DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and trol

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001027038.3	Gene:	trol / 45320	FlyBaseID:	FBgn0284408	Length:	4479	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	110/587 - (18%)
Similarity:	182/587 - (31%)	Gaps:	213/587 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 AAY-GNPVQASSVCGAQQPERYCEL-------------LRDGNAGE-CRSCEQQRYGPAALTDLN 99
            |.| |||:.|..:| .:.|:..|.:             .:|...|| |.:|:.:.:   .|....
  Fly  1975 AGYQGNPLAAGGIC-RRIPDTSCNVDGTYSVHSNGTCQCKDSVIGEQCDTCKSKSF---HLNSFT 2035

  Fly   100 NPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFG 164
            ....:.|:.|| |.:..|..:...|.||.|....:......:..::  ..|.||::.:..:::
  Fly  2036 YTGCIECFCSG-VGLDCDSSTWYRDQVTSTFGRSRVDHGFVLVTNY--MQPTPDTVPVSMAAE-- 2095

  Fly   165 QTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHDTGGAAQRFAFNTLEGRPSANDLDS 229
                      .....|.|..|::..:.:....|..:.::..:.|....:   ||...|..|.:.|
  Fly  2096 ----------PNALSFIGSADQSGNTLYWSLPAAFLGNKLSSYGGKLTY---TLSYSPLPNGIMS 2147

  Fly   230 SLVLQDWV--TATDIRVVFHR-LELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEY 291
            .....|.|  :..|:|::.:| .::.|.:     ||.:|.|:
  Fly  2148 RNSAPDVVIKSGEDLRLIHYRKSQVVPSV-----ANTYSVEI----------------------- 2184

  Fly   292 DYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAAT 356
                  .:||....||....::|:        |...||..::.                  :.||
  Fly  2185 ------KESAWQRGDEVVANREHV--------LMALSDITAIY------------------IKAT 2217

  Fly   357 TPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSG 421
            .                 :|:...|:...|||.::
  Fly  2218 Y-----------------TTSTKEASLRQVTLDVA------------------------------ 2235

  Fly   422 SGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGR 486
            :.|.|.         ||.|..:..               |.|.....|..||:|.|.|...|.|.
  Fly  2236 TPTNLG---------TPRAVEVEQ---------------CRCPEGYLGLSCEQCAPGYARDPEGG 2276

  Fly   487 ATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKP 551
            ..   ...|:.|:||||::.|..:.           |.|..|..:|.|..|..|..||..|||:.
  Fly  2277 IY---LGLCRPCECNGHSKYCNSDT-----------GDCEECSDNTEGPSCERCAAGYVGDATRG 2327

  Fly   552 PNHRKVCKRCDCHP-----------VGSTGKTCN---HLSG-------QCPCKEGVTGLTCNRCA 595
            ..:       ||.|           .|:....|.   .:.|       :|.||..|.|..|::|.
  Fly  2328 TIY-------DCQPDEGYPIPSPPAPGNQTLECTAYCQIEGIYDCRGNECLCKRNVIGDQCDQCR 2385

  Fly   596 RG 597
            .|
  Fly  2386 PG 2387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	43/228 (19%)
		EGF_Lam	<458..484	CDD:238012	8/25 (32%)
		EGF_Lam	498..555	CDD:238012	18/56 (32%)
		EGF_Lam	560..608	CDD:238012	14/59 (24%)
		NTR_netrin-1_like	661..791	CDD:239634
trol	NP_001027038.3	LDLa	447..480	CDD:238060
		LDLa	532..564	CDD:238060
		LDLa	571..606	CDD:238060
		LDLa	616..650	CDD:238060
		LDLa	704..739	CDD:238060
		LDLa	813..847	CDD:238060
		LDLa	852..887	CDD:238060
		LDLa	902..936	CDD:238060
		LDLa	956..990	CDD:238060
		LDLa	997..1030	CDD:238060
		LDLa	1033..1067	CDD:238060
		LDLa	1072..1105	CDD:238060
		LDLa	1133..1165	CDD:238060
		LDLa	1182..1215	CDD:238060
		LDLa	1221..1251	CDD:238060
		LDLa	1252..1286	CDD:238060
		LDLa	1292..1326	CDD:238060
		IG	1344..1421	CDD:214652
		Ig	1344..1405	CDD:299845
		LDLa	1439..1473	CDD:238060
		LDLa	1479..1513	CDD:238060
		LDLa	1522..1556	CDD:238060
		IG_like	1566..1649	CDD:214653
		Ig_Perlecan_D2_like	1574..1649	CDD:143220
		Laminin_B	1748..1864	CDD:278481
		EGF_Lam	1935..1989	CDD:238012	7/14 (50%)
		Laminin_B	2113..2238	CDD:278481	32/234 (14%)
		EGF_Lam	<2250..2276	CDD:238012	9/40 (23%)
		EGF_Lam	2284..2333	CDD:238012	19/66 (29%)
		Laminin_EGF	<2369..2399	CDD:278482	8/19 (42%)
		Laminin_B	2465..2587	CDD:278481
		I-set	2686..2772	CDD:254352
		Ig_2	2689..2771	CDD:290606
		Ig	2779..2865	CDD:299845
		IG_like	2798..2864	CDD:214653
		Ig	2882..2965	CDD:299845
		IG_like	2882..2950	CDD:214653
		Ig	2977..3061	CDD:299845
		IG_like	2984..3058	CDD:214653
		IG_like	3074..3152	CDD:214653
		Ig	3086..3153	CDD:299845
		I-set	3155..3243	CDD:254352
		IGc2	3171..3233	CDD:197706
		IG	3371..3447	CDD:214652
		IGc2	3377..3437	CDD:197706
		Ig	3456..3534	CDD:299845
		IG	3465..>3526	CDD:214652
		Ig	3603..3665	CDD:299845
		IG	3610..3683	CDD:214652
		IG	3696..3762	CDD:214652
		Ig	3704..3771	CDD:299845
		LamG	3784..3929	CDD:238058
		EGF	3952..3984	CDD:278437
		LamG	4032..4185	CDD:238058
		Laminin_G_2	4315..4444	CDD:280389
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445135
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10574
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030