DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetB and ntng2a

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_009302069.1	Gene:	ntng2a / 560014	ZFINID:	ZDB-GENE-081105-186	Length:	1256	Species:	Danio rerio

Alignment Length:	618	Identity:	131/618 - (21%)
Similarity:	224/618 - (36%)	Gaps:	164/618 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 TDLNNP-SNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFK 159
            ||:::| |.||......|     ||:.||                       |.|..|......|
Zfish   691 TDVDSPTSGVTLLTGEPV-----PDATPP-----------------------PESKPPPETKEEK 727

  Fly   160 SSDFGQTWQPFQFYSSQCQKFYG-----RPDRAKISKFNEQE-------ARCINSQHDTGGAAQR 212
            :....:.....|..|...:|...     :.|:.:....||.|       :..:..:.|.
Zfish   728 TEAKDKDTPEIQAPSEVEEKIEELLVEIKEDKTETDLVNEDEDAPDIKPSSEVEEKRDV------ 786

  Fly   213 FAFNTLEGRPSANDLDSSLVLQDWVTATDIRV---VFHRLE-LP------PQLLKVKNANAFSDE 267
             ....::.:.:|.:|::    :| ..|:||::   |..::| ||      .|...|:|.:..:.:
Zfish   787 -PLVEIKEKETATNLEN----ED-KDASDIKLPSEVEEKMEDLPVEIQEEKQKTNVENEDKDTPD 845

  Fly   268 MGGSREEDEDDDADLELDGE--QDEYDYNLQDNDSADAG-----YDEYEEP------KKHLELDD 319
            :..|.|.:|..:..|   ||  :|:....|.|.|:.|..     .::.|:|      :|..:.|:
Zfish   846 IKPSSEVEEKSEVPL---GETTEDKPSTKLDDKDTLDVKTSPEIEEKNEDPLVETKEEKTTKKDE 907

  Fly   320 DHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAAS 384
            |      |||.:...|.:...:....||       ..|..::....||..|::       |....
Zfish   908 D------ASDSKPPFKVRENSEEPKMEK-------PETNLEKKDNNTPDIKLS-------SEVGE 952

  Fly   385 AVTLPISQ--------HYAVSDFAVGGRCKCN--GHASECVATVSSGSGTALSDQDDGQDEDTPS 439
            ...|||::        :....|.....|...:  |..||    .|..|.|||:.:...:|.:...
Zfish   953 KSELPIAETKEKKEIKNLEKKDKDAPDRKPLSKVGENSE----ESKESKTALNSEKKDKDAEASV 1013

  Fly   440 APSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPF--YFDR-------PWGRATD------ 489
            :..:.|.....|:.:.|...:...|......|..:.|.|  |..:       |.|..|.
Zfish  1014 SGDIKNDKLDKTREAEKTEKSKEAKEEKKEKEKHKEKEFKEYEKKVVARILIPGGPKTQLSRIAY 1078

  Fly   490 ---NDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKP 551
               .|      |:||||:.||.: ::...:.      .|.:|:|:|.|:.|.:||.||:|:|:..
Zfish  1079 IKFQD------CECNGHSNRCSY-IDFINIV------TCVSCKHNTRGQNCQHCRLGYFRNASAE 1130

  Fly   552 PNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNAN 616
            .:...||..|:|:.:||....||. :|.|.|::|..|..|..|..||...:.    |:....:..
Zfish  1131 LDDENVCIECNCNQLGSIHARCND-TGFCQCRDGTAGQKCEDCLPGYTWKQG----CVPNVCDDE 1190

  Fly   617 MIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYC 649
            .:..::               |||.::..|..|
Zfish  1191 FLLCQN---------------GGSCIQNQKCVC 1208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	35/187 (19%)
		EGF_Lam	<458..484	CDD:238012	5/34 (15%)
		EGF_Lam	498..555	CDD:238012	19/56 (34%)
		EGF_Lam	560..608	CDD:238012	15/47 (32%)
		NTR_netrin-1_like	661..791	CDD:239634
ntng2a	XP_009302069.1	Laminin_N	68..291	CDD:295486
		EGF_Lam	294..340	CDD:238012
		E_Pc_C	<377..483	CDD:284226
		EGF_Lam	1084..1132	CDD:238012	19/54 (35%)
		Laminin_EGF	1140..1187	CDD:278482	16/51 (31%)
		EGF_2	1187..1217	CDD:285248	5/37 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900