DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and Lamc3

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001101300.1	Gene:	Lamc3 / 311862	RGDID:	1309399	Length:	1580	Species:	Rattus norvegicus

Alignment Length:	758	Identity:	225/758 - (29%)
Similarity:	311/758 - (41%)	Gaps:	259/758 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IILALAIGSSAAGISSNDPCY-FEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGN 78
            :::..|..::.||:.|   || ..|:.::|||.|.|||:|...:||..|| |.||.:|..:....
  Rat    18 LVMLKAHCATGAGMGS---CYDGAGRAQRCLPEFENAAFGRRAEASHTCG-QPPEDFCPHVGAPG 78

  Fly    79 AG-ECRSCE----QQRYGPAALTDLNNPSNVTCWRSG--AVNVPHDPDSAPPDNVTLTLSLGKKY 136
            || :|:.|:    ::|:..:.|||.::|.:.|.|:|.  |..|.:      |.:|.|||.|||.|
  Rat    79 AGPQCQRCDDADPRRRHDASYLTDFHSPDDSTWWQSPSMAFGVQY------PTSVNLTLHLGKAY 137

  Fly   137 ELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISK-FNEQEARCI 200
            |:||:.|.|  .:.||:|.||:|.:..|..|:|:|:||:.|||.||.|:...:.. .:|:.|.|.
  Rat   138 EITYVRLKF--HTSRPESFAIYKRTHTGGPWEPYQYYSASCQKTYGHPEGHYLRPGEDERVAFCT 200

  Fly   201 NSQHD----TGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNA 261
            :...|    .||   ..||:||||||||.:.:.|.|||:|||:||:.:...||
  Rat   201 SEFSDISPLNGG---NVAFSTLEGRPSAYNFEESPVLQEWVTSTDLLISLDRL------------ 250

  Fly   262 NAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDY 326
            |.|.|                                       |.:::|:
  Rat   251 NTFGD---------------------------------------DIFKDPR-------------- 262

  Fly   327 ASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPIS 391
                  |::                                                       |
  Rat   263 ------VLQ-------------------------------------------------------S 266

  Fly   392 QHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAK 456
            .:||||||:||||||||||||.|            ...:.||
  Rat   267 YYYAVSDFSVGGRCKCNGHASAC------------GPNEAGQ----------------------- 296

  Fly   457 LTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVS 521
              :.|.|:|||.|.:||||.||:.||||.|.|..|||||..|.|:||:..|.|:.|||:.:|.
  Rat   297 --LACHCQHNTTGVDCERCLPFFQDRPWARGTAEDANECLPCNCSGHSEECTFDRELYRSTGH-- 357

  Fly   522 GGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGV 586
            ||.|..|:..|.|.:|.:|.:.|||...|.|     |:.|||||.||....|:: ||.||||..|
  Rat   358 GGHCQRCRDHTAGPHCEHCEKNYYRWDPKTP-----CQPCDCHPAGSLSLQCDN-SGTCPCKLTV 416

  Fly   587 TGLTCNRCARGYQQ-TRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMK-KYC 649
            ||..|:||..|:.. :.....||             :....|..||.|.:.|.....|.:: ..|
  Rat   417 TGWKCDRCLPGFHSLSEGGCRPC-------------TCNVAGSLGTCDPRSGNCPCKENVEGGLC 468

  Fly   650 GKCKASPKKLNLNK---------FCMEDYAILAKVIG----HDRAS--------QDISTEKFSIE 693
            .:|:  |...||..         ||.....:.|...|    |.|:.        |..|||
  Rat   469 DRCR--PGTFNLQPHNPAGCSSCFCYGHSKVCAPASGFQEHHIRSDFRHGADGWQARSTE----- 526

  Fly   694 RQNEIYKYEINIQTIFKRNPMSGTTSS-LLG-RGNMMLLVPRK 734
                           ....|:..:.|. ||| ||...|..|.|
  Rat   527 ---------------VSERPLQWSQSGILLGLRGGEELSAPEK 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	90/235 (38%)
		EGF_Lam	<458..484	CDD:238012	14/25 (56%)
		EGF_Lam	498..555	CDD:238012	23/56 (41%)
		EGF_Lam	560..608	CDD:238012	21/48 (44%)
		NTR_netrin-1_like	661..791	CDD:239634	21/97 (22%)
Lamc3	NP_001101300.1	Laminin_N	53..278	CDD:278484	96/362 (27%)
		EGF_Lam	279..326	CDD:238012	29/83 (35%)
		Laminin_EGF	336..392	CDD:278482	24/62 (39%)
		Laminin_EGF	392..439	CDD:278482	21/47 (45%)
		Laminin_EGF	439..486	CDD:278482	12/61 (20%)
		Laminin_B	550..671	CDD:278481	2/5 (40%)
		EGF_Lam	718..765	CDD:238012
		EGF_Lam	766..814	CDD:238012
		EGF_Lam	821..864	CDD:238012
		Laminin_EGF	878..925	CDD:278482
		Laminin_EGF	928..976	CDD:278482
		Laminin_EGF	976..>1013	CDD:278482
		Laminin_I	1183..1464	CDD:283627
		ATP-synt_B	<1211..1308	CDD:304375
		KASH_CCD	1387..1574	CDD:291334
		SPEC	<1407..1572	CDD:295325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910