DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and NTNG2

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_011517396.1	Gene:	NTNG2 / 84628	HGNCID:	14288	Length:	636	Species:	Homo sapiens

Alignment Length:	699	Identity:	131/699 - (18%)
Similarity:	202/699 - (28%)	Gaps:	338/699 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AGISSNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNAGECRSCEQQRY 90
            :||:..||     ..|.|       ::.||...|:.|.|..|:                   ..:
Human    57 SGITCGDP-----PERFC-------SHENPYLCSNECDASNPD-------------------LAH 90

  Fly    91 GPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELT-YISLSFCPRSPRPDS 154
            .|..:.|.......|.|:|  :.....|.   |....:|||..|..||| .:.::|  ...||..
Human    91 PPRLMFDKEEEGLATYWQS--ITWSRYPS---PLEANITLSWNKTVELTDDVVMTF--EYGRPTV 148

  Fly   155 LAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHDTGGAAQRFAFNTLE 219
            :.:.||.|.|:||||:|||:..|.:.:|.                         :|:|
Human   149 MVLEKSLDNGRTWQPYQFYAEDCMEAFGM-------------------------SARR------- 181

  Fly   220 GRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLEL 284
                |.|:.||..              ||         |.....:|...|..:|:
Human   182 ----ARDMSSSSA--------------HR---------VLCTEEYSRWAGSKKEK---------- 209

  Fly   285 DGEQDEYDYNLQDNDSADAG---------YDEYEEP---KKHLELDDDHLHLDYASDGESVVKRQ 337
                 ...:.::|..:..||         |...|..   |:...|.|..:.|...:.|.:.|:|:
Human   210 -----HVRFEVRDRFAIFAGPDLRNMDNLYTRLESAKGLKEFFTLTDLRMRLLRPALGGTYVQRE 269

  Fly   338 GKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVG 402
            ..:|                                                  ..||:|:..|.
Human   270 NLYK--------------------------------------------------YFYAISNIEVI 284

  Fly   403 GRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNT 467
            ||||||.||:.|  ::..||                                    :.|.|:|||
Human   285 GRCKCNLHANLC--SMREGS------------------------------------LQCECEHNT 311

  Fly   468 AGPECERCKPFYFDRPWGRAT--------------------------DND--------------- 491
            .||:|.:||..:..|.|...:                          |.|
Human   312 TGPDCGKCKKNFRTRSWRAGSYLPLPHGSPNACATAGSFGSISRSQKDPDPKGPVATAATTAMTG 376

  Fly   492 ----------------------------------------------------------------- 491

Human   377 APTTPVPSTSTAWAPMAPSTPQPTEWTRPSTAAPLSSRWSQVASRAEAVGTPAAAPAPAKGYKLF 441

  Fly   492 -----------ANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYY 545
                       ..|.:.|:|.||:.||.: ::...:.      .|.:|:|:|.|::|.:||.|||
Human   442 QLKPKSPQVMPIEEFQDCECYGHSNRCSY-IDFLNVV------TCVSCKHNTRGQHCQHCRLGYY 499

  Fly   546 RDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRC 594
            |:.:...:...||..|:|:.:||....||. :|.|.|:||..|..|:.|
Human   500 RNGSAELDDENVCIECNCNQIGSVHDRCNE-TGFCECREGAAGPKCDDC 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	47/224 (21%)
		EGF_Lam	<458..484	CDD:238012	11/25 (44%)
		EGF_Lam	498..555	CDD:238012	18/56 (32%)
		EGF_Lam	560..608	CDD:238012	14/35 (40%)
		NTR_netrin-1_like	661..791	CDD:239634
NTNG2	XP_011517396.1	Laminin_N	60..285	CDD:278484	69/386 (18%)
		EGF_Lam	286..332	CDD:238012	22/83 (27%)
		EGF_Lam	459..507	CDD:238012	18/54 (33%)
		Laminin_EGF	515..562	CDD:278482	14/34 (41%)
		EGF_2	562..592	CDD:285248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810