DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and lamb2l

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_005162178.1	Gene:	lamb2l / 553337	ZFINID:	ZDB-GENE-030131-4205	Length:	1836	Species:	Danio rerio

Alignment Length:	803	Identity:	181/803 - (22%)
Similarity:	267/803 - (33%)	Gaps:	307/803 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILALAIGSSAAGISSNDPCYFEGKPRKCLPSFVNAAYGNPVQ--ASSVCGAQQPERYCELLRDGN 78
            :|.|.:.:.|..:.|......:|   .|.|:..|...|..:.  .||.||...||.||.:....:
Zfish     8 VLLLVLPALAQDLPSAPHGCMDG---SCYPATGNLLIGRAINLTTSSTCGLDGPEPYCIVSHLKD 69

  Fly    79 AGECRSCEQQR-YGPAALTDLNNPSNV----------TCWRSGAVNVPHDPDSAPPDNVTLTLSL 132
            :.:|..|:.:. |......|.:...||          |.|:  |||        ..:||::.|:|
Zfish    70 SEKCFICDSENPYDANYHRDSHRVENVIYPMDSTGELTWWQ--AVN--------GEENVSVRLNL 124

  Fly   133 GKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQ-- 195
            ..::..|::.:.|  ::.||.::.|.:|||||:||:.:::::..|.|.:.|.....:...:|.
Zfish   125 EAEFHFTHLIMKF--KTFRPAAMIIERSSDFGRTWRIYRYFAYNCTKTFPRVPAHSLRFIDEVIC 187

  Fly   196 EARCINSQHDTGGAAQRFAFNTLEGRPSANDLDS-SLVLQDWVTATDIRVVFHRLELPPQLLKVK 259
            |.|..:.:..|.|   ...:..|:  |:.:..|. ||.:||.:..|::|:.|.:|
Zfish   188 EERYSDIEPSTDG---EVIYKVLD--PAIHVKDPYSLDIQDLLRITNLRINFTKL---------- 237

  Fly   260 NANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHL 324
                                             :.|.||                        .|
Zfish   238 ---------------------------------HTLGDN------------------------LL 245

  Fly   325 DYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLP 389
            |...|              ..:|:|
Zfish   246 DRRPD--------------VLQKYY---------------------------------------- 256

  Fly   390 ISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMS 454
                ||:.:..|.|.|.|.||||||....                             |.:|:.|
Zfish   257 ----YALYELVVRGSCFCYGHASECAPVP-----------------------------GVTTRDS 288

  Fly   455 AKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGR 519
            ..:...|.|||||.|..||||:.||.|.||..|..::|:.|:.|.||||:.:|.|::.:|..:|.
Zfish   289 GMIHGRCVCKHNTVGLNCERCRDFYHDAPWRPAETDNAHTCRECNCNGHSNQCHFDMAVYLATGN 353

  Fly   520 VSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGST--------------- 569
            ||||||.||.|:|.||.|..|:..||:|..|.......|..|||.||||.
Zfish   354 VSGGVCNNCLHNTMGRNCESCKPFYYQDPEKDIRDPAACVPCDCDPVGSVEGGVCDSHTDLDLGM 418

  Fly   570 -----------------------------------------------GKTCNHLSGQCPCKEGVT 587
                                                           |..|:.:||.|.||..||
Zfish   419 IGGQCRCKQNVRGQRCDYCKEGHYGLSLDDPLGCQPCNCDPRGITTLGVPCDQISGDCSCKRYVT 483

  Fly   588 GLTCNRCARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKC 652
            |..||:|...|......:|.|  .|.|.                    |.||:.........|:|
Zfish   484 GRYCNQCLPEYWGLSHDLAGC--RPCNC--------------------DFGGATSSRCMMDSGQC 526

  Fly   653 KASPKKLNLNKFCMEDYAILAKVIGHDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGT 717
            ...|                 .:||  |...::....|....  :.||||  .:.:..|:|...|
Zfish   527 DCRP-----------------HLIG--RQCSEVQPAFFCASL--DYYKYE--AEAVMGRSPEDLT 568

  Fly   718 TSSLLGRGNMMLLVPRKSIECQC 740
               |.|.       ||...|..|
Zfish   569 ---LPGS-------PRPQAETDC 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	59/239 (25%)
		EGF_Lam	<458..484	CDD:238012	14/25 (56%)
		EGF_Lam	498..555	CDD:238012	27/56 (48%)
		EGF_Lam	560..608	CDD:238012	22/109 (20%)
		NTR_netrin-1_like	661..791	CDD:239634	17/80 (21%)
lamb2l	XP_005162178.1	Laminin_N	41..266	CDD:306548	66/366 (18%)
		EGF_Lam	267..320	CDD:238012	27/81 (33%)
		EGF_Lam	332..384	CDD:238012	26/51 (51%)
		Laminin_EGF	395..452	CDD:278482	7/56 (13%)
		EGF_Lam	454..505	CDD:238012	16/52 (31%)
		EGF_Lam	506..>545	CDD:238012	11/77 (14%)
		EGF_Lam	816..861	CDD:214543
		Laminin_EGF	864..912	CDD:278482
		Laminin_EGF	910..957	CDD:278482
		Laminin_EGF	960..1016	CDD:278482
		Laminin_EGF	1019..1063	CDD:278482
		Laminin_EGF	<1089..1129	CDD:278482
		Laminin_EGF	1122..1175	CDD:278482
		Laminin_EGF	1175..1215	CDD:278482
		SMC_N	<1243..1826	CDD:330553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910