DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetB and ntn1a

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_571104.1	Gene:	ntn1a / 30227	ZFINID:	ZDB-GENE-990415-169	Length:	603	Species:	Danio rerio

Alignment Length:	780	Identity:	322/780 - (41%)
Similarity:	416/780 - (53%)	Gaps:	226/780 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AAGISSNDPCYFE-GKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNA--GECRSCE 86
            ||..|..||||.| |.||:|:|.|||||:|..|:|||.|| :.|.|||.:...|:.  ..|.:|:
Zfish    31 AAQTSPPDPCYDENGHPRRCIPDFVNAAFGKEVRASSTCG-KTPSRYCVVTEKGDERHRNCHTCD 94

  Fly    87 ----QQRYGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYISLSFCP 147
                ::.:.||.|||||||.|:|||:|       |.....|.|||||||||||:|:||:||.||
Zfish    95 ASDPKKNHPPAYLTDLNNPHNLTCWQS-------DNYLQYPQNVTLTLSLGKKFEVTYVSLQFC- 151

  Fly   148 RSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHD----TGG 208
             ||||:|:|||||.|:|::|.|||:||:||:|.|.:|.:|.|:|.|||||.|.:|..|    :||
Zfish   152 -SPRPESMAIFKSMDYGKSWVPFQYYSTQCRKMYNKPSKATITKQNEQEAICTDSHTDMHPLSGG 215

  Fly   209 AAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSRE 273
            .   .||:||:|||||:|.|:|.|||||||||||:|.|.||            :.|.||
Zfish   216 L---IAFSTLDGRPSAHDFDNSPVLQDWVTATDIKVTFSRL------------HTFGDE------ 259

  Fly   274 EDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQG 338
              .:||::|..|
Zfish   260 --NEDDSELARD----------------------------------------------------- 269

  Fly   339 KHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGG 403
                                                                |..|||||..|||
Zfish   270 ----------------------------------------------------SYFYAVSDLQVGG 282

  Fly   404 RCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTA 468
            |||||||||.||           .|:|.                          .:.|.||||||
Zfish   283 RCKCNGHASRCV-----------KDRDG--------------------------NLVCECKHNTA 310

  Fly   469 GPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTT 533
            ||||:|||||::||||.|||..:||||..|.||.||||||||:||||||||.|||||.||:|:|.
Zfish   311 GPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTA 375

  Fly   534 GRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGY 598
            ||:||||:||||||.:||.:|||.||.|||||||:.|||||..:||||||:||||:||||||.||
Zfish   376 GRHCHYCKEGYYRDMSKPISHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCANGY 440

  Fly   599 QQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASPKKLNLNK 663
            ||:||.:|||||:|.......|.|.                .:..:.:.|| |......|:|:.|
Zfish   441 QQSRSPIAPCIKIPIAPPTTTASST----------------EEPSDCESYC-KASKGKLKINMKK 488

  Fly   664 FCMEDYAILAKVIGHDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSLLGRGNMM 728
            :|.:|||:...::..|:|              .|.:|:.:||.:::|:.      .|.:.||:..
Zfish   489 YCKKDYAVQVHILKADKA--------------GEWWKFTVNIISVYKQG------ESRIRRGDQF 533

  Fly   729 LLVPRKSIECQCPKIKLNKSYLILGRDSEAAPGY--LAIGPSSVVLEWKDEWSLRMKRFQRRARK 791
            |.|..|.:.|:|||||..|.||:||.| |.:||.  :.....|:|::|:|.|:.|:::||:|.:|
Zfish   534 LWVRAKDVACKCPKIKSGKKYLLLGND-EDSPGQSGMVADKGSLVIQWRDTWARRLRKFQQREKK 597

Fly 792 791
Zfish 598 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	122/234 (52%)
		EGF_Lam	<458..484	CDD:238012	18/25 (72%)
		EGF_Lam	498..555	CDD:238012	42/56 (75%)
		EGF_Lam	560..608	CDD:238012	35/47 (74%)
		NTR_netrin-1_like	661..791	CDD:239634	42/131 (32%)
ntn1a	NP_571104.1	LamNT	45..282	CDD:214532	135/374 (36%)
		EGF_Lam	283..328	CDD:238012	33/81 (41%)
		Laminin_EGF	340..393	CDD:278482	40/52 (77%)
		EGF_Lam	402..450	CDD:238012	35/47 (74%)
		NTR_netrin-1_like	486..600	CDD:239634	43/133 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580916
Domainoid	1	1.000	101	1.000	Domainoid score	I6881
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21008
Inparanoid	1	1.050	631	1.000	Inparanoid score	I821
OMA	1	1.010	-	-		QHG48023
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	1	1.000	-	-		FOG0003523
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104609
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2886
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940