DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and Ntng2

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_006233862.1	Gene:	Ntng2 / 311836	RGDID:	1307089	Length:	635	Species:	Rattus norvegicus

Alignment Length:	706	Identity:	135/706 - (19%)
Similarity:	204/706 - (28%)	Gaps:	352/706 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AGISSNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNAGECRSCEQQRY 90
            :||:..||     ..|.|       ::.||...|:.|.|..|:                   ..:
  Rat    57 SGITCGDP-----PERFC-------SHENPYLCSNECDASNPD-------------------LAH 90

  Fly    91 GPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELT-YISLSFCPRSPRPDS 154
            .|..:.|..:....|.|:|  |.....|.   |....:|||..|..||| .:.::|  ...||..
  Rat    91 PPRLMFDREDEGLATYWQS--VTWSRYPS---PLEANITLSWNKSVELTDDVVMTF--EYGRPTV 148

  Fly   155 LAIFKSSDFGQTWQPFQFYSSQCQKFYG---------RPDRAKISKFNEQEARCINS---QHDTG 207
            :.:.||.|.|:||||:|||:..|.:.:|         .|..|......|:.:|...|   :|...
  Rat   149 MVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSPSSAHRVLCTEEYSRWAGSKKEKHVRF 213

  Fly   208 GAAQRFAFNTLEGRPSANDLD-------SSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFS 265
            ....|||   :...|...::|       |:..|:::.|.||:|:   || |.|.|
  Rat   214 EVRDRFA---IFAGPDLRNMDNLYTRMESAKGLKEFFTFTDLRM---RL-LRPAL---------- 261

  Fly   266 DEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDG 330
                                                                            |
  Rat   262 ----------------------------------------------------------------G 262

  Fly   331 ESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYA 395
            .:.|:|:..:|                                                  ..||
  Rat   263 GTYVQRENLYK--------------------------------------------------YFYA 277

  Fly   396 VSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMT 460
            :|:..|.||||||.||:.|  ||..||                                    :.
  Rat   278 ISNIEVIGRCKCNLHANLC--TVREGS------------------------------------LQ 304

  Fly   461 CACKHNTAGPECERCKPFYFDRPW----------------------------------------- 484
            |.|:|||.||:|.:||..:..|.|
  Rat   305 CECEHNTTGPDCGKCKKNFRTRAWRAGSYLPLPHGSPNACAAAGSAFGSTSRSRKIPAPKAPMAT 369

  Fly   485 ---------------------------------------------------------------GR 486
                                                                           .:
  Rat   370 EATRRGPVTSIPSTSTIQVPTAPSTPHPTGQTKPTTVAPLGDSSFWPQVSSSAEAVTIPVAIPSQ 434

  Fly   487 ATDN-------------DANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCH 538
            |.|:             ...|.:.|:|.||:.||.: ::...:.      .|.:|:|:|.|::|.
  Rat   435 AKDSTLFQLKPRSPQVIPIEEFQDCECYGHSNRCSY-IDFLNVV------TCVSCKHNTRGQHCQ 492

  Fly   539 YCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRC 594
            :||.||||:.:...:...||..|:|:.:||....||. :|.|.|:||..|..|:.|
  Rat   493 HCRLGYYRNGSAELDDENVCIECNCNQIGSVHDRCNE-TGFCECREGAVGPKCDDC 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	61/243 (25%)
		EGF_Lam	<458..484	CDD:238012	11/25 (44%)
		EGF_Lam	498..555	CDD:238012	18/56 (32%)
		EGF_Lam	560..608	CDD:238012	14/35 (40%)
		NTR_netrin-1_like	661..791	CDD:239634
Ntng2	XP_006233862.1	Laminin_N	60..285	CDD:278484	71/393 (18%)
		EGF_Lam	286..332	CDD:238012	24/83 (29%)
		EGF_Lam	459..507	CDD:238012	18/54 (33%)
		Laminin_EGF	515..562	CDD:278482	14/34 (41%)
		EGF_2	562..592	CDD:285248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810