DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and LAMB1

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_016867690.1	Gene:	LAMB1 / 3912	HGNCID:	6486	Length:	1810	Species:	Homo sapiens

Alignment Length:	849	Identity:	189/849 - (22%)
Similarity:	283/849 - (33%)	Gaps:	288/849 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLPIILALAIGSSAAGISSNDPCYFEG-KPRKCLPSFVNAAYG--NPVQASSVCGAQQPERYC-- 71
            |||::.|   ....|.:.:.:|.:..| ....|.|:..:...|  ..:..:|.||..:||.||
Human    30 LLPVLPA---ALCRARVRAQEPEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIV 91

  Fly    72 -ELLRDGNAGECRSCEQQRYGPAALTD---LNN------PSNVTCWRSGAVNVPHDPDSAPPDNV 126
             .|..|.....|.|  |..|......|   :.|      |:.:..|......|         :||
Human    92 SHLQEDKKCFICNS--QDPYHETLNPDSHLIENVVTTFAPNRLKIWWQSENGV---------ENV 145

  Fly   127 TLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISK 191
            |:.|.|..::..|::.::|  ::.||.::.|.:|||||:||..:::::..|:..:.......:.|
Human   146 TIQLDLEAEFHFTHLIMTF--KTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKK 208

  Fly   192 FNE--QEARCINSQHDTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQ 254
            .::  .::|..:.:..|.|   ...|..|:......|..|..: |:.:..|::|:.|.:|
Human   209 VDDIICDSRYSDIEPSTEG---EVIFRALDPAFKIEDPYSPRI-QNLLKITNLRIKFVKL----- 264

  Fly   255 LLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDD 319
                                                  :.|.||                  |.|
Human   265 --------------------------------------HTLGDN------------------LLD 273

  Fly   320 DHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAAS 384
            ..:.:                    .||:|
Human   274 SRMEI--------------------REKYY----------------------------------- 283

  Fly   385 AVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGR 449
                     |||.|..|.|.|.|.||||||...             ||.:|:...  .:..|
Human   284 ---------YAVYDMVVRGNCFCYGHASECAPV-------------DGFNEEVEG--MVHGH--- 321

  Fly   450 STQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELY 514
                       |.|:|||.|..||.|..||.|.||..|...::|.||.|.||.|:..|.|::.:|
Human   322 -----------CMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVY 375

  Fly   515 KLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGK-TCNH--- 575
            ..:|.||||||.:|||:|.||.|..|:..||:...:.......|:||.|.|.||..: .|:.
Human   376 LATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDSYTD 440

  Fly   576 -----LSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYK 635
                 ::|||.||..|.|..|:.|..|:....|      :.|...........|...||...|.:
Human   441 FSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSS------EDPFGCKSCACNPLGTIPGGNPCDSE 499

  Fly   636 DG---------GGSQVEEMKKYCGKCKASPKKLN----------------LNKFCMEDYAILAKV 675
            .|         |        ::|.:|......|:                ||..|..:
Human   500 TGHCYCKRLVTG--------QHCDQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCFAE------- 549

  Fly   676 IGHDRASQDISTEKFSIERQ-NEI-----------YKY---EINI---QTIFKRNPMSGTTSSLL 722
                  |...|.....|.|| ||:           |.|   |.|:   .:|.:|..:.....|..
Human   550 ------SGQCSCRPHMIGRQCNEVEPGYYFATLDHYLYEAEEANLGPGVSIVERQYIQDRIPSWT 608

  Fly   723 GRGNMMLLVPRKS-IECQCPKIKLNKSYLILGRDSEAAPGYLAIGPSSVVLEWKDEWSLRMKRFQ 786
            |.|  .:.||..: :|.....|..:..|.||.|.....|               |.|...:...|
Human   609 GAG--FVRVPEGAYLEFFIDNIPYSMEYDILIRYEPQLP---------------DHWEKAVITVQ 656

  Fly   787 RRAR 790
            |..|
Human   657 RPGR 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	53/240 (22%)
		EGF_Lam	<458..484	CDD:238012	12/25 (48%)
		EGF_Lam	498..555	CDD:238012	24/56 (43%)
		EGF_Lam	560..608	CDD:238012	18/56 (32%)
		NTR_netrin-1_like	661..791	CDD:239634	33/149 (22%)
LAMB1	XP_016867690.1	Laminin_N	68..293	CDD:278484	63/366 (17%)
		EGF_Lam	295..347	CDD:238012	26/80 (33%)
		EGF_Lam	359..411	CDD:238012	24/51 (47%)
		Laminin_EGF	422..479	CDD:278482	18/62 (29%)
		Laminin_EGF	482..536	CDD:278482	9/61 (15%)
		EGF_Lam	533..>572	CDD:238012	10/51 (20%)
		EGF_Lam	797..842	CDD:214543
		Laminin_EGF	845..893	CDD:278482
		Laminin_EGF	891..938	CDD:278482
		Laminin_EGF	941..997	CDD:278482
		Laminin_EGF	1000..1044	CDD:278482
		Laminin_EGF	1052..1106	CDD:278482
		Laminin_EGF	1108..1156	CDD:278482
		Laminin_EGF	1156..1206	CDD:278482
		PhaP_Bmeg	<1275..1404	CDD:299060
		Mt_ATP_synt	1496..1712	CDD:292332
		GARP	1562..1750	CDD:293336
		Prefoldin	1673..1790	CDD:298833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910