DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and LanA

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster

Alignment Length:	708	Identity:	157/708 - (22%)
Similarity:	244/708 - (34%)	Gaps:	276/708 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MGLLLPIILALAIGSSAAGISSNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCG--AQQPERYC 71
            :|.|| :|||::.            |..|     ..|.:.|.|.|..:.|::.||  ...||.||
  Fly     8 IGALL-VILAISY------------CQAE-----LTPPYFNLATGRKIYATATCGQDTDGPELYC 54

  Fly    72 ELLR--------DGNAGECRSCEQQRYGPAALTDLNNP------SNVTCWRSGAVNVPHDPDSAP 122
            :|:.        |.:..:.:.|:   |....:.:.|:|      .....|:|            |
  Fly    55 KLVGANTEHDHIDYSVIQGQVCD---YCDPTVPERNHPPENAIDGTEAWWQS------------P 104

  Fly   123 P-------DNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYS---SQC 177
            |       :.|.||::..:::.:.|:.:.. ..||||....:.||:|:|:||.|:|.:|   :.|
  Fly   105 PLSRGMKFNEVNLTINFEQEFHVAYLFIRM-GNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADC 168

  Fly   178 QKFYGRPDRAKISKFNEQEARCINSQH-----DTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWV 237
            :.::|:.....|::  :.:..|.....     :.|    ......|..|||:.:..:|.|||:|.
  Fly   169 ETYFGKDTYKPITR--DDDVICTTEYSKIVPLENG----EIPVMLLNERPSSTNYFNSTVLQEWT 227

  Fly   238 TATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSAD 302
            .||::|:         :||:.||.      :|
  Fly   228 RATNVRI---------RLLRTKNL------LG--------------------------------- 244

  Fly   303 AGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTP 367
                                ||      .||.:                         |.|.||.
  Fly   245 --------------------HL------MSVAR-------------------------QDPTVTR 258

  Fly   368 PGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDG 432
                                   ...|::.|.::||||.|||||..|
  Fly   259 -----------------------RYFYSIKDISIGGRCMCNGHADTC------------------ 282

  Fly   433 QDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKM 497
             |...|.:|              ...:.|.|:|:|.|.:|..|.|.:..:.|.:.|:.....|:.
  Fly   283 -DVKDPKSP--------------VRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEP 332

  Fly   498 CQCNGHARRCRFNLELYK------LSGRV-SGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHR 555
            |.|:||:..|:::.|:.:      :.|.. .||||.||||:|.|..|:.|:..|||...|..|..
  Fly   333 CNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNET 397

  Fly   556 KVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNANMIQA 620
            .||..|.|....|||. |...:|.|.|:......:|:.||.||....:    |.:...|.|
  Fly   398 DVCSPCQCDYFFSTGH-CEEETGNCECRAAFQPPSCDSCAYGYYGYPN----CRECECNLN---- 453

  Fly   621 ESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKAS-----PKKLNLN----KFCMEDY 669
                     ||..|                .|:|.     |.|:|..    |.|.|.|
  Fly   454 ---------GTNGY----------------HCEAESGQQCPCKINFAGAYCKQCAEGY 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	59/254 (23%)
		EGF_Lam	<458..484	CDD:238012	8/25 (32%)
		EGF_Lam	498..555	CDD:238012	24/63 (38%)
		EGF_Lam	560..608	CDD:238012	14/47 (30%)
		NTR_netrin-1_like	661..791	CDD:239634	4/13 (31%)
LanA	NP_476617.1	LamNT	18..271	CDD:214532	72/413 (17%)
		EGF_Lam	272..>314	CDD:238012	19/74 (26%)
		EGF_Lam	332..389	CDD:238012	21/56 (38%)
		EGF_Lam	402..443	CDD:238012	14/41 (34%)
		EGF_Lam	448..491	CDD:238012	14/68 (21%)
		Laminin_EGF	495..543	CDD:278482
		Laminin_EGF	541..589	CDD:278482
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445151
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940