DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and Megf8

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_609180.3	Gene:	Megf8 / 34099	FlyBaseID:	FBgn0031981	Length:	2892	Species:	Drosophila melanogaster

Alignment Length:	386	Identity:	93/386 - (24%)
Similarity:	135/386 - (34%)	Gaps:	107/386 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 ISQHYAVSDFAVGGRCKC-NGHASE---CVATVSSG--SGTALS-DQ---DDGQDEDTPSAPSLA 444
            :|:.....|.|||.:|.| .|:..|   |:...|.|  .|..:| ||   |.|......|...|.
  Fly  2237 VSEQCIDLDTAVGYKCVCAQGYREEQGACLPVCSQGCVRGNCVSPDQCQCDFGYVGANCSIQCLC 2301

  Fly   445 NHFGRST-QMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMC--QCNGHARR 506
            |  |.|. :.|::|.:...|.:||.|.:||:|:|.:...|      .:.:.|:.|  .|:||:..
  Fly  2302 N--GHSNCESSSRLDICLKCHNNTMGEQCEKCQPLFVGNP------REGHACQPCLDYCHGHSDV 2358

  Fly   507 C-------------RFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVC 558
            |             |..||.....|......|..|.:.|.|..|..|..||:|.:   .:..|.|
  Fly  2359 CVAYDADPAVFNMTRSELERILQEGPAYNATCLRCGNHTAGDRCDSCLTGYFRGS---EDLHKEC 2420

  Fly   559 KRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNANMIQAESA 623
            :.|.||   ..|..|          :.|||..|| ||...:..    |.|             :|
  Fly  2421 RPCQCH---GHGNIC----------DPVTGEKCN-CANNTESD----ATC-------------TA 2454

  Fly   624 GGGGGGG---------------TGDYKDGGG--SQVEEMKKYC------GKCKASPKKLNLN--- 662
            |||....               .|:..||..  .|:....:.|      .:||:.|..|...
  Fly  2455 GGGKNSAQLCWMVQCSKCRDSYAGNPTDGHQCYKQITVESRMCFDAKPIEECKSKPAALKPGQTV 2519

  Fly   663 ------KFCMEDYAILAKVIGHD----RASQDISTEKFSIERQNEIYKYEINIQTIFKRNP 713
                  :|...|..|:..|...:    .:.||   :.|.:|.......:||.:...:...|
  Fly  2520 FFVIQPRFMNVDIRIIIDVTQGELDVFMSPQD---DSFIVETNETTGYHEIFLDNRYNWGP 2577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532
		EGF_Lam	<458..484	CDD:238012	8/25 (32%)
		EGF_Lam	498..555	CDD:238012	18/71 (25%)
		EGF_Lam	560..608	CDD:238012	13/47 (28%)
		NTR_netrin-1_like	661..791	CDD:239634	11/66 (17%)
Megf8	NP_609180.3	CUB	33..141	CDD:238001
		KELCH repeat	228..268	CDD:276965
		Kelch_4	369..414	CDD:290154
		KELCH repeat	370..420	CDD:276965
		KELCH repeat	425..476	CDD:276965
		KELCH repeat	480..540	CDD:276965
		EGF_3	1186..1220	CDD:289699
		EGF_Lam	1257..1302	CDD:238012
		EGF_Lam	1304..1354	CDD:238012
		CUB	1372..1484	CDD:238001
		Kelch_4	1584..1628	CDD:290154
		KELCH repeat	1585..1638	CDD:276965
		KELCH repeat	1642..1685	CDD:276965
		Kelch_3	1656..1710	CDD:290151
		KELCH repeat	1760..1813	CDD:276965
		Kelch_4	1760..1802	CDD:290154
		KELCH repeat	1817..1867	CDD:276965
		EGF_Lam	2299..2346	CDD:238012	15/54 (28%)
		EGF_Lam	2422..2487	CDD:238012	21/95 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445157
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10574
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030