DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and lamc1

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_775384.1	Gene:	lamc1 / 286832	ZFINID:	ZDB-GENE-021226-3	Length:	1593	Species:	Danio rerio

Alignment Length:	705	Identity:	211/705 - (29%)
Similarity:	293/705 - (41%)	Gaps:	235/705 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SAAGISSNDPCYFE-GKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDGNAGECRSCE- 86
            :|....:.|.|..| .:|::|:|.|||||:...|.|::.||: .||.:|  ::.|..|..:||.
Zfish    14 AACSHGAMDECIDEDDRPQRCMPEFVNAAFNATVVATNTCGS-PPEEFC--VQTGVTGVTKSCHI 75

  Fly    87 ------QQRYGPAALTDLNNPSNVTCWRSGAV--NVPHDPDSAPPDNVTLTLSLGKKYELTYISL 143
                  :..:|...|||.|.|...|.|:|..:  .:.:      |:::.|||.|||.:::||:.|
Zfish    76 CNAADPRLHHGAVYLTDYNQPVQPTWWQSQTMLAGIQY------PNSINLTLHLGKSFDITYVRL 134

  Fly   144 SFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKI-SKFNEQEARCINSQHDT- 206
            .|  .:.||:|.||:|.|.....|.|:|:||..|:|.|.:.:|..| :..:||:|.|.:...|.
Zfish   135 KF--HTSRPESFAIYKRSSEDGPWTPYQYYSGSCEKTYSKNNRGFIRTGEDEQQALCTDEFSDIS 197

  Fly   207 ---GGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEM 268
               ||   ..||:||||||||.:.|:|.|||||||||||||..:||            |.|.||:
Zfish   198 PLYGG---NVAFSTLEGRPSAYNFDNSPVLQDWVTATDIRVTLNRL------------NTFGDEV 247

  Fly   269 GGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESV 333
                                                   :.:||                    |
Zfish   248 ---------------------------------------FNDPK--------------------V 253

  Fly   334 VKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSD 398
            :|                                                       |.:||:||
Zfish   254 LK-------------------------------------------------------SYYYAISD 263

  Fly   399 FAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCAC 463
            |||||||||||||||||                            .|.:.:         :.|.|
Zfish   264 FAVGGRCKCNGHASECV----------------------------KNEYSK---------LVCNC 291

  Fly   464 KHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNC 528
            ||||.|.:|..|||||.||||.|||..:.|||..|.|||.:..|.|:.|||:.:|.  ||.|.||
Zfish   292 KHNTEGADCNVCKPFYNDRPWRRATAENPNECLPCNCNGKSAECYFDPELYRATGH--GGHCRNC 354

  Fly   529 QHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNR 593
            ..:|.|..|..|...|||:|:     .:.|..|.|:||||....|:: :|:|.||.||.|..|:|
Zfish   355 ADNTDGPKCERCLANYYREAS-----GQRCLSCGCNPVGSLSTQCDN-TGRCSCKPGVMGDKCDR 413

  Fly   594 CARGYQQ-TRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKY-CGKCKASP 656
            |..||.. :.:...||             |....|.....|.:.|.....|.:..: |.:||..
Zfish   414 CQPGYHSLSEAGCRPC-------------SCNPAGSTQECDVQTGRCQCKENVDGFNCDRCKLG- 464

  Fly   657 KKLNLNK---------FCMEDYAILAKVIGHDRASQDISTEKF--SIERQNEIYK 700
             ..||:.         ||.:...:.....|:       |..|.  :.:|.:|.:|
Zfish   465 -YFNLDPQNPQGCTPCFCFQHSTVCESADGY-------SVHKITSTFDRDDEGWK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	91/238 (38%)
		EGF_Lam	<458..484	CDD:238012	15/25 (60%)
		EGF_Lam	498..555	CDD:238012	23/56 (41%)
		EGF_Lam	560..608	CDD:238012	19/48 (40%)
		NTR_netrin-1_like	661..791	CDD:239634	9/51 (18%)
lamc1	NP_775384.1	LamNT	30..268	CDD:214532	106/377 (28%)
		EGF_Lam	269..314	CDD:238012	30/81 (37%)
		Laminin_EGF	326..379	CDD:278482	23/59 (39%)
		Laminin_EGF	382..429	CDD:278482	19/47 (40%)
		Laminin_EGF	429..476	CDD:278482	11/61 (18%)
		Laminin_B	537..662	CDD:295357
		EGF_Lam	707..749	CDD:238012
		Laminin_EGF	812..856	CDD:278482
		EGF_Lam	867..917	CDD:238012
		EGF_Lam	919..964	CDD:214543
		Laminin_EGF	967..1013	CDD:278482
		Domain II and I. /evidence=ECO:0000250	1014..1593
		SPEC	1033..1233	CDD:295325
		Taxilin	1035..1308	CDD:286771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.870