DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and Ntn4

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001100250.1	Gene:	Ntn4 / 299737	RGDID:	1565947	Length:	630	Species:	Rattus norvegicus

Alignment Length:	835	Identity:	203/835 - (24%)
Similarity:	309/835 - (37%)	Gaps:	265/835 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MGLLLPIILALAIGSSAAGISS----NDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPER 69
            ||....::|.....:.|||.:.    |..|     .:.|.|...|.|.|..:||.:.||....|.
  Rat     1 MGSCARLLLLWGCSAVAAGFNGVSGVNSRC-----EKACNPRMGNLALGRKLQADTTCGQNATEL 60

  Fly    70 YCELLRDGNAG------ECRSC----EQQRYGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPD 124
            :|  ....||.      :|..|    ....:.|:|:.|.:.....|.|:| |.:|..:
  Rat    61 FC--FYSENADLTCRQPKCDKCNGAHSHLAHPPSAMADSSFRFPRTWWQS-AEDVHRE------- 115

  Fly   125 NVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKI 189
              .:.|.|..::..|::.:.|  :||||.::.:.:|.|||:||:|::::::.|...:|..|.. :
  Rat   116 --KIQLDLEAEFYFTHLIMVF--KSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDV-V 175

  Fly   190 SKFNEQEARCINSQHDTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQ 254
            .|.....:|..|....|||                                  .|:|..|. ||
  Rat   176 KKGAICTSRYSNPFPCTGG----------------------------------EVIFRALS-PP- 204

  Fly   255 LLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDD 319
                                                  |::::..||        :.::.|::.:
  Rat   205 --------------------------------------YDIENPYSA--------KVQEQLKITN 223

  Fly   320 DHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAAS 384
            ..:.|         :|||                  :.|.|:......|...|
  Rat   224 LRVRL---------LKRQ------------------SCPCQRNDLNAKPHHFT------------ 249

  Fly   385 AVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGR 449
                    |||:.||.|.|.|.|||||.:|:..            :..:....|.|..:.:  |:
  Rat   250 --------HYAIYDFIVKGSCFCNGHADQCLPV------------EGFRPVKAPGAFHVVH--GK 292

  Fly   450 STQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDA--NECKMCQCNGHARRCRFNLE 512
                       |.|||||||..|:.|.|.|.||||..|.....  |||:.|:|||||..|.|::.
  Rat   293 -----------CMCKHNTAGSHCQHCAPLYNDRPWEAADGRTGAPNECRTCKCNGHADTCHFDIN 346

  Fly   513 LYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVG------STGK 571
            :::.||..|||||.||||:|.|::|..|:.|:|||..:|.:....||.|.|||||      |:..
  Rat   347 VWEASGNRSGGVCNNCQHNTEGQHCQRCKPGFYRDLRRPFSAPDACKACSCHPVGSAILPFSSVT 411

  Fly   572 TCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSH-VAPCIKVPTNANMIQAESAGGGGGGGTGD-- 633
            .|:..:|.||||.||.|..|:||..||.....: ..||             ...|.....|||
  Rat   412 FCDPSNGDCPCKPGVAGPHCDRCMVGYWGFGDYGCRPC-------------DCAGSCDPLTGDCI 463

  Fly   634 -------------------YKDGGGSQVEEMK-----KYCGKCKASPKKL-NLNKFCMEDYAILA 673
                               .|...|.:.|:.:     ::.|||:...:.| |...||...|:.:.
  Rat   464 SSNADVDWYHEVPAFHSLHNKSEPGWEWEDEQGFSALRHSGKCECKEQVLGNPKAFCGMKYSYVL 528

  Fly   674 KV---IGHDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSLLGRGNMMLLVPRK- 734
            |:   ..||:.|.                 .|:|::.   :..:..|...:| ||. ..|.|..
  Rat   529 KIKILSAHDKGSH-----------------AEVNVKI---KKVLQATKLKIL-RGK-RTLYPESW 571

  Fly   735 -SIECQCPKIKLNKSYLILGRDSEAAPGYLAIGPSSVVLEWKDEWSLRMKRFQRR 788
             :..|.||.:.....||:.|.: :...|.|.:...|.|..||.....|:....:|
  Rat   572 TNRGCTCPILNPGLEYLVAGYE-DVRTGRLIVNMKSFVQPWKPALGRRVMHILKR 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	52/233 (22%)
		EGF_Lam	<458..484	CDD:238012	14/25 (56%)
		EGF_Lam	498..555	CDD:238012	28/56 (50%)
		EGF_Lam	560..608	CDD:238012	21/54 (39%)
		NTR_netrin-1_like	661..791	CDD:239634	29/133 (22%)
Ntn4	NP_001100250.1	Laminin_N	43..260	CDD:278484	66/360 (18%)
		EGF_Lam	261..320	CDD:238012	26/83 (31%)
		Laminin_EGF	332..392	CDD:278482	28/59 (47%)
		Laminin_EGF	395..449	CDD:278482	21/53 (40%)
		NTR_netrin-4_like	517..626	CDD:239633	29/132 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910