DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15890 and slc46a1

DIOPT Version :9

Sequence 1:	NP_001285245.1	Gene:	CG15890 / 32401	FlyBaseID:	FBgn0030576	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_956579.1	Gene:	slc46a1 / 393255	ZFINID:	ZDB-GENE-040426-1012	Length:	481	Species:	Danio rerio

Alignment Length:	507	Identity:	117/507 - (23%)
Similarity:	199/507 - (39%)	Gaps:	103/507 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KYTVNHEPPPPSAMTTTQSTNSGVDKPIAKEKDNGTTNPPVKRSWREKIRLVANNVTVEPILAAY 79
            :.|.|..|||.|.             |:                          :|||||::...
Zfish    27 RVTENKAPPPCSC-------------PL--------------------------SVTVEPVMFLS 52

  Fly    80 IMPSVL-SNLATQNL--NLEKACRVNMAYGDEV--CDALTRRQTANYTLEEETVQQMVARMAAWK 139
            ....|| :.|.||.|  .|.:....|   |.:.  |:|    .|.:..|:.| |:.:.|..:.:.
Zfish    53 TFSIVLQAPLCTQYLWDRLSEDVGYN---GTKTGGCNA----STVHDPLQTE-VETLTAHWSLYI 109

  Fly   140 TVIQSLFPCLLILFWGSWSDRHRRRKPCILIPVVG------EFLGVVGLMLCVYFEQAPMEAAAL 198
            .:...|....:::..||||||..||. .::||.:|      .:|.|:.|.|.|::        .|
Zfish   110 NLGGFLVGLFMVILLGSWSDRAGRRL-VLIIPSLGLAVQAAVYLTVMYLKLPVFW--------FL 165

  Fly   199 TEAIFPSLSGGWFTMLMGVFSYIADITTEEDRTLRIGILNVCFSVGVPIGMAFSGVLLKQIGFYG 263
            ...|...|||.:..:|.|.|:|:||.:....||.|:.||..|..:.........|...:..|:..
Zfish   166 IGRICSGLSGDFNAILAGCFAYVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYIN 230

  Fly   264 VFSISAAFYVIAFVYGFFFLEE-----PQSRPEKSAEQKSLLADFFDKEHVVQTFRVAFKKGENQ 323
            .|.:..|..:.|.:|.:.|:.|     ||:|             .|...|.....|:........
Zfish   231 PFWLVLATNLTAALYAYLFVPETVTPDPQAR-------------LFSTRHHQAVCRLYSSDAPPG 282

  Fly   324 RRKRVILLMIVVMVIIGPLHGEMAVTYLFTRFRFN----WSEVEFSFFST---YAMFTGLIGVIF 381
            ||.::.|.::...::: .:|  :..:.|:..:..:    |......:.|.   .|..|.|
Zfish   283 RRSKLWLYILCFFLVV-TVH--LGCSDLYVLYELSAPLCWGPELIGYGSAAKHLAYLTSL----- 339

  Fly   382 CVGILSHKLNIDDALVGVLSSTSKILSSFVYAFATLPWHMYLG-GLVEIFNGTAFIAMRSIATKL 445
             .|:.:.:..::|:.|.::..||.::...|.:.|.....|:.| ||..:|..:..: :||..:||
Zfish   340 -TGLRAMQCCLEDSWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMASTPV-LRSKLSKL 402

  Fly   446 VSKDELGKVNSLFGVAEALMPMVFAPMYTTLYAATLRVLPGAFFLLGGGLTL 497
            |...|.|.:.:.....|.|..:|.:.::..||.|||..:.|..|:.|..:.|
Zfish   403 VDPAEQGALFASVACVEGLCSLVSSGVFNALYPATLHFMKGFPFVFGAAILL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15890	NP_001285245.1	MFS	135..507	CDD:119392	89/382 (23%)
CG15890	NP_001285245.1	MFS_1	135..470	CDD:284993	80/353 (23%)
slc46a1	NP_956579.1	MFS	93..460	CDD:119392	93/395 (24%)
slc46a1	NP_956579.1	MFS_1	114..427	CDD:284993	80/344 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7409
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6480
orthoMCL	1	0.900	-	-		OOG6_100739
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5729
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.860