Protein Alignment NetB and Lamb2

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_037106.1
• Gene: Lamb2 / 25473
• RGDID: 2988
• Length: 1801
• Species: Rattus norvegicus
• Alignment Length: 663
• Identity: 164/663 - (24%)
• Similarity: 244/663 - (36%)
• Gaps: 225/663 - (33%)

  Fly     8 RMGLLLPIILALAIGSSAAGISSND-PCYFEGKPRKCLPSFVNAAYG--NPVQASSVCGAQQPER 69
            |:||||.::.|     :.|.:.|.| |....|   .|.|:..:...|  :.:.|||.||...|:.
  Rat    22 RLGLLLSVLAA-----TLAQVPSLDVPGCSRG---SCYPATGDLLVGRADRLTASSTCGLHSPQP 78

  Fly    70 YCELLRDGNAGECRSCEQQRYGPAALTDLNN------------PSNVTCWRSGAVNVPHDPDSAP 122
            ||.:....:..:|..|:.:|  |.:..|..|            |...|.|......||
  Rat    79 YCIVSHLQDEKKCFLCDSRR--PFSARDNPNSHRIQNVVTSFAPQRRTAWWQSENGVP------- 134

  Fly   123 PDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQC-QKFYGRP-- 184
              .||:.|.|..::..|::.::|  ::.||.::.:.:|:|||:||:.::::|..| ..|.|.|
  Rat   135 --MVTIQLDLEAEFHFTHLIMTF--KTFRPAAMLVERSADFGRTWRVYRYFSYDCGADFPGIPLA 195

  Fly   185 ------DRAKISKFNEQEARCINSQHDTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIR 243
                  |....|:::|.|.                   :.||......||.::.:.|..::
  Rat   196 PPRRWDDVVCESRYSEIEP-------------------STEGEVIYRVLDPAIPIPDPYSS---- 237

  Fly   244 VVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEY 308
                |::   .|||:.|.......:                        :.|.||         .
  Rat   238 ----RIQ---NLLKITNLRVNLTRL------------------------HTLGDN---------L 262

  Fly   309 EEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTP 373
            .:|::.:.                             ||:|
  Rat   263 LDPRREIR-----------------------------EKYY------------------------ 274

  Fly   374 PSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTP 438
                                ||:.:..:.|.|.|.||||:|.                    ..|
  Rat   275 --------------------YALYELVIRGNCFCYGHASQCA--------------------PAP 299

  Fly   439 SAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGH 503
            .||:.|         ...:...|.|||||.|..||:|:.||.|.||..|.|...:.|:.|:||||
  Rat   300 GAPAHA---------EGMVHGACICKHNTRGLNCEQCQDFYQDLPWHPAEDGHTHACRKCECNGH 355

  Fly   504 ARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGS 568
            :..|.|::.:|..||.||||||..|||:|.||:|..||..:|||.||.......|:.|||.|:||
  Rat   356 SHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDMRDPAACRPCDCDPMGS 420

  Fly   569 T--GKTCNH-------LSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNANMIQAESAG 624
            .  |:..:|       :||||.|||.|.|..|.:|..|:      .......|......|..|.|
  Rat   421 QDGGRCDSHDDPVLGLVSGQCRCKEHVVGTRCQQCRDGF------FGLSASNPRGCQRCQCNSRG 479

  Fly   625 GGGGGGTGDYKDG 637
            ...||...|...|
  Rat   480 TVPGGTPCDSSSG 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	55/246 (22%)
		EGF_Lam	<458..484	CDD:238012	13/25 (52%)
		EGF_Lam	498..555	CDD:238012	30/56 (54%)
		EGF_Lam	560..608	CDD:238012	20/56 (36%)
		NTR_netrin-1_like	661..791	CDD:239634
Lamb2	NP_037106.1	Laminin_N	50..284	CDD:459653	64/382 (17%)
		EGF_Lam	286..338	CDD:238012	26/80 (33%)
		EGF_Lam	350..402	CDD:238012	28/51 (55%)
		Laminin_EGF	413..470	CDD:395007	21/62 (34%)
		EGF_Lam	472..523	CDD:238012	7/21 (33%)
		EGF_Lam	524..565	CDD:238012
		EGF_Lam	786..831	CDD:214543
		Laminin_EGF	834..882	CDD:395007
		Laminin_EGF	880..927	CDD:395007
		EGF_Lam	929..987	CDD:238012
		Laminin_EGF	989..>1031	CDD:395007
		Laminin_EGF	1041..1095	CDD:395007
		Laminin_EGF	1098..1146	CDD:395007
		Laminin_EGF	1146..1193	CDD:395007
		Domain II	1193..1412
		Domain alpha	1413..1445
		Domain I	1446..1801
		Smc	<1448..>1793	CDD:440809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1684..1703
		cc_LAMB2_C	1730..1801	CDD:411970