DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetB and ntng1a

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_009295804.2	Gene:	ntng1a / 569075	ZFINID:	ZDB-GENE-091118-13	Length:	545	Species:	Danio rerio

Alignment Length:	635	Identity:	147/635 - (23%)
Similarity:	219/635 - (34%)	Gaps:	254/635 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 CGAQQPERYCELLRDGNAGECRS-C----EQQRYGPAALTDLNNPSNVTCWRSGA-VNVPHDPDS 120
            || ..||.||.|   .|...|.: |    ::..:.|..:.|:...:..|.|:|.: ...|
Zfish    72 CG-DPPETYCTL---ENPYMCNNECDAATDELAHPPELMFDIVGRNPTTFWQSTSWKKYP----- 127

  Fly   121 APPDNVTLTLSLGKKYELT-YISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQC-QKFYGR 183
             .|..|.:|||..|..||| .|.::|  .|.||:.:.:.||.|:|::|||:|||::.| ..|...
Zfish   128 -KPLAVNITLSWNKTIELTDDIVITF--ESGRPEQMVLEKSLDYGRSWQPYQFYATDCLDAFTME 189

  Fly   184 PDRAK-ISKFNEQEARCINSQHDTG-----------GAAQRFAFNTLEGRPSAND-------LDS 229
            |...| |::....:..| ..::..|           ....|||   |...|..::       ||:
Zfish   190 PKTMKDITQHTLLDIIC-TEEYSRGYVWKNDKTVRFEIRDRFA---LFAGPKLHNMASLYGQLDT 250

  Fly   230 SLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYN 294
            :..|:|:.|.||:|:         :||:........||...||
Zfish   251 TKNLRDFFTITDLRI---------RLLRPATGATMVDENNLSR---------------------- 284

  Fly   295 LQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPP 359

Zfish   285 ----------------------------------------------------------------- 284

  Fly   360 QQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGT 424
                                            .:||:||..|.||||||.||:.|:..
Zfish   285 --------------------------------YYYAISDIKVHGRCKCNLHANSCIYD------- 310

  Fly   425 ALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRAT- 488
                                           |..:||.|:|||.||:|.|||..:..|.|...:
Zfish   311 -------------------------------KEKLTCECEHNTTGPDCGRCKRNFQARAWSAGSY 344

  Fly   489 ----DNDANECKM-------CQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCRE 542
                ...||.|..       |:|..|:.||.: :|:      ::..:|.:|:|:|.|::||.|:.
Zfish   345 LPIPKGTANICMANYAGPVNCECYNHSNRCSY-IEV------LNAVICVSCKHNTRGQHCHLCKL 402

  Fly   543 GYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGY--------Q 599
            ||||:||..|:...:|..|:|:|.||....||. :|.|.||||.||..|:.|..||        :
Zfish   403 GYYRNATAKPDDENICIDCNCNPFGSESDRCNG-TGYCRCKEGATGAMCHECLPGYLWDNGCKSR 466

  Fly   600 QTRSHVAPCIKVPTNANMIQAE-----------------SAGGGGGGGTG 632
            ...|.:..|.......|.::.:                 ..||.||..:|
Zfish   467 VCDSELLRCQNGGVCVNYVRCQCPPAYTGLLCEKPRCEKEPGGCGGSDSG 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	62/225 (28%)
		EGF_Lam	<458..484	CDD:238012	13/25 (52%)
		EGF_Lam	498..555	CDD:238012	21/56 (38%)
		EGF_Lam	560..608	CDD:238012	20/55 (36%)
		NTR_netrin-1_like	661..791	CDD:239634
ntng1a	XP_009295804.2	Laminin_N	69..296	CDD:306548	71/367 (19%)
		EGF_Lam	297..343	CDD:238012	23/83 (28%)
		EGF_Lam	355..413	CDD:238012	21/64 (33%)
		EGF_Lam	421..468	CDD:238012	19/47 (40%)
		EGF_CA	<475..499	CDD:238011	2/23 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910