DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and Ntn4

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_067295.2	Gene:	Ntn4 / 57764	MGIID:	1888978	Length:	628	Species:	Mus musculus

Alignment Length:	828	Identity:	201/828 - (24%)
Similarity:	313/828 - (37%)	Gaps:	251/828 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MGLLLPIILALAIGSSAAGIS----SNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPER 69
            ||....::|.....:.|||::    :|..|     .:.|.|...|.|.|..::|.::||....|.
Mouse     1 MGSCARLLLLWGCSAVAAGLNGVAGANSRC-----EKACNPRMGNLALGRKLRADTMCGQNATEL 60

  Fly    70 YCELLRDGNAG------ECRSCEQQR----YGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPD 124
            :|  ....||.      :|..|....    :.|:|:.|.:.....|.|:| |.:|..:
Mouse    61 FC--FYSENADLTCRQPKCDKCNAAHSHLAHPPSAMADSSFRFPRTWWQS-AEDVHRE------- 115

  Fly   125 NVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKI 189
              .:.|.|..::..|::.:.|  :||||.::.:.:|.|||:||:|::::::.|...:|..|.. :
Mouse   116 --KIQLDLEAEFYFTHLIMVF--KSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDV-V 175

  Fly   190 SKFNEQEARCINSQHDTGGAAQRFAFNTLEGRPSANDLDS--SLVLQDWVTATDIRV-VFHRLEL 251
            .|.....:|..|....|||   ...|..|.   ...|:::  |..:|:.:..|::|| :..|...
Mouse   176 KKGAICTSRYSNPFPCTGG---EVIFRALS---PPYDIENPYSAKVQEQLKITNLRVRLLKRQSC 234

  Fly   252 PPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLE 316
            |.|   :.:.||                                                |.|
Mouse   235 PCQ---INDLNA------------------------------------------------KPH-- 246

  Fly   317 LDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSA 381
                                           |:
Mouse   247 -------------------------------HF-------------------------------- 248

  Fly   382 AASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANH 446
                      .||||.||.|.|.|.|||||.:|:..            :..:....|.|..:.:
Mouse   249 ----------MHYAVYDFIVKGSCFCNGHADQCLPV------------EGFRPIKAPGAFHVVH- 290

  Fly   447 FGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDA--NECKMCQCNGHARRCRF 509
             ||           |.|||||||..|:.|.|.|.||||..|.....  |||:.|:|||||..|.|
Mouse   291 -GR-----------CMCKHNTAGSHCQHCAPLYNDRPWEAADGRTGAPNECRTCKCNGHADTCHF 343

  Fly   510 NLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVG------S 568
            ::.:::.||..|||||.||||:|.|::|..|:.|:|||..:|.:....||.|.|||||      |
Mouse   344 DVNVWEASGNRSGGVCNNCQHNTEGQHCQRCKPGFYRDLRRPFSAPDACKACSCHPVGSAILPFS 408

  Fly   569 TGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSH-VAPC-----------IKVPTNANM---- 617
            :...|:..:|.||||.||.|..|:||..||.....: ..||           ..:.:||::
Mouse   409 SVTFCDPSNGDCPCKPGVAGPHCDRCMVGYWGFGDYGCRPCDCAGSCDPLTGDCISSNADVDWYH 473

  Fly   618 -IQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASPKKL-NLNKFCMEDYAILAKV---IG 677
             :.|..:.......:.:::|..|...   .::.|||:...:.| |...||...|:.:.|:   ..
Mouse   474 EVPAFHSMHNKSEPSWEWEDEQGFSA---LRHSGKCECKEQVLGNPKAFCGMKYSYVLKIKILSA 535

  Fly   678 HDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSLLGRGNMMLLVPRK--SIECQC 740
            ||:.|.                 .|:|::.   :..:..|...:| ||. ..|.|..  :..|.|
Mouse   536 HDKGSH-----------------AEVNVKI---KKVLKSTKLKIL-RGK-RTLYPESWTNRGCTC 578

  Fly   741 PKIKLNKSYLILGRDSEAAPGYLAIGPSSVVLEWKDEWSLRMKRFQRR 788
            |.:.....||:.|.: :...|.|.:...|.|..||.....|:....:|
Mouse   579 PILNPGLEYLVAGHE-DVRTGKLIVNMKSFVQHWKPALGRRVMHILKR 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	57/236 (24%)
		EGF_Lam	<458..484	CDD:238012	14/25 (56%)
		EGF_Lam	498..555	CDD:238012	28/56 (50%)
		EGF_Lam	560..608	CDD:238012	21/54 (39%)
		NTR_netrin-1_like	661..791	CDD:239634	29/133 (22%)
Ntn4	NP_067295.2	Laminin_N	43..260	CDD:278484	65/363 (18%)
		EGF_Lam	261..320	CDD:238012	27/83 (33%)
		Laminin_EGF	332..392	CDD:278482	28/59 (47%)
		Laminin_EGF	395..449	CDD:278482	21/53 (40%)
		NTR_netrin-4_like	517..626	CDD:239633	29/132 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910