASLG 123

  Fly   175 EFLGVVGLMLCVYFEQAPMEAA--ALTEAIFPSLSGGWFTMLMGVFSYIADITTEEDRTLRIGIL 237
            ..|..|   :.::..|..:...  .|..|:. :|.|.:..:|...|:.:||:::...||.|:.:|
Mouse   124 LLLQAV---VSIFVVQLELHVGFFVLGRALC-ALLGDFNGLLAASFASVADVSSNHSRTFRMALL 184

  Fly   238 NVCFSVGVPIGMAFSGVLLKQIGFYGVFSISAAFYVIAFVYGFFFLEEPQSRPEKSAEQKSLLAD 302
            ..|..|...:.....|..|:..|:...|.::.|..::..:|..|...|....|:.:.
Mouse   185 EACIGVAGTLASLLGGHWLRAQGYANPFWLALALLIVMALYAAFCFGETVKEPKSTR-------- 241

  Fly   303 FFDKEHVVQTFRVAFKKGENQRRKRVILLMIVVMVIIGPLHGEMAVTYLF-TRFRFNWSEVEFSF 366
            .|...|.....|:.......:.|..:.|..:.:.|::....|...:..|: ......|......:
Mouse   242 LFTLRHHRSIARLYVVPAPEKSRMHLALYSLAIFVVVTVHFGAQDILTLYELSAPLCWDSKLIGY 306

  Fly   367 FST---YAMFTGLIG---VIFCVGILSHKLNIDDALVGVLSSTSKILSSFVYAFATLPWHMYLGG 425
            .|.   ....|.|:|   :.||:.         |..|..:.....||...|:||||:...|:.|
Mouse   307 GSAAQHLPYLTSLLGLRLLQFCLA---------DTWVAEIGLAFNILGMVVFAFATITPLMFTG- 361

  Fly   426 LVEIFNGTAFIAM------RSIATKLVSKDELGKVNSLFGVAEALMPMVFAPMYTTLYAATLRVL 484
                 .|..|:::      |:..:||||:.|.|.:.|......:|..::.:.::.::|.|||..:
Mouse   362 -----YGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSIYPATLNFM 421

  Fly   485 PGAFFLLGGGL 495
            .|..||||.||
Mouse   422 KGFPFLLGAGL 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15890	NP_001285245.1	MFS	135..507	CDD:119392	89/380 (23%)
CG15890	NP_001285245.1	MFS_1	135..470	CDD:284993	78/353 (22%)
Slc46a1	NP_081016.2	MFS	73..443	CDD:119392	93/403 (23%)
Slc46a1	NP_081016.2	MFS_1	94..407	CDD:284993	76/340 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9497
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8701
orthoMCL	1	0.900	-	-		OOG6_100739
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5729
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.860