DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and ntn1b

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_571073.1	Gene:	ntn1b / 30192	ZFINID:	ZDB-GENE-990415-168	Length:	602	Species:	Danio rerio

Alignment Length:	785	Identity:	317/785 - (40%)
Similarity:	414/785 - (52%)	Gaps:	230/785 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AAGISSNDPCYFE-GKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDG--NAGECRSCE 86
            ||..|..||||.| |.||:|:|.|||:|:|..|:.||.||: .|.|.|.:...|  .:.:|..|:
Zfish    31 AAQSSPPDPCYDENGNPRRCIPDFVNSAFGKDVRVSSTCGS-PPSRCCRVTEKGEERSRDCNICD 94

  Fly    87 ----QQRYGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYISLSFCP 147
                ::.:.||.|||||||.|:|||:|       :.....|.|||||||||||:|:||:||.||
Zfish    95 ATDPKKTHPPAYLTDLNNPHNLTCWQS-------ENYVQYPQNVTLTLSLGKKFEVTYVSLQFC- 151

  Fly   148 RSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHD----TGG 208
             ||||:|:|||||.|:|:||.||||||:||:|.|.:|.:|.|:|.|||||.|.:|..|    |||
Zfish   152 -SPRPESMAIFKSMDYGKTWVPFQFYSTQCKKMYNKPSKAAITKQNEQEAICTDSHTDMQPLTGG 215

  Fly   209 AAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSRE 273
            .   .||:||:|||||:|.|:|.|||||||||||:|.|:||            :.|.||
Zfish   216 L---IAFSTLDGRPSAHDFDNSPVLQDWVTATDIKVTFNRL------------HTFGDE------ 259

  Fly   274 EDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQG 338
              .:||::|..|
Zfish   260 --NEDDSELARD----------------------------------------------------- 269

  Fly   339 KHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGG 403
                                                                |..|||||..|||
Zfish   270 ----------------------------------------------------SYFYAVSDLQVGG 282

  Fly   404 RCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTA 468
            |||||||||:||           .|::.                          .:.|.||||||
Zfish   283 RCKCNGHASKCV-----------KDREG--------------------------NLVCECKHNTA 310

  Fly   469 GPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQHDTT 533
            ||||:|||||::||||.|||..:||||..|.||.||||||||:||||||||.|||||.||:|:|.
Zfish   311 GPECDRCKPFHYDRPWQRATAREANECVACHCNLHARRCRFNMELYKLSGRRSGGVCLNCRHNTA 375

  Fly   534 GRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGY 598
            ||:||||:||||||.:|..:||:.||.|||||||:.|||||..:||||||:||||:||||||:||
Zfish   376 GRHCHYCKEGYYRDMSKAISHRRACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGY 440

  Fly   599 QQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASPKKLNLNK 663
            ||:||.:|||||:|..|              .|..|....|.  .:...:| |......|:.:.|
Zfish   441 QQSRSPIAPCIKIPVAA--------------PTSSYSSPDGP--TDCDSHC-KAPKGKMKVTMKK 488

  Fly   664 FCMEDYAILAKVIGHDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSLLGRGNMM 728
            :|.:|:|:...|:..|:|              .|.:|:.|||.:::|:.      ...:.||:.:
Zfish   489 YCKKDFAVQVHVLKGDKA--------------GEWWKFTINIISVYKQG------GHRIRRGDQL 533

  Fly   729 LLVPRKSIECQCPKIKLNKSYLILG----RDSEAAPGYLAIGPSSVVLEWKDEWSLRMKRFQRRA 789
            |.|..|.:.|:|||||..:.||::|    .||....|.:| ...|:::.|||.|:.|:::||:|.
Zfish   534 LWVRAKDVACKCPKIKPGRKYLLMGSDEEEDSRGQSGVVA-DRGSLLIPWKDLWARRLRKFQQRD 597

  Fly   790 R--KC 792
            :  ||
Zfish   598 KRGKC 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	121/234 (52%)
		EGF_Lam	<458..484	CDD:238012	18/25 (72%)
		EGF_Lam	498..555	CDD:238012	41/56 (73%)
		EGF_Lam	560..608	CDD:238012	35/47 (74%)
		NTR_netrin-1_like	661..791	CDD:239634	40/135 (30%)
ntn1b	NP_571073.1	LamNT	45..282	CDD:214532	134/374 (36%)
		EGF_Lam	283..328	CDD:238012	32/81 (40%)
		Laminin_EGF	340..389	CDD:278482	38/48 (79%)
		Laminin_EGF	403..>440	CDD:278482	28/36 (78%)
		NTR_netrin-1_like	486..602	CDD:239634	40/136 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580915
Domainoid	1	1.000	101	1.000	Domainoid score	I6881
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	631	1.000	Inparanoid score	I821
OMA	1	1.010	-	-		QHG48023
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	1	1.000	-	-		FOG0003523
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104609
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2886
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.800