DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetB and USHBP1

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001308346.1	Gene:	USHBP1 / 83878	HGNCID:	24058	Length:	703	Species:	Homo sapiens

Alignment Length:	124	Identity:	28/124 - (22%)
Similarity:	44/124 - (35%)	Gaps:	38/124 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 ATTPPQQPPKVTPPGKVTP----------------PSTAAPSAAASAVTL-PISQHYAVSDFAVG 402
            ||.|..:..:..|||::.|                ||.|.|..::....| |:.:   ||...:|
Human     5 ATRPRSRRGRHAPPGELDPVAESSEEVEAASGSSKPSFAPPPVSSGLEQLGPMEE---VSGQGLG 66

  Fly   403 GRC--KCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTM 459
            .|.  |.:|           |||..|:..     .:.|..|::..|......:..|.|:
Human    67 SRTDKKMDG-----------GSGRELASA-----PEVPHKPAVEAHQAPEAALQYKETV 109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532
		EGF_Lam	<458..484	CDD:238012	1/2 (50%)
		EGF_Lam	498..555	CDD:238012
		EGF_Lam	560..608	CDD:238012
		NTR_netrin-1_like	661..791	CDD:239634
USHBP1	NP_001308346.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113		28/124 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..256
		MCC-bdg_PDZ	299..363	CDD:287477
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..416
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..583
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900