DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and LAMC1

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_002284.3	Gene:	LAMC1 / 3915	HGNCID:	6492	Length:	1609	Species:	Homo sapiens

Alignment Length:	733	Identity:	225/733 - (30%)
Similarity:	314/733 - (42%)	Gaps:	247/733 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLLLPIILALAIGSSAAGI--SSNDPCYFE-GKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYC 71
            |.|.|::..|| .::|||.  ::.|.|..| |:|::|:|.|||||:...|.|::.||. .||.||
Human    15 GRLWPVLAVLA-AAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGT-PPEEYC 77

  Fly    72 ELLRDGNAGECRSCE-------QQRYGPAALTDLNNPSNVTCWRSGAV--NVPHDPDSAPPDNVT 127
              ::.|..|..:||.       ..::|.|.|||.||.::.|.|:|..:  .|.:      |.::.
Human    78 --VQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQY------PSSIN 134

  Fly   128 LTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKI-SK 191
            |||.|||.:::||:.|.|  .:.||:|.||:|.:.....|.|:|:||..|:..|.:.:|..| :.
Human   135 LTLHLGKAFDITYVRLKF--HTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTG 197

  Fly   192 FNEQEARCINSQHD----TGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELP 252
            .:||:|.|.:...|    |||   ..||:||||||||.:.|:|.|||:|||||||||..:||
Human   198 GDEQQALCTDEFSDISPLTGG---NVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRL--- 256

  Fly   253 PQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLEL 317
                     |.|.||:                                       :.:||
Human   257 ---------NTFGDEV---------------------------------------FNDPK----- 268

  Fly   318 DDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAA 382
                           |:|
Human   269 ---------------VLK----------------------------------------------- 271

  Fly   383 ASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHF 447
                    |.:||:||||||||||||||||||                            :.|.|
Human   272 --------SYYYAISDFAVGGRCKCNGHASEC----------------------------MKNEF 300

  Fly   448 GRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLE 512
            .:         :.|.|||||.|.:||:|.||:.||||.|||...|:||..|.|||.::.|.|:.|
Human   301 DK---------LVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPE 356

  Fly   513 LYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLS 577
            ||:.:|.  ||.|.|||.:|.|.:|..|||.::|     ..:.:.|..|.|.||||....|:..
Human   357 LYRSTGH--GGHCTNCQDNTDGAHCERCRENFFR-----LGNNEACSSCHCSPVGSLSTQCDSY- 413

  Fly   578 GQCPCKEGVTGLTCNRCARGYQQ-TRSHVAPCIKVPTNA-NMIQAESAGGGGGGGTGDYKDGGGS 640
            |:|.||.||.|..|:||..|:.. |.:...||...|:.: :....|:       |....||
Human   414 GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIET-------GRCVCKD---- 467

  Fly   641 QVEEMKKYCGKCKASPKKLNLNK---------FCMEDYAILAKVIGHD---------------RA 681
            .||...  |.:||  |...||..         ||....::....:|:.               ||
Human   468 NVEGFN--CERCK--PGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRA 528

  Fly   682 SQDISTE---KFSIERQN 696
            .|...:|   ::|.|||:
Human   529 EQRDGSEASLEWSSERQD 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	93/238 (39%)
		EGF_Lam	<458..484	CDD:238012	14/25 (56%)
		EGF_Lam	498..555	CDD:238012	23/56 (41%)
		EGF_Lam	560..608	CDD:238012	19/48 (40%)
		NTR_netrin-1_like	661..791	CDD:239634	12/63 (19%)
LAMC1	NP_002284.3	Domain VI	34..285		112/390 (29%)
		LamNT	44..284	CDD:214532	108/379 (28%)
		EGF_Lam	285..330	CDD:238012	29/81 (36%)
		Domain V	286..509		94/282 (33%)
		Laminin_EGF	342..396	CDD:278482	23/60 (38%)
		Laminin_EGF	398..445	CDD:278482	19/47 (40%)
		Laminin_EGF	445..492	CDD:278482	14/61 (23%)
		Domain IV	510..689		8/37 (22%)
		LamB	553..678	CDD:214597
		Domain III	690..1030
		EGF_Lam	724..771	CDD:238012
		EGF_Lam	772..820	CDD:238012
		Laminin_EGF	828..875	CDD:278482
		EGF_Lam	883..933	CDD:238012
		EGF_Lam	935..980	CDD:214543
		EGF_Lam	982..1029	CDD:238012
		Domain I/II	1031..1609
		t_SNARE	1072..1155	CDD:197699
		MA	1091..1302	CDD:214599
		MCP_signal	1123..1255	CDD:304920
		V_Alix_like	1180..>1336	CDD:187408
		Laminin_I	1287..1530	CDD:283627
		SH3BP5	1361..1592	CDD:283045
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870