DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and ntn2

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001032492.1	Gene:	ntn2 / 641469	ZFINID:	ZDB-GENE-050310-2	Length:	600	Species:	Danio rerio

Alignment Length:	791	Identity:	312/791 - (39%)
Similarity:	412/791 - (52%)	Gaps:	229/791 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SAAGISSNDPCYFE-GKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNAGECRSC-- 85
            |...::..||||.| |..|:|:|.|:|||:|..|..||||| :...|.|.|:...:....|:|
Zfish    16 SGPQVTPTDPCYEETGAARRCIPEFINAAFGQEVSVSSVCG-RPVSRSCSLVERDDRPAVRTCQI 79

  Fly    86 ----EQQRYGPAA-LTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYISLSF 145
                :.:...||: |||||:..|:|||:|..:       .:.|.|||||||||||:|:||:||.|
Zfish    80 CDASDPRNAHPASYLTDLNSAHNLTCWQSENL-------QSSPLNVTLTLSLGKKFEITYVSLQF 137

  Fly   146 CPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHD----T 206
            |  ||||:||||:||.|:|:||.|:|||||||::.|.||::|.|:|.|||||.|.:...|    :
Zfish   138 C--SPRPESLAIYKSMDYGRTWTPYQFYSSQCRRMYNRPNKAAITKQNEQEALCTDGHTDLYPLS 200

  Fly   207 GGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGS 271
            ||.   .||:||:||||..|.|||.|||||||.|||||||.|    ||..:.
Zfish   201 GGL---IAFSTLDGRPSGKDFDSSPVLQDWVTVTDIRVVFSR----PQHTRA------------- 245

  Fly   272 REEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKR 336
                      |.:.|.:.|        |:..|
Zfish   246 ----------LPMSGRESE--------DALGA--------------------------------- 259

  Fly   337 QGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAV 401
                                           ||                 :|| :.:|||.||.|
Zfish   260 -------------------------------PG-----------------SLP-TYYYAVGDFQV 275

  Fly   402 GGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHN 466
            |||||||||||.||.            :.||:                         :.|.||||
Zfish   276 GGRCKCNGHASRCVR------------EKDGK-------------------------LLCECKHN 303

  Fly   467 TAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHD 531
            |.||||:|||||::||||.|||..:||||..|.||.||||||||:||||||||.|||||.||:|:
Zfish   304 TEGPECDRCKPFHYDRPWQRATGKEANECLPCNCNLHARRCRFNMELYKLSGRKSGGVCMNCRHN 368

  Fly   532 TTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCAR 596
            |.||:||||:||:|||..|...||:.||.|||||||:.|||||..:||||||:||||:||||||:
Zfish   369 TAGRHCHYCKEGFYRDMGKAITHRRACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAK 433

  Fly   597 GYQQTRSHVAPCIKVPT---NANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASPKK 658
            ||||:||.||||||:|.   .|.:...|                   :..:...||...|.: .|
Zfish   434 GYQQSRSPVAPCIKIPVIKPTAVISTTE-------------------EPADCDSYCKPLKGN-LK 478

  Fly   659 LNLNKFCMEDYAILAKVIGHDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSLLG 723
            :|:.|:|.:|||:...|:              .:|...:..|:.:::.:::|      :....|.
Zfish   479 INMKKYCKKDYAVQVSVL--------------DMETVGDWAKFSVSLMSVYK------SRGDPLK 523

  Fly   724 RGNMMLLVPRKSIECQCPKIKLNKSYLILGRDSEAA----PGYLAIGPSSVVLEWKDEWSLRMKR 784
            ||:.||.|..|.:.|:||:|.:.|.:||||.....|    || |....:|:|::|:|.|:.|:::
Zfish   524 RGDHMLWVHMKDLACKCPRIHMGKRFLILGSTEGTANPERPG-LQADKNSLVIQWRDIWTRRLRK 587

  Fly   785 FQRRAR--KCS 793
            |||:.:  |||
Zfish   588 FQRKEKKGKCS 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	118/235 (50%)
		EGF_Lam	<458..484	CDD:238012	17/25 (68%)
		EGF_Lam	498..555	CDD:238012	40/56 (71%)
		EGF_Lam	560..608	CDD:238012	36/47 (77%)
		NTR_netrin-1_like	661..791	CDD:239634	38/135 (28%)
ntn2	NP_001032492.1	Laminin_N	45..277	CDD:278484	124/361 (34%)
		EGF_Lam	278..323	CDD:238012	32/81 (40%)
		EGF_Lam	334..384	CDD:238012	37/49 (76%)
		EGF_Lam	397..445	CDD:238012	36/47 (77%)
		NTR_netrin-1_like	481..597	CDD:239634	38/136 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580917
Domainoid	1	1.000	101	1.000	Domainoid score	I6881
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	631	1.000	Inparanoid score	I821
OMA	1	1.010	-	-		QHG48023
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	1	1.000	-	-		FOG0003523
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104609
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.870