Protein Alignment NetB and ntn1

DIOPT Version :9

• Sequence 1: NP_001162753.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_001072385.1
• Gene: ntn1 / 779839
• XenbaseID: XB-GENE-989335
• Length: 601
• Species: Xenopus tropicalis
• Alignment Length: 805
• Identity: 277/805 - (34%)
• Similarity: 382/805 - (47%)
• Gaps: 241/805 - (29%)

  Fly     9 MGLLLPIILALAIGSSAA---GISSNDPCY-FEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPER 69
            :.||.|:.......|:.|   |.:.:.||| .:.:|:.|:|.|:|.|.|..|..|:.|| :.|::
 Frog    14 ISLLCPVPRGQENNSNKASTHGGTPDGPCYDAKQRPKYCIPDFINVALGQEVITSNTCG-RTPQK 77

  Fly    70 YCELLRDGN--AGECRSCEQQR----YGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTL 128
            .|..|...|  :..|:.|:|:|    |.|:.:||.:..   |||:|       :.....|.||||
 Frog    78 LCYFLDSTNVTSRRCQLCDQKRPENSYPPSYMTDTDAQ---TCWKS-------ESGITFPQNVTL 132

  Fly   129 TLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFN 193
            ||.||:::||.|.||.||  ||||||:||:||.|:|:||.||||||:.|::.|.:...:.|||..
 Frog   133 TLPLGRRFELVYASLRFC--SPRPDSMAIYKSMDYGKTWIPFQFYSTHCRRVYDQATTSAISKPM 195

  Fly   194 EQEARCINSQHD----TGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQ 254
            :.||.|.:.|..    |.|..   ||..|.|||||...:.|.|||||||||||||||:||.
 Frog   196 QHEATCTDFQTGVKPLTKGLV---AFMPLAGRPSARRFEYSPVLQDWVTATDIRVVFNRLH---- 253

  Fly   255 LLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDD 319
                                                                             
 Frog   254 ----------------------------------------------------------------- 253

  Fly   320 DHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAAS 384
               |          .|:.|..:.:|:
 Frog   254 ---H----------GKKMGIRRKTAF--------------------------------------- 266

  Fly   385 AVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGR 449
                     |.||:..||||||||||||.|.|
 Frog   267 ---------YGVSEIQVGGRCKCNGHASRCTA--------------------------------- 289

  Fly   450 STQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELY 514
                 .|..:.|.|:|||.||||:.|||||:||||.|||.::|:||..|:||.|:.|||||:|||
 Frog   290 -----GKEGLMCECQHNTIGPECDACKPFYYDRPWQRATPSNAHECVACECNLHSHRCRFNMELY 349

  Fly   515 KLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQ 579
            |||||.|||||.||:|:|.||:||||::||.||.:||...||.||.|.|||:|:....||..:||
 Frog   350 KLSGRKSGGVCLNCRHNTAGRHCHYCKQGYKRDLSKPITSRKACKPCQCHPIGAVNAMCNQTTGQ 414

  Fly   580 CPCKEGVTGLTCNRCARGYQQTRSHVAPCIKV----PTNANMIQAESAGGGGGGGTGDYKDGGGS 640
            |.||.||||.||||||.||||:||...||:::    .|.|:..|...||..|
 Frog   415 CQCKTGVTGPTCNRCAPGYQQSRSAHMPCVRIQEEMTTTASYPQEWKAGTNG------------- 466

  Fly   641 QVEEMKKYCGKCKASPKKLNLNKFCMEDYAILAKVIGHDRASQDISTEKFSIERQNEIYKYEINI 705
              .|.:.|| |...|...:||.|:|.:||.:.|:::              |:|:..|.:::...:
 Frog   467 --TECQSYC-KPSHSRVHMNLRKYCKKDYVLRAQLL--------------SMEKSGEWWQFTATV 514

  Fly   706 QTIFKRNPMSGTTSSLLGRGNMMLLVPRKSIECQCPKIKLNKSYLILGRDSEAA-PGYLAIGPSS 769
            .|::::..:.      :.||:..|.||...:.|.|.::::.|||||:|.|.|:. |..|.:..:|
 Frog   515 LTVYRQRRVP------IRRGDQPLWVPDHDLACDCLRVQVGKSYLIIGNDEESPDPARLILDKNS 573

  Fly   770 VVLEWKDEWSLRMKRFQRRAR--KC 792
            :.|.|:|.|..:::|||::.|  ||
 Frog   574 LALPWRDVWGHKLRRFQQQERRGKC 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	100/233 (43%)
		EGF_Lam	<458..484	CDD:238012	16/25 (64%)
		EGF_Lam	498..555	CDD:238012	38/56 (68%)
		EGF_Lam	560..608	CDD:238012	28/47 (60%)
		NTR_netrin-1_like	661..791	CDD:239634	36/132 (27%)
ntn1	NP_001072385.1	Laminin_N	61..276	CDD:365840	102/360 (28%)
		EGF_Lam	277..321	CDD:238012	30/81 (37%)
		EGF_CA	333..386	CDD:389777	36/52 (69%)
		EGF_Lam	395..444	CDD:238012	29/48 (60%)
		NTR_netrin-1_like	484..598	CDD:239634	36/133 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	105	1.000	Domainoid score	I6558
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	619	1.000	Inparanoid score	I870
OMA	1	1.010	-	-		QHG48023
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.080