Protein Alignment NetB and Lamc1

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_034813.2
• Gene: Lamc1 / 226519
• MGIID: 99914
• Length: 1607
• Species: Mus musculus
• Alignment Length: 714
• Identity: 221/714 - (30%)
• Similarity: 310/714 - (43%)
• Gaps: 238/714 - (33%)

  Fly    10 GLLLPIILALAIGSSAAGI--SSNDPCYFE-GKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYC 71
            |.|.|::..||   :.||.  ::.|.|..| |:|::|:|.|||||:...|.|::.||. .||.||
Mouse    15 GRLWPLLAVLA---AVAGCVRAAMDECADEGGRPQRCMPEFVNAAFNVTVVATNTCGT-PPEEYC 75

  Fly    72 ELLRDGNAGECRSCE-----QQ--RYGPAALTDLNNPSNVTCWRSGAV--NVPHDPDSAPPDNVT 127
              ::.|..|..:||.     ||  ::|.|.|||.||.::.|.|:|..:  .|.:      |:::.
Mouse    76 --VQTGVTGVTKSCHLCDAGQQHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQY------PNSIN 132

  Fly   128 LTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKI-SK 191
            |||.|||.:::||:.|.|  .:.||:|.||:|.:.....|.|:|:||..|:..|.:.:|..| :.
Mouse   133 LTLHLGKAFDITYVRLKF--HTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTG 195

  Fly   192 FNEQEARCINSQHD----TGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELP 252
            .:||:|.|.:...|    |||   ..||:||||||||.:.|:|.|||:|||||||||..:||
Mouse   196 GDEQQALCTDEFSDISPLTGG---NVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRL--- 254

  Fly   253 PQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLEL 317
                     |.|.||:                                       :.:||
Mouse   255 ---------NTFGDEV---------------------------------------FNDPK----- 266

  Fly   318 DDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAA 382
                           |:|
Mouse   267 ---------------VLK----------------------------------------------- 269

  Fly   383 ASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHF 447
                    |.:||:|||||||||||||||||||                            .|.|
Mouse   270 --------SYYYAISDFAVGGRCKCNGHASECV----------------------------KNEF 298

  Fly   448 GRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLE 512
            .:         :.|.|||||.|.:||:|.||:.||||.|||...|:||..|.|||.::.|.|:.|
Mouse   299 DK---------LMCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPE 354

  Fly   513 LYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLS 577
            ||:.:|.  ||.|.||:.:|.|..|..|||.::|     ..:.:.|..|.|.||||....|:..
Mouse   355 LYRSTGH--GGHCTNCRDNTDGAKCERCRENFFR-----LGNTEACSPCHCSPVGSLSTQCDSY- 411

  Fly   578 GQCPCKEGVTGLTCNRCARGYQQ-TRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQ 641
            |:|.||.||.|..|:||..|:.. |.:...||...|:               |.|.:.....|..
Mouse   412 GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPS---------------GSTDECNVETGRC 461

  Fly   642 V--EEMKKY-CGKCKASPKKLNLNK---------FCMEDYAILAKVIGHDRASQDISTEKFSIE 693
            |  :.::.: |.:||  |...||..         ||....::....:|:  :..|||: .|.|:
Mouse   462 VCKDNVEGFNCERCK--PGFFNLESSNPKGCTPCFCFGHSSVCTNAVGY--SVYDISS-TFQID 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	95/238 (40%)
		EGF_Lam	<458..484	CDD:238012	14/25 (56%)
		EGF_Lam	498..555	CDD:238012	22/56 (39%)
		EGF_Lam	560..608	CDD:238012	19/48 (40%)
		NTR_netrin-1_like	661..791	CDD:239634	9/42 (21%)
Lamc1	NP_034813.2	Laminin_EGF	443..490	CDD:395007	12/63 (19%)
		LamB	551..676	CDD:214597
		Laminin_EGF	722..761	CDD:395007
		EGF_Lam	770..818	CDD:238012
		Laminin_EGF	826..873	CDD:395007
		Laminin_EGF	882..930	CDD:395007
		EGF_Lam	933..978	CDD:214543
		EGF_Lam	980..1027	CDD:238012
		Domain II and I	1029..1607
		Smc	<1033..>1570	CDD:440809
		LamNT	42..282	CDD:214532	110/379 (29%)
		EGF_Lam	283..328	CDD:238012	30/81 (37%)
		Laminin_EGF	340..394	CDD:395007	22/60 (37%)
		Laminin_EGF	396..443	CDD:395007	19/47 (40%)