DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and dsd

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001263013.1	Gene:	dsd / 43315	FlyBaseID:	FBgn0039528	Length:	1323	Species:	Drosophila melanogaster

Alignment Length:	315	Identity:	73/315 - (23%)
Similarity:	106/315 - (33%)	Gaps:	130/315 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 STAAPSAAASAV-TLPISQHYAVSDF----------AVGGRCKCNGHASECVATVSSGSGTALSD 428
            |||:|...|..: :.|||:.|.||..          :....|:.:...:.|.:..|.| |.||:.
  Fly   748 STASPPLNAKHLDSCPISEEYLVSSVCDQLHNCRACSANLACRWDSEHNRCKSYTSYG-GLALNR 811

  Fly   429 QDDGQDE--DTPSAPSLAN----------------------------HFGRSTQMSAKLTMTCAC 463
            .   |||  .:||..||.|                            .:|:..:.:   |.|..|
  Fly   812 T---QDEVACSPSCASLTNCQNCTEDECIWCQNEQRCVDRNAYTASFPYGQCREWT---TFTAKC 870

  Fly   464 K----HNTA---GP-------------ECERCKPFYFDRPWGRATDNDAN--------------- 493
            :    .:||   |.             .|:.|    .|.|.....||.:|
  Fly   871 RSAPIQSTALAVGSTTALSSAQCGYYNSCQMC----LDDPACGWCDNGSNTGLGRCVVGGALAPY 931

  Fly   494 -------------ECKMCQCNGHA-----RRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYC 540
                         .|..|.||||:     :.|.                 ..|.:.|||.:|..|
  Fly   932 DDTECALKHWFFTSCPRCNCNGHSYCNDQQHCE-----------------QPCNNLTTGAHCEKC 979

  Fly   541 REGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPC-KEGVTGLTCNRC 594
            |.||:.:   |.|..| |:||||:   ..|..|:..:|:|.| .:|:.|..|.:|
  Fly   980 RTGYWGN---PINGGK-CQRCDCN---GQGVYCHPDTGKCFCTTKGIVGDHCEKC 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532
		EGF_Lam	<458..484	CDD:238012	9/45 (20%)
		EGF_Lam	498..555	CDD:238012	17/61 (28%)
		EGF_Lam	560..608	CDD:238012	13/36 (36%)
		NTR_netrin-1_like	661..791	CDD:239634
dsd	NP_001263013.1	CUB	86..212	CDD:238001
		PLN02153	290..582	CDD:177814
		KELCH repeat	308..349	CDD:276965
		Kelch_5	355..391	CDD:290565
		KELCH repeat	358..420	CDD:276965
		KELCH repeat	424..474	CDD:276965
		KELCH repeat	482..531	CDD:276965
		KELCH repeat	535..588	CDD:276965
		PSI	821..870	CDD:279745	7/51 (14%)
		EGF_Lam	948..994	CDD:238012	18/66 (27%)
		EGF_Lam	995..1040	CDD:238012	13/36 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445155
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10574
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030