Protein Alignment NetB and si:dkey-202e22.2

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: XP_021335550.2
• Gene: si:dkey-202e22.2 / 560497
• ZFINID: ZDB-GENE-141215-27
• Length: 642
• Species: Danio rerio
• Alignment Length: 789
• Identity: 185/789 - (23%)
• Similarity: 282/789 - (35%)
• Gaps: 253/789 - (32%)

  Fly    41 RKCLPSFVNAAYGNPV-------QASSVCGAQQPERYCELLRDGNAGECRSCEQQRYGPAALTD- 97
            |.|.|...|.|.|..:       ..||.|...||.                |:.:.:.||.:.|
Zfish    35 RACSPPMGNLASGRTLFTLTSCCTNSSSCLPTQPR----------------CQAELHPPALMADD 83

  Fly    98 -LNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSS 161
             ..:|.  |.|.|.|         |..:...:.|.|..::.::::.:.||  ||||.::.:.:|.
Zfish    84 PFTHPD--TWWGSTA---------ASGEQEEIRLDLETRFCMSHVVMLFC--SPRPAAMRLERSQ 135

  Fly   162 DFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHDTGGAAQRFAFNTLEGRPSAND 226
            ||||||:..:.::..|.:.:|.||..      .|......|::.:.....|.
Zfish   136 DFGQTWETLKLFARNCTEMFGLPDDV------SQSGAVCTSRYSSALPCSRG------------- 181

  Fly   227 LDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEY 291
                            .|:|..:.|                  ||              |..|.|
Zfish   182 ----------------EVIFRSIGL------------------GS--------------GIVDPY 198

  Fly   292 DYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAAT 356
                              .|:....|...:|.:......:..:                ||...:
Zfish   199 ------------------SPQALSRLTVTNLRIQLLKSQQCPI----------------SKGQRS 229

  Fly   357 TPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSG 421
            .|.|..|...|    |.||.:..:...|:..|. |..:||......|.|.|:|||..|:
Zfish   230 IPEQSNPSFLP----TVPSRSLKAPIPSSDPLD-SAPFAVYSLLAKGTCLCHGHAEHCL------ 283

  Fly   422 SGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGR 486
                  .:::|||               |.|.|..::..|.|.|:|||..||||...|.|:||..
Zfish   284 ------PENEGQD---------------SLQQSNVVSGKCVCAHHTAGDHCERCALLYNDKPWRA 327

  Fly   487 A--TDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDAT 549
            |  :..::|.|:.|:|:||:..|.|:..::..:|.:|||||.:|||:|.||.|..||.||:|...
Zfish   328 ANGSSGESNSCQKCECHGHSESCHFSQRVWLSTGGISGGVCDHCQHNTVGRRCQRCRTGYHRHPA 392

  Fly   550 KPPNHRKVCKRCDCHPVGST-------GKTCNHLSGQCPCKEGVTGLTCNRCARGY-----QQTR 602
            :|.|....|.||.|.|.||.       ...|:..||||.||.||.|.||:.|..|:     :..:
Zfish   393 RPLNSPHACTRCWCDPAGSVLVHSADEMPWCHPRSGQCHCKPGVGGTTCSHCLPGHWGFGEEGCK 457

  Fly   603 SHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKK-------------------- 647
            ..|.|....|...:.:.::       |....|....|.::.|:..
Zfish   458 PCVCPLTCDPITGHCLDSK-------GSVRLYNVPIGGKIPELSHFKPQEDERAWPKELAVSALY 515

  Fly   648 YCGKCKASPKKL----NLNKFCMEDYAILAKVI-GHDRASQDISTEKFSIERQNEIYKYEINIQT 707
            :.|||....|||    :|.|. ...|.|.|.|: .||:.:..:..               :.::.
Zfish   516 FTGKCSCKEKKLKSAADLCKM-KHAYVIKASVLTAHDKGTHAVVL---------------VKVRK 564

  Fly   708 IFKRNPMS---GTTS----SLLGRGNMMLLVPRKSIECQCPKIKLNKSYLILGRDSEAAPGYLAI 765
            :|:...::   ||.:    |...||            |.||.:....|||:.|.: |...|.|.:
Zfish   565 VFRSGKLTLSQGTHTLYPLSWTSRG------------CTCPILNPGASYLLAGPE-EVDSGRLLV 616

  Fly   766 GPSSVVLEW 774
            ...|:|:.|
Zfish   617 TMQSLVVPW 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	46/228 (20%)
		EGF_Lam	<458..484	CDD:238012	12/25 (48%)
		EGF_Lam	498..555	CDD:238012	26/56 (46%)
		EGF_Lam	560..608	CDD:238012	21/59 (36%)
		NTR_netrin-1_like	661..791	CDD:239634	27/122 (22%)
si:dkey-202e22.2	XP_021335550.2	None