Protein Alignment NetB and Ntn4

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_067295.2
• Gene: Ntn4 / 57764
• MGIID: 1888978
• Length: 628
• Species: Mus musculus
• Alignment Length: 828
• Identity: 201/828 - (24%)
• Similarity: 313/828 - (37%)
• Gaps: 251/828 - (30%)

  Fly     9 MGLLLPIILALAIGSSAAGIS----SNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPER 69
            ||....::|.....:.|||::    :|..|     .:.|.|...|.|.|..::|.::||....|.
Mouse     1 MGSCARLLLLWGCSAVAAGLNGVAGANSRC-----EKACNPRMGNLALGRKLRADTMCGQNATEL 60

  Fly    70 YCELLRDGNAG------ECRSCEQQR----YGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPD 124
            :|  ....||.      :|..|....    :.|:|:.|.:.....|.|:| |.:|..:
Mouse    61 FC--FYSENADLTCRQPKCDKCNAAHSHLAHPPSAMADSSFRFPRTWWQS-AEDVHRE------- 115

  Fly   125 NVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKI 189
              .:.|.|..::..|::.:.|  :||||.::.:.:|.|||:||:|::::::.|...:|..|.. :
Mouse   116 --KIQLDLEAEFYFTHLIMVF--KSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDV-V 175

  Fly   190 SKFNEQEARCINSQHDTGGAAQRFAFNTLEGRPSANDLDS--SLVLQDWVTATDIRV-VFHRLEL 251
            .|.....:|..|....|||   ...|..|.   ...|:::  |..:|:.:..|::|| :..|...
Mouse   176 KKGAICTSRYSNPFPCTGG---EVIFRALS---PPYDIENPYSAKVQEQLKITNLRVRLLKRQSC 234

  Fly   252 PPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLE 316
            |.|   :.:.||                                                |.|
Mouse   235 PCQ---INDLNA------------------------------------------------KPH-- 246

  Fly   317 LDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSA 381
                                           |:
Mouse   247 -------------------------------HF-------------------------------- 248

  Fly   382 AASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANH 446
                      .||||.||.|.|.|.|||||.:|:..            :..:....|.|..:.:
Mouse   249 ----------MHYAVYDFIVKGSCFCNGHADQCLPV------------EGFRPIKAPGAFHVVH- 290

  Fly   447 FGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDA--NECKMCQCNGHARRCRF 509
             ||           |.|||||||..|:.|.|.|.||||..|.....  |||:.|:|||||..|.|
Mouse   291 -GR-----------CMCKHNTAGSHCQHCAPLYNDRPWEAADGRTGAPNECRTCKCNGHADTCHF 343

  Fly   510 NLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVG------S 568
            ::.:::.||..|||||.||||:|.|::|..|:.|:|||..:|.:....||.|.|||||      |
Mouse   344 DVNVWEASGNRSGGVCNNCQHNTEGQHCQRCKPGFYRDLRRPFSAPDACKACSCHPVGSAILPFS 408

  Fly   569 TGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSH-VAPC-----------IKVPTNANM---- 617
            :...|:..:|.||||.||.|..|:||..||.....: ..||           ..:.:||::
Mouse   409 SVTFCDPSNGDCPCKPGVAGPHCDRCMVGYWGFGDYGCRPCDCAGSCDPLTGDCISSNADVDWYH 473

  Fly   618 -IQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASPKKL-NLNKFCMEDYAILAKV---IG 677
             :.|..:.......:.:::|..|...   .::.|||:...:.| |...||...|:.:.|:   ..
Mouse   474 EVPAFHSMHNKSEPSWEWEDEQGFSA---LRHSGKCECKEQVLGNPKAFCGMKYSYVLKIKILSA 535

  Fly   678 HDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSLLGRGNMMLLVPRK--SIECQC 740
            ||:.|.                 .|:|::.   :..:..|...:| ||. ..|.|..  :..|.|
Mouse   536 HDKGSH-----------------AEVNVKI---KKVLKSTKLKIL-RGK-RTLYPESWTNRGCTC 578

  Fly   741 PKIKLNKSYLILGRDSEAAPGYLAIGPSSVVLEWKDEWSLRMKRFQRR 788
            |.:.....||:.|.: :...|.|.:...|.|..||.....|:....:|
Mouse   579 PILNPGLEYLVAGHE-DVRTGKLIVNMKSFVQHWKPALGRRVMHILKR 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	57/236 (24%)
		EGF_Lam	<458..484	CDD:238012	14/25 (56%)
		EGF_Lam	498..555	CDD:238012	28/56 (50%)
		EGF_Lam	560..608	CDD:238012	21/54 (39%)
		NTR_netrin-1_like	661..791	CDD:239634	29/133 (22%)
Ntn4	NP_067295.2	Laminin_N	34..260	CDD:459653	69/372 (19%)
		EGF_Lam	261..320	CDD:238012	27/83 (33%)
		Laminin_EGF	332..392	CDD:395007	28/59 (47%)
		EGF_Lam	395..446	CDD:214543	21/50 (42%)
		NTR_netrin-4_like	517..626	CDD:239633	29/132 (22%)