Protein Alignment NetB and Ntn5

DIOPT Version :9

• Sequence 1: NP_001162753.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: XP_006540948.1
• Gene: Ntn5 / 243967
• MGIID: 2685330
• Length: 523
• Species: Mus musculus
• Alignment Length: 804
• Identity: 196/804 - (24%)
• Similarity: 271/804 - (33%)
• Gaps: 345/804 - (42%)

  Fly    14 PIILALAIGSSAAGISSNDPCYFE-GKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRDG 77
            ||.|:|.:..|.|   ::||||.. |:||.|||         ||
Mouse    20 PITLSLLLLLSQA---TSDPCYDPGGRPRFCLP---------PV--------------------- 51

  Fly    78 NAGECRSCEQQRYGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYIS 142
                     .|..|.||.     |.:.||....|       ...|..|.:|||.|...:.||.::
Mouse    52 ---------TQLVGKAAA-----PCSQTCALPAA-------SPGPACNSSLTLDLDGSFLLTSVT 95

  Fly   143 LSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHDTG 207
            |.||  :..|.:|.:..:...|..|:|          .:.||
Mouse    96 LRFC--TAGPPALVLSAAWATGGPWRP----------LWRRP----------------------- 125

  Fly   208 GAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSR 272
                                                                   |:...:||
Mouse   126 -------------------------------------------------------AWPGALGG-- 133

  Fly   273 EEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQ 337
                                                                             
Mouse   134 ----------------------------------------------------------------- 133

  Fly   338 GKHKGSAYEKHYQSKLAATTPPQQPPKVT---PPGKVTPPSTAAPSAAASAVTLPISQHYAVSDF 399
                                    |.|||   |||    |.|   ...||.:.:.......:...
Mouse   134 ------------------------PKKVTFHSPPG----PKT---RIVASYLRVEFGGKAGLVTT 167

  Fly   400 AVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACK 464
            .|.|||:|:|||:.|.                     |.:.|.                 .|.|:
Mouse   168 GVRGRCQCHGHAARCA---------------------TRAQPP-----------------RCRCR 194

  Fly   465 HNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQ 529
            |:|.||.||.|:|.:.|.||..||....:.|..|.||.||||||||.||::|||..|||||..|:
Mouse   195 HHTTGPGCESCRPSHRDWPWRPATPQHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCR 259

  Fly   530 HDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRC 594
            |.|.||:||||:.|::||.::|....|.|:.|.|||:|:||..||..||||.||.||||||||||
Mouse   260 HHTAGRHCHYCQPGFWRDPSQPITSHKACRACQCHPIGATGGMCNQTSGQCSCKLGVTGLTCNRC 324

  Fly   595 ARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEE--------------- 644
            ..||||:||...||          |.||.             |..|::.|
Mouse   325 GPGYQQSRSPRMPC----------QRESY-------------GTRSRIPEATTTPATTPVASRSD 366

  Fly   645 --MKKYCGKCKASPKKLNLNKFCMEDYAILAKVIGHDRASQDISTEKFSIERQNEIYKYEINIQT 707
              .:.|| ....|...::|.::|.:||.:.|:|    .||....:|...    .|.::..:::..
Mouse   367 PQCQGYC-NVSVSSVHMSLQRYCQQDYVLHAQV----SASSSQPSEAVG----PEWWRLAVHVLA 422

  Fly   708 IFKRNPMSGTTSSLLGRGNMMLLVPRKSIECQCPKIKLNKSYLILGR------DSEAAPGYLAIG 766
            :||:....      :.||.....|||..:.|.|.:::....||:|||      |....|..|.:.
Mouse   423 VFKQRAWP------VRRGGQEAWVPRADLICGCLRLRPGADYLLLGRAAQTHDDDNYDPARLILN 481

  Fly   767 PSSVVLEWKDEWSLRMKRFQRRAR 790
            ...:.|.|:..|:..::|.|::.|
Mouse   482 RHGLALPWRPRWARPLRRLQQKER 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	34/224 (15%)
		EGF_Lam	<458..484	CDD:238012	11/25 (44%)
		EGF_Lam	498..555	CDD:238012	34/56 (61%)
		EGF_Lam	560..608	CDD:238012	31/47 (66%)
		NTR_netrin-1_like	661..791	CDD:239634	33/136 (24%)
Ntn5	XP_006540948.1	EGF_Lam	172..216	CDD:238012	22/81 (27%)
		EGF_Lam	227..281	CDD:238012	33/53 (62%)
		EGF_Lam	290..339	CDD:238012	33/58 (57%)
		NTR_netrin-1_like	384..509	CDD:239634	33/136 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9271
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.870