DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and LAMA5

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_006723859.1	Gene:	LAMA5 / 3911	HGNCID:	6485	Length:	3700	Species:	Homo sapiens

Alignment Length:	706	Identity:	167/706 - (23%)
Similarity:	247/706 - (34%)	Gaps:	269/706 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLPIILALAIGSS-----AAGISSNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPER-- 69
            ||.:.||| :|::     |.|..|..|.||            |.|.|..:.||:.||.:.|.|
Human    22 LLLVGLAL-LGAARAREEAGGGFSLHPPYF------------NLAEGARIAASATCGEEAPARGS 73

  Fly    70 -------YCELLRDGNAGE-------------CRSCEQQRYGPAALTDLNNPSNVT--CWRSGAV 112
                   ||:|:....||.             |.:....:..||     :|..:.|  .|:|
Human    74 PRPTEDLYCKLVGGPVAGGDPNQTIRGQYCDICTAANSNKAHPA-----SNAIDGTERWWQS--- 130

  Fly   113 NVPHDPDSAPP-------DNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPF 170
                     ||       :.|.:||.||:.:.:.|:.:.|. .|||||...:.:|.|||:|:||:
Human   131 ---------PPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFA-NSPRPDLWVLERSMDFGRTYQPW 185

  Fly   171 QFYSS---QCQKFYGRPDRAKISKFNEQEARCINSQH-----DTGGAAQRFAFNTLEGRPSANDL 227
            ||::|   .|.:.:|.....:|::  :..|.|.....     :.|    ....:.:.|||.|.:.
Human   186 QFFASSKRDCLERFGPQTLERITR--DDAAICTTEYSRIVPLENG----EIVVSLVNGRPGAMNF 244

  Fly   228 DSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYD 292
            ..|.:|:::..||::|:.|.|            .|.....:.|....|
Human   245 SYSPLLREFTKATNVRLRFLR------------TNTLLGHLMGKALRD----------------- 280

  Fly   293 YNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATT 357

Human   281 ----------------------------------------------------------------- 280

  Fly   358 PPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGS 422
                 |.||.                       ..:|::.|.::||||.|:|||..|
Human   281 -----PTVTR-----------------------RYYYSIKDISIGGRCVCHGHADAC-------- 309

  Fly   423 GTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRA 487
                    |.:|...|                  ..:.|.|:|||.|..|:||.|.:..:||..|
Human   310 --------DAKDPTDP------------------FRLQCTCQHNTCGGTCDRCCPGFNQQPWKPA 348

  Fly   488 TDNDANECKMCQCNGHARRCRFNLEL------YKLSGRV-SGGVCYNCQHDTTGRYCHYCREGYY 545
            |.|.||||:.|.|.|||..|.::.|:      ..|.|.. .||||.:|||.|||..|..|..|:|
Human   349 TANSANECQSCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFY 413

  Fly   546 RDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIK 610
            |....|.:...||:||:|....:.| ||..|:|:|.|:...:|..|:.||.|:....|    |..
Human   414 RSPNHPLDSPHVCRRCNCESDFTDG-TCEDLTGRCYCRPNFSGERCDVCAEGFTGFPS----CYP 473

  Fly   611 VPTNANMIQAESAGGG----------GGGGTGDYKDGGGSQVEEMKKYCGKCKASP 656
            .|:::|..:.:....|          |..|....||          ...|:|...|
Human   474 TPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKD----------PRVGRCLCKP 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	62/262 (24%)
		EGF_Lam	<458..484	CDD:238012	10/25 (40%)
		EGF_Lam	498..555	CDD:238012	25/63 (40%)
		EGF_Lam	560..608	CDD:238012	16/47 (34%)
		NTR_netrin-1_like	661..791	CDD:239634
LAMA5	XP_006723859.1	Laminin_N	54..298	CDD:278484	68/389 (17%)
		EGF_Lam	299..347	CDD:238012	22/81 (27%)
		EGF_Lam	358..421	CDD:238012	25/62 (40%)
		EGF_Lam	428..470	CDD:238012	15/42 (36%)
		EGF_Lam	494..541	CDD:214543	7/36 (19%)
		EGF_Lam	540..583	CDD:238012
		Laminin_EGF	587..634	CDD:278482
		Laminin_EGF	632..679	CDD:278482
		EGF_Lam	676..718	CDD:238012
		EGF_Lam	775..827	CDD:238012
		EGF_Lam	828..>867	CDD:238012
		Laminin_EGF	1438..1486	CDD:278482
		Laminin_EGF	1528..1579	CDD:278482
		Laminin_EGF	1577..1625	CDD:278482
		Laminin_B	1693..1818	CDD:278481
		Laminin_EGF	1864..1913	CDD:278482
		Laminin_EGF	1913..1966	CDD:278482
		EGF_Lam	1968..2021	CDD:238012
		EGF_Lam	2023..2067	CDD:214543
		EGF_Lam	2069..2115	CDD:238012
		Laminin_EGF	2117..>2145	CDD:278482
		Laminin_I	2188..2450	CDD:283627
		TorS_sensor_domain	2287..2578	CDD:293930
		PspA_IM30	2435..2695	CDD:281941
		Laminin_II	2641..2762	CDD:283628
		LamG	2781..2908	CDD:214598
		LamG	2943..3095	CDD:238058
		LamG	3124..3267	CDD:238058
		LamG	3345..3502	CDD:238058
		LamG	3526..3676	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910