Protein Alignment NetB and ntn4

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_001417912.1
• Gene: ntn4 / 561440
• ZFINID: ZDB-GENE-050310-1
• Length: 593
• Species: Danio rerio
• Alignment Length: 782
• Identity: 197/782 - (25%)
• Similarity: 295/782 - (37%)
• Gaps: 248/782 - (31%)

  Fly    41 RKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNAGECRSCE----QQRYGPAALTDLNNP 101
            |.|.|...|.|.|.|:|..|.||:..||::|....|....:|..|:    |..:.|:::||....
Zfish    31 RVCNPRMGNLAVGRPIQTVSQCGSTSPEQFCMYRPDSCVLDCEICDASVSQHAHSPSSMTDSPFK 95

  Fly   102 SNVTCWRSGAVNVPHDPDSAPPDNV-TLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQ 165
            ..:|.|:           |||...: ||.|.|..::..|::.:.|  .||||.::||.:|.||||
Zfish    96 QPLTWWQ-----------SAPGTAIETLQLDLEVEFYFTHLIIIF--MSPRPAAMAIDRSRDFGQ 147

  Fly   166 TWQPFQFYSSQCQKFYGRPDRAK-ISKFNEQEARCINSQHDTGGAAQRFAFNTLEGRPSANDLDS 229
            ||.....:|..|.:.....|..: .:|::..|. |.|.:
Zfish   148 TWSLLMLFSHNCSEVSSLEDGQRCTAKYSSAEP-CTNGE-------------------------- 185

  Fly   230 SLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYN 294
                          |::..|
Zfish   186 --------------VIYRAL--------------------------------------------- 191

  Fly   295 LQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPP 359
                           .|.:.|:        .|::|..|:                   |..|...
Zfish   192 ---------------SPYERLD--------PYSTDARSL-------------------LGVTNVR 214

  Fly   360 QQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGT 424
            .:        .:.|.|...|.|.|:|.|    ..||:||..:.|.|.|:|||.:||.|
Zfish   215 IR--------LLQPHSCPCPIADANAAT----PRYAISDLILKGGCLCHGHADQCVPT------- 260

  Fly   425 ALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATD 489
                   |...::.:       ||:.. :..|    |.|:|:|||..||||...|.|||| ||.|
Zfish   261 -------GGKHNSKT-------FGKHV-VHGK----CLCRHHTAGDHCERCHRLYNDRPW-RAAD 305

  Fly   490 ---NDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKP 551
               .:||:|..|:|||||..|.|:..::..||:..|||| :|.|:|||::|.:|:.|:|||..||
Zfish   306 GLTGEANQCVECKCNGHAESCHFDESVWLRSGQQHGGVC-DCLHNTTGQHCQHCQSGFYRDPEKP 369

  Fly   552 PNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSH-VAPC-----IK 610
            ......|..|.|:.|||:  .|...:|:|.||.||.|..|.:|..||.....: ..||     ..
Zfish   370 STAPDSCTPCMCNHVGSS--YCKPDNGECVCKPGVAGRHCEQCMLGYWGLDEYGCKPCQCAGDCD 432

  Fly   611 VPTNANMIQAESAGGGGGGGTGDYKDGGGS------QVEEM---KKYCGKCKASPKKLNLNK-FC 665
            ..|...||::||             |...:      :.||:   ..:..||....:.|..:| ||
Zfish   433 PYTGDCMIRSES-------------DDNSTAENHLFRTEELFSALSHPDKCICKQQALGNSKVFC 484

  Fly   666 MED--YAILAKVIG-HDRASQ-DISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSLLGRGN 726
            ...  ||:..:|:| ||:.|. ::..:...:...|...:.....:|::..:.||        ||
Zfish   485 NAKYAYAVKVRVLGAHDKGSHAEVDVKILKVLWDNTRLRLSRGSRTLYPESWMS--------RG- 540

  Fly   727 MMLLVPRKSIECQCPKIKLNKSYLILGRDSEAAPGYLAIGPSSVVLEWKDEWSLRMKRFQRRARK 791
                       |.||.:.....||::|.: :...|...:...|:|..|:.  ||..|..|....|
Zfish   541 -----------CTCPVLFPGLEYLVVGHE-DVRKGRPVVNMKSIVKPWRA--SLSRKVHQLLKTK 591

  Fly   792 CS 793
            ||
Zfish   592 CS 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	54/225 (24%)
		EGF_Lam	<458..484	CDD:238012	13/25 (52%)
		EGF_Lam	498..555	CDD:238012	27/56 (48%)
		EGF_Lam	560..608	CDD:238012	17/48 (35%)
		NTR_netrin-1_like	661..791	CDD:239634	30/134 (22%)
ntn4	NP_001417912.1	Laminin_N	33..246	CDD:459653	71/365 (19%)
		EGF_Lam	248..305	CDD:238012	29/83 (35%)
		Laminin_EGF	317..376	CDD:395007	27/59 (46%)
		EGF_Lam	379..422	CDD:214543	17/44 (39%)
		NTR_netrin-4_like	480..591	CDD:239633	30/133 (23%)