Protein Alignment NetB and LanB2

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_524006.1
• Gene: LanB2 / 39118
• FlyBaseID: FBgn0267348
• Length: 1639
• Species: Drosophila melanogaster
• Alignment Length: 765
• Identity: 223/765 - (29%)
• Similarity: 304/765 - (39%)
• Gaps: 229/765 - (29%)

  Fly    34 CYFE-GKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNAGECRSCEQQRYGPAALTD 97
            ||.. |:|:||||.|:||||...:::::.||.|....:|....:.|...|..|:...:.|:.|||
  Fly    57 CYDPYGRPQKCLPEFINAAYQLQIESTNTCGEQNDNHFCIQTMNQNHKNCEFCKYNDHNPSFLTD 121

  Fly    98 LNNPSNVTCWRSGAV--NVPHDPDSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKS 160
            |::|.:.|.|:|..:  .:.|      |:.|.|||.|||.|::||:.:.|  |||||:|..|:|.
  Fly   122 LHDPQSPTWWQSETMFEGIQH------PNYVNLTLHLGKSYDITYVRILF--RSPRPESFTIYKR 178

  Fly   161 SDFGQTWQPFQFYSSQCQKFYGRPDRAKISK-FNEQEARCINSQHDTGGAAQ-RFAFNTLEGRPS 223
            :.....|.|:||||:.|:..|..||...|.| ..|..|.|.:...|...... ..||:|||||||
  Fly   179 TSESGPWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPS 243

  Fly   224 ANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQ 288
            ..:.:.|..||:||||||||:...||            |.|.||:.|..:
  Fly   244 GINFERSGELQEWVTATDIRITLDRL------------NTFGDELFGDSQ--------------- 281

  Fly   289 DEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKL 353
                                                        |:|
  Fly   282 --------------------------------------------VLK------------------ 284

  Fly   354 AATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATV 418
                                                 |..||:||.|||.|||||||||:||.
  Fly   285 -------------------------------------SYFYAISDIAVGARCKCNGHASKCVP-- 310

  Fly   419 SSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRP 483
                                           ||.|..:.|:.|.|:|||.||:|:||.|.|.|..
  Fly   311 -------------------------------STGMHGERTLVCECRHNTDGPDCDRCLPLYNDLK 344

  Fly   484 WGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYY-RD 547
            |.|:|..:.||||.|.|||.|.:|.|:..|:..:|.  ||.|.:|:.:..|..|..|:|.:| ||
  Fly   345 WKRSTSTEVNECKACNCNGLADKCFFDANLFNRTGH--GGHCLDCRENRDGPNCERCKENFYMRD 407

  Fly   548 ATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVP 612
                   ...|..|.|.||||....||. .|:|.||.||||..|:||...|.|...|
  Fly   408 -------DGYCVNCACDPVGSRSLQCNS-HGKCQCKPGVTGDKCDRCDNNYYQFGPH-------- 456

  Fly   613 TNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMK-KYCGKCKASPKKLNLNK---------FCME 667
             .......:|.|........|.:.|.....|.:: :.|.:||  |...||:|         ||..
  Fly   457 -GCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECK--PGFFNLDKNNRFGCTPCFCYG 518

  Fly   668 DYAILAKVIGHDRASQDISTEKFSIERQN--EIYKYEINIQTIFKRNPMS---GTTSSLLGRGNM 727
            ..:......|:...|...:..||. ||..  ::.:.|::|    |.|..|   |||:    :||
  Fly   519 HTSECMTAPGYSIVSVTSNFNKFK-ERWTAADLNQREVDI----KYNQYSRSIGTTA----QGN- 573

  Fly   728 MLLVPRKSIECQCPKIKLNKSYLILGRDSE---AAPGYLA-IGPSSVVLE 773
                  :.:..|.|...|........||.:   ...|.:| .|.|.|:||
  Fly   574 ------EHVYFQAPDRFLGDQRASYNRDLKFKLQLVGQVANTGVSDVILE 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	86/228 (38%)
		EGF_Lam	<458..484	CDD:238012	14/25 (56%)
		EGF_Lam	498..555	CDD:238012	20/57 (35%)
		EGF_Lam	560..608	CDD:238012	22/47 (47%)
		NTR_netrin-1_like	661..791	CDD:239634	32/131 (24%)
LanB2	NP_524006.1	LamNT	61..296	CDD:214532	99/368 (27%)
		EGF_Lam	298..347	CDD:238012	29/81 (36%)
		Laminin_EGF	359..414	CDD:395007	21/63 (33%)
		EGF_Lam	414..458	CDD:214543	22/53 (42%)
		Laminin_EGF	461..511	CDD:395007	12/51 (24%)
		LamB	572..697	CDD:214597	14/53 (26%)
		EGF_Lam	743..791	CDD:238012
		EGF_Lam	793..836	CDD:214543
		Laminin_EGF	847..897	CDD:395007
		Laminin_EGF	902..953	CDD:395007
		EGF_Lam	956..1001	CDD:214543
		Laminin_EGF	1004..1046	CDD:395007
		SMC_prok_B	<1054..1621	CDD:274008