Protein Alignment NetB and ush2a

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: XP_009291422.2
• Gene: ush2a / 568982
• ZFINID: ZDB-GENE-060503-794
• Length: 5243
• Species: Danio rerio
• Alignment Length: 715
• Identity: 159/715 - (22%)
• Similarity: 241/715 - (33%)
• Gaps: 247/715 - (34%)

  Fly     5 TGTRMGLLLPIILALAIGSSAAGISSNDPCYFEGK-------PRKCLPSFVNAAYGNPV-----Q 57
            |.|..||:..|   .:.|:...|.|||....|.|:       |:......:...|....     |
Zfish   250 TQTLAGLVDDI---TSDGAVWIGRSSNGSNQFIGRMQDFRFYPKTLTNREIEEVYTGQFPHLHSQ 311

  Fly    58 ASSVCGAQQP------ERYC--ELLRDGNAGECRSCEQQRYGPAALTDLNNPSNVTCWRSGAVNV 114
            ::.:|.|..|      ||||  ....|....:.....|..:   .|..:|:....|.|.|...
Zfish   312 STCLCPASHPRVHPLVERYCIPNAANDTTHNKVLRLNQDAH---PLDYINDNDIGTTWISSIF-- 371

  Fly   115 PHDPDSAPPD-NVTLTLSL-GKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQC 177
               |.....| .:|:|:.| ..:|::.|:.|.|.  :.:|:::.|.:.:.....|:.:||.:..|
Zfish   372 ---PSIELLDKGITITIDLENGQYQVFYVILQFL--NAQPEAVRIQRKTVGSSEWKDWQFLAKNC 431

  Fly   178 QKFYGRPDRAKISKFNEQEARCINSQHDTGGAAQRFAFNTLEG----RPSANDLDSSLVLQDWVT 238
             .::|..|...:.  :.....|:....|...:.....|:.|..    ||..||..:|..||::|.
Zfish   432 -SYFGMEDNGALD--SPDSVNCLQLPSDIPYSRGNITFSMLTPEPNLRPGYNDFYNSAALQEFVR 493

  Fly   239 ATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADA 303
            ||.:|:..|                                      |:     |:.||
Zfish   494 ATHVRIQLH--------------------------------------GQ-----YHTQD------ 509

  Fly   304 GYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPP 368
                                                               ||.|.:.
Zfish   510 ---------------------------------------------------ATVPFRH------- 516

  Fly   369 GKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQ 433
                                   ::|||.:..:.|||:|:|||..|
Zfish   517 -----------------------RYYAVDEITISGRCECHGHADSC------------------- 539

  Fly   434 DEDTPSAPSLANHFGRSTQMSAKLTMTCAC--KHNTAGPECERCKPFYFDRPWGRATDNDANECK 496
              ||..:|                 ..|||  :.:|.|..||||.|.:.|:|:.......|..|:
Zfish   540 --DTSVSP-----------------YRCACLPESHTHGANCERCIPLFNDKPFRPGDQIQAFNCR 585

  Fly   497 MCQCNGHARRCRFNLELYKLSG---RVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVC 558
            .|||.|||..|.:|..|....|   |..||||.:|.|:||||.|..||..:||:.........||
Zfish   586 PCQCYGHASSCHYNSSLDPHPGEHFRGGGGVCDDCTHNTTGRNCERCRSLFYREVGALLWATDVC 650

  Fly   559 KRCDCHPVGSTGKT--CNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAP-CIKVPTN-ANMIQ 619
            |.|:||..|:...:  |..:.|||.||..|:|..||:|..|:.:.:|.:|. |.....| |..:|
Zfish   651 KACECHSAGTINASLHCEPIGGQCKCKRHVSGRQCNQCQHGFYKLQSALADGCRACNCNTAGTVQ 715

  Fly   620 AESAGGGGGGGTGDYKDGGGSQVEE--MKKYCGKCKASPKKLN-----------------LNKFC 665
            .:..         .::|.|..|.:.  :...|.:|....|.||                 |::||
Zfish   716 PDIT---------CHQDSGQCQCKANVIGLTCDRCNYGFKFLNHTNPDGCISCGCDPWGSLHQFC 771

  Fly   666  665
            Zfish   772  771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	51/249 (20%)
		EGF_Lam	<458..484	CDD:238012	11/27 (41%)
		EGF_Lam	498..555	CDD:238012	26/59 (44%)
		EGF_Lam	560..608	CDD:238012	18/50 (36%)
		NTR_netrin-1_like	661..791	CDD:239634	3/5 (60%)
ush2a	XP_009291422.2	None