DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetB and Ushbp1

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_852083.2	Gene:	Ushbp1 / 234395	MGIID:	1922920	Length:	680	Species:	Mus musculus

Alignment Length:	305	Identity:	65/305 - (21%)
Similarity:	99/305 - (32%)	Gaps:	93/305 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 DSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGR 183
            :::||   |..|..|::...:  |.|...|.|                |.|..  ||....|..|
Mouse   216 EASPP---TPILRAGRRNSNS--STSGAERRP----------------WVPQD--SSMAHPFLQR 257

  Fly   184 PDRAKISKFNEQEARCINSQH---------DTGGAAQ----------RFAFNTLEG-RPSANDLD 228
                ..|..:.|...|:::||         |..|..|          |.....|:| :.....|.
Mouse   258 ----LRSDSSTQSFGCLSTQHPAPETYLMEDQMGQLQGSIEKLKCFNRLLLAVLQGYKGRCESLS 318

  Fly   229 SSLVLQDWVTATDIRVVFHRL----ELPPQLLKVKNANAFSDEMG---GSREEDEDDDADLELDG 286
            ..|..:: ..||.:|:.....    |:...||.:|.|.     :|   |:.:.|        |..
Mouse   319 IKLAKRE-AEATALRLALQYSEDCEEVYEVLLALKMAG-----LGTGVGTTKGD--------LQA 369

  Fly   287 EQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGS---AYEKH 348
            .:.|....|...::.    .|.|.|:.             :|:|..|.|...:...|   .|.:|
Mouse   370 AEKEASRLLMKKEAT----MEVETPQP-------------SSEGSGVDKPTPEELASQLHGYVQH 417

  Fly   349 YQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAV----TLP 389
            .:.:.|....|::...||.| |.|.|...|...|...:    |||
Mouse   418 LRERWALVKIPEELGPVTAP-KATMPHAEATVQAILEIQPGPTLP 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	35/165 (21%)
		EGF_Lam	<458..484	CDD:238012
		EGF_Lam	498..555	CDD:238012
		EGF_Lam	560..608	CDD:238012
		NTR_netrin-1_like	661..791	CDD:239634
Ushbp1	NP_852083.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..161
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..247		10/47 (21%)
		MCC-bdg_PDZ	288..352	CDD:287477	12/64 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..405		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..549
		BAR	<585..>655	CDD:299863
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900