DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and LAMA1

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_005550.2	Gene:	LAMA1 / 284217	HGNCID:	6481	Length:	3075	Species:	Homo sapiens

Alignment Length:	710	Identity:	167/710 - (23%)
Similarity:	248/710 - (34%)	Gaps:	258/710 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RMGLLLPIILALAIGSSAAGISSNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCE 72
            |.|:||.::|.:|.               :.:.|...|:.:|.|....:..::.||.:.||.:|:
Human     2 RGGVLLVLLLCVAA---------------QCRQRGLFPAILNLASNAHISTNATCGEKGPEMFCK 51

  Fly    73 LL-----RDGNAGECRSCEQQRYGPA-------ALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDN 125
            |:     |.....:||.|:.....|.       |:...||     .|:|     |...:......
Human    52 LVEHVPGRPVRNPQCRICDGNSANPRERHPISHAIDGTNN-----WWQS-----PSIQNGREYHW 106

  Fly   126 VTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYS---SQCQKFYG-RPDR 186
            ||:||.|.:.:::.|:.:. ...:|||.:..:.:|.| |.|:.|:|:|:   |:|...|. .|.|
Human   107 VTITLDLRQVFQVAYVIIK-AANAPRPGNWILERSLD-GTTFSPWQYYAVSDSECLSRYNITPRR 169

  Fly   187 AKISKFNEQEARC-------INSQHDTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRV 244
            ...:...:.|..|       :..:|.      ....:.:.|||||:||...|:  ::.:|..||:
Human   170 GPPTYRADDEVICTSYYSRLVPLEHG------EIHTSLINGRPSADDLSPKLL--EFTSARYIRL 226

  Fly   245 VFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYE 309
                     :|.:::..||  |.|..|                                    :.
Human   227 ---------RLQRIRTLNA--DLMTLS------------------------------------HR 244

  Fly   310 EPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPP 374
            |||   |||             .:|.|:
Human   245 EPK---ELD-------------PIVTRR------------------------------------- 256

  Fly   375 STAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPS 439
                             .:|::.|.:|||.|.|.||||.|                 ..||.|..
Human   257 -----------------YYYSIKDISVGGMCICYGHASSC-----------------PWDETTKK 287

  Fly   440 APSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHA 504
                               :.|.|:|||.|..|.||.|.|..:||...|.:..|.|:.|.|:..|
Human   288 -------------------LQCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSGNTCEACNCHNKA 333

  Fly   505 RRCRFNLELYKLSGRVS-------GGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCD 562
            :.|.::..:.|....::       ||||.||..:|.|..|..|.:||||.....|...:.|:.|:
Human   334 KDCYYDESVAKQKKSLNTAGQFRGGGVCINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCN 398

  Fly   563 CHPVGSTGKTC-----------NHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNAN 616
            |.||||....|           ....||||||||.||..|:||..||:.          .||
Human   399 CDPVGSLSSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQLGYKD----------YPT--- 450

  Fly   617 MIQAESAGGGGGGGTGDYKDGGGSQVEE--MKKYCGKCKASPKKLNLNK---------FC 665
               ..|.|....|...|....|....:|  ..|.|.:||  |...||.:         ||
Human   451 ---CVSCGCNPVGSASDEPCTGPCVCKENVEGKACDRCK--PGFYNLKEKNPRGCSECFC 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	57/246 (23%)
		EGF_Lam	<458..484	CDD:238012	11/25 (44%)
		EGF_Lam	498..555	CDD:238012	20/63 (32%)
		EGF_Lam	560..608	CDD:238012	22/58 (38%)
		NTR_netrin-1_like	661..791	CDD:239634	3/14 (21%)
LAMA1	NP_005550.2	LamNT	16..268	CDD:214532	73/388 (19%)
		EGF_Lam	270..317	CDD:238012	23/82 (28%)
		Laminin_EGF	397..456	CDD:278482	25/74 (34%)
		Laminin_EGF	454..500	CDD:278482	12/47 (26%)
		Laminin_B	568..696	CDD:278481
		EGF_Lam	741..789	CDD:238012
		Laminin_EGF	791..846	CDD:278482
		EGF_Lam	848..900	CDD:238012
		Laminin_EGF	902..948	CDD:278482
		Laminin_EGF	951..998	CDD:278482
		Laminin_EGF	998..1041	CDD:278482
		Laminin_EGF	1044..1092	CDD:278482
		Laminin_EGF	1090..1147	CDD:278482
		LamB	1213..1344	CDD:214597
		Laminin_EGF	1403..1449	CDD:278482
		Laminin_EGF	1452..1506	CDD:278482
		Laminin_EGF	1509..1556	CDD:278482
		Laminin_I	1567..1830	CDD:283627
		BAR	1609..1841	CDD:299863
		Laminin_II	2011..2145	CDD:283628
		LamG	2141..2280	CDD:214598
		LamG	2307..2463	CDD:238058
		Laminin_G_1	2514..2658	CDD:278483
		Laminin_G_1	2743..2872	CDD:278483
		LamG	2892..3043	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910