Protein Alignment NetB and NTN1

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_004813.2
• Gene: NTN1 / 9423
• HGNCID: 8029
• Length: 604
• Species: Homo sapiens
• Alignment Length: 815
• Identity: 333/815 - (40%)
• Similarity: 426/815 - (52%)
• Gaps: 241/815 - (29%)

  Fly     1 MVRATGTRMGLLLPIILALAIGSSAAGIS-------SNDPCYFE-GKPRKCLPSFVNAAYGNPVQ 57
            |:||....:..|..:...:.......|:|       ..|||..| |.||:|:|.|||||:|..|:
Human     1 MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVR 65

  Fly    58 ASSVCGAQQPERYCELLRDGNAGECRSCE-------QQRYGPAALTDLNNPSNVTCWRS-GAVNV 114
            .||.|| :.|.|||.:...|.. ..|||.       ::.:.||.|||||||.|:|||:| ..:..
Human    66 VSSTCG-RPPARYCVVSERGEE-RLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQF 128

  Fly   115 PHDPDSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQK 179
            ||        |||||||||||:|:||:||.||  ||||:|:||:||.|:|:||.||||||:||:|
Human   129 PH--------NVTLTLSLGKKFEVTYVSLQFC--SPRPESMAIYKSMDYGRTWVPFQFYSTQCRK 183

  Fly   180 FYGRPDRAKISKFNEQEARCINSQHD----TGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTAT 240
            .|.||.||.|:|.|||||.|.:|..|    :||.   .||:||:|||||:|.|:|.|||||||||
Human   184 MYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGL---IAFSTLDGRPSAHDFDNSPVLQDWVTAT 245

  Fly   241 DIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGY 305
            ||||.|.||            :.|.||        .:||::|..|
Human   246 DIRVAFSRL------------HTFGDE--------NEDDSELARD-------------------- 270

  Fly   306 DEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGK 370
                                                                             
Human   271 ----------------------------------------------------------------- 270

  Fly   371 VTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDE 435
                                |..|||||..|||||||||||:.||           .|:||
Human   271 --------------------SYFYAVSDLQVGGRCKCNGHAARCV-----------RDRDD---- 300

  Fly   436 DTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQC 500
                                  ::.|.|:||||||||:|||||::||||.|||..:||||..|.|
Human   301 ----------------------SLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNC 343

  Fly   501 NGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHP 565
            |.||||||||:||||||||.|||||.||:|:|.||:||||:||||||..||..|||.||.|||||
Human   344 NLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHP 408

  Fly   566 VGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGG 630
            ||:.|||||..:||||||:||||:||||||:||||:||.:|||||:|.......|
Human   409 VGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAA---------- 463

  Fly   631 TGDYKDGGGSQVEEMKKYCGKCKASPKKL--NLNKFCMEDYAILAKVIGHDRASQDISTEKFSIE 693
                     |.|||.:.....||||..||  |:.|:|.:|||:...::..|:|
Human   464 ---------SSVEEPEDCDSYCKASKGKLKINMKKYCKKDYAVQIHILKADKA------------ 507

  Fly   694 RQNEIYKYEINIQTIFKRNPMSGTTSSLLGRGNMMLLVPRKSIECQCPKIKLNKSYLILG--RDS 756
              .:.:|:.:||.:::|:    ||  |.:.||:..|.:..:.|.|:|||||..|.||:||  .||
Human   508 --GDWWKFTVNIISVYKQ----GT--SRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDS 564

  Fly   757 EAAPGYLAIGPSSVVLEWKDEWSLRMKRFQRRARK 791
            ....|.:| ..||:|::|:|.|:.|:::||:|.:|
Human   565 PDQSGIVA-DKSSLVIQWRDTWARRLRKFQQREKK 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	126/236 (53%)
		EGF_Lam	<458..484	CDD:238012	17/25 (68%)
		EGF_Lam	498..555	CDD:238012	42/56 (75%)
		EGF_Lam	560..608	CDD:238012	35/47 (74%)
		NTR_netrin-1_like	661..791	CDD:239634	43/131 (33%)
NTN1	NP_004813.2	LamNT	46..283	CDD:214532	139/376 (37%)
		EGF_Lam	284..329	CDD:238012	32/81 (40%)
		Laminin_EGF	341..401	CDD:395007	45/59 (76%)
		Laminin_EGF	404..>441	CDD:395007	28/36 (78%)
		NTR_netrin-1_like	487..601	CDD:239634	44/133 (33%)
		Cell attachment site. /evidence=ECO:0000255	530..532		1/1 (100%)