DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and lamc3

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_687343.5	Gene:	lamc3 / 558958	ZFINID:	ZDB-GENE-060531-121	Length:	1643	Species:	Danio rerio

Alignment Length:	769	Identity:	226/769 - (29%)
Similarity:	306/769 - (39%)	Gaps:	250/769 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILALAIGSSAAGISSNDPCYFE-GKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNA 79
            :|.|...|.....:..|.||.| |.|..|||.|.|||:.:.|..|::||. .||.||  ::.|:.
Zfish     9 LLLLLFASVYFVFAGMDSCYDENGVPSLCLPKFENAAFNHSVMVSNMCGI-PPEDYC--MQTGST 70

  Fly    80 GECRSCE----QQRYGPAALTDLNNPSNVTCWRSGAV--NVPHDPDSAPPDNVTLTLSLGKKYEL 138
            ..|..|:    :.......|||.:.....|.|:|.::  .|.:      |::|.:||.|||.:|:
Zfish    71 RSCHHCDAFDSELNRNATYLTDFHTDEEPTWWQSQSMFYGVQY------PNSVNITLHLGKAFEI 129

  Fly   139 TYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISK-FNEQEARCINS 202
            ||:.|.|  .:.||:|.||:|.:|....|||:|:||:.|:|.|||.::..|.. .||:...|.:.
Zfish   130 TYVRLKF--YTSRPESFAIYKRTDENGPWQPYQYYSASCRKTYGRDNKGFIRPGDNERTPLCTDE 192

  Fly   203 QHD----TGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANA 263
            ..|    |||   ..||:||||||||.:.|.|||||||||||||.:...||            |.
Zfish   193 FSDISPLTGG---NVAFSTLEGRPSAYNFDQSLVLQDWVTATDILISLDRL------------NT 242

  Fly   264 FSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYAS 328
            |.||.                                       :::.|
Zfish   243 FGDEF---------------------------------------FKDAK---------------- 252

  Fly   329 DGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQH 393
                 |.|                                                      |..
Zfish   253 -----VLR------------------------------------------------------SYF 258

  Fly   394 YAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLT 458
            ||:|||:|||||||||||||||                            .|..|||
Zfish   259 YAISDFSVGGRCKCNGHASECV----------------------------VNEEGRS-------- 287

  Fly   459 MTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGG 523
             .|.|:|||||.:|:.|.|||.||||.|||.:.||||..|.|:|.|..|.|::|.|:.:|:  ||
Zfish   288 -VCVCEHNTAGVDCQLCAPFYQDRPWARATAHSANECVRCNCSGLADECVFDVEQYRSTGQ--GG 349

  Fly   524 VCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTG 588
            .|..|:.:|.|.:|..|||.|:|.:...|     |:.|:|:.:||....|: ..|.|.|...|:|
Zfish   350 RCLGCRENTAGPHCEQCRENYFRSSALQP-----CQNCNCNALGSVSLQCD-ADGVCVCWPSVSG 408

  Fly   589 LTCNRCARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCK 653
            :.|:.|..|:....         |....:...:..|..|.....|.:....:.||...  |.:||
Zfish   409 VKCDICKSGFHSLG---------PGGCRLCDCDERGSVGVCSAEDGRCHCKANVEGQS--CNRCK 462

  Fly   654 ASPKKLNL--------NK-FCMEDYAILAKVIGHDRASQDISTEKFSIERQNEIYKYEINIQTIF 709
              |...||        || ||          .||..|.       ||..:...||     |.:.|
Zfish   463 --PGSFNLQLENPDGCNKCFC----------FGHSLAC-------FSSNQYTPIY-----ITSDF 503

  Fly   710 KRNP--MSGTTS-----SLLGRGNMMLLVPRKSIE--CQCPKIKLNKSYLILGR 754
            ..:|  ..|..|     ||:.:...:.|:|.:...  .:.|...|....|..||
Zfish   504 LEDPDGWKGVFSRAHEQSLIWKEGEVYLLPYREENGFYKAPDKYLGNMLLSYGR 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	92/235 (39%)
		EGF_Lam	<458..484	CDD:238012	14/25 (56%)
		EGF_Lam	498..555	CDD:238012	22/56 (39%)
		EGF_Lam	560..608	CDD:238012	13/47 (28%)
		NTR_netrin-1_like	661..791	CDD:239634	26/112 (23%)
lamc3	XP_687343.5	Laminin_N	46..268	CDD:278484	96/361 (27%)
		EGF_Lam	269..314	CDD:238012	32/81 (40%)
		Laminin_EGF	326..382	CDD:278482	23/62 (37%)
		EGF_Lam	382..426	CDD:214543	14/53 (26%)
		Laminin_EGF	429..476	CDD:278482	11/50 (22%)
		Laminin_B	540..659	CDD:278481	5/18 (28%)
		EGF_Lam	710..751	CDD:238012
		Laminin_EGF	814..861	CDD:278482
		EGF_Lam	871..921	CDD:238012
		Laminin_EGF	923..971	CDD:278482
		EGF_Lam	970..1010	CDD:238012
		ApoLp-III_like	1233..1386	CDD:304399
		PspA	1388..1607	CDD:224755
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	2	1.870