Protein Alignment NetB and Lama2

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: XP_063120697.1
• Gene: Lama2 / 309368
• RGDID: 1308889
• Length: 3225
• Species: Rattus norvegicus
• Alignment Length: 712
• Identity: 161/712 - (22%)
• Similarity: 254/712 - (35%)
• Gaps: 239/712 - (33%)

  Fly    10 GLLLPIILALAIGSSAAGISS--NDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCE 72
            |:||.::|.:..||.......  ..|.:   :.|...|:.:|.|....:..::.||.:.||.||:
  Rat     6 GILLLLLLGILEGSQTQRPQQRRQSPAH---QQRGLFPAVLNLASNALITTNATCGEKGPEMYCK 67

  Fly    73 LL-----RDGNAGECRSCEQQRYGPAALTDLNN--PSNVTCWRSGAVNVPHDPDSAPPDNVTLTL 130
            |:     :.....:||.|.|....|.....:.|  ....|.|:|     |...:......||:||
  Rat    68 LVEHVPGQPVRNPQCRICNQNSSHPYQRHPITNAIDGKNTWWQS-----PSIKNGVEYHYVTITL 127

  Fly   131 SLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYS---SQCQKFY------GRPDR 186
            .|.:.:::.|:.:. ...||||.:..:.:|.| .:.::|:|:::   ::|...|      |.|..
  Rat   128 DLQQVFQIAYVIVK-AANSPRPGNWILERSLD-DEEYKPWQYHAVTDTECLTLYNIYPRTGPPSY 190

  Fly   187 AKISKFNEQEARCINSQH-----DTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVF 246
            ||     :.|..|.:...     :.|    ....:.:.|||||:|....|:  ::.:|..||:.|
  Rat   191 AK-----DDEVICTSFYSKIHPLENG----EIHISLINGRPSADDPSPELL--EFTSARYIRLRF 244

  Fly   247 HRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEP 311
            .|         ::..|                 |||.:...:|                     |
  Rat   245 QR---------IRTLN-----------------ADLMMFAHKD---------------------P 262

  Fly   312 KKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPST 376
            :   |:|             .:|.|:
  Rat   263 R---EID-------------PIVTRR--------------------------------------- 272

  Fly   377 AAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAP 441
                           .:|:|.|.:|||.|.|.|||..|                       |..|
  Rat   273 ---------------YYYSVKDISVGGMCICYGHARAC-----------------------PLDP 299

  Fly   442 SLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARR 506
                    :|..|     .|.|:|||.|..|:||.|.:..:||...|.....||:.|.|:|.|..
  Rat   300 --------ATNKS-----RCECEHNTCGESCDRCCPGFHQKPWRAGTFLTKTECEACNCHGKAEE 351

  Fly   507 CRF-------NLELYKLSGR-VSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDC 563
            |.:       ||.| .:.|: :.||||.||.|:|.|..|..|.:|::|.....|::.:.|:.|.|
  Rat   352 CYYDETVASRNLSL-NIHGKYIGGGVCINCTHNTAGINCETCIDGFFRPKGVSPSYPRPCQPCHC 415

  Fly   564 HPVGSTGKTC----NHL-----SGQCPCKEGVTGLTCNRCARGYQ------------QTRSHVAP 607
            .|.||..:.|    .|.     .|.|.||.|..|:.|:||.|||:            ...::..|
  Rat   416 DPAGSLSEVCIKDEKHTRRGLKPGSCYCKPGFGGMNCDRCVRGYRGYPDCQPCNCSGLGSTNQDP 480

  Fly   608 CIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASPKKLNLNKFCMEDY 669
            ||...:....::.|..        ...|.|..:..||.:|.|.:|..|    .::..|...|
  Rat   481 CIGPCSCKENVEGEDC--------SHCKFGFFNLQEENQKGCEECFCS----GVSDRCQSSY 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	56/244 (23%)
		EGF_Lam	<458..484	CDD:238012	10/25 (40%)
		EGF_Lam	498..555	CDD:238012	23/64 (36%)
		EGF_Lam	560..608	CDD:238012	19/68 (28%)
		NTR_netrin-1_like	661..791	CDD:239634	2/9 (22%)
Lama2	XP_063120697.1	None