DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and Ntn3

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_035077.1	Gene:	Ntn3 / 18209	MGIID:	1341188	Length:	580	Species:	Mus musculus

Alignment Length:	794	Identity:	274/794 - (34%)
Similarity:	359/794 - (45%)	Gaps:	246/794 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LALAIGSSAAGIS-----SNDPCYFEGK-PRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLR 75
            |.|..|:.:|.:|     |.||||.|.: ||.|:|..||||.|..|.|||.|| :...|.|:
Mouse     8 LLLTAGTLSAALSPGLPASADPCYDEAREPRSCIPGLVNAALGREVLASSTCG-RSANRVCD--- 68

  Fly    76 DGNAGECRSCEQQRYGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTY 140
                   .|..|:.:....||.....::..||||       |.....|.|||||:.|||.:||.:
Mouse    69 -------SSDPQRAHSADLLTSAPGTASPLCWRS-------DLLQQAPFNVTLTVPLGKAFELVF 119

  Fly   141 ISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGR-PDRAKISKFNEQEARCI---N 201
            :||.||  |..|.|:|:.||.|.|::|.|..|:||.|...||| |..|........||.|.   .
Mouse   120 VSLRFC--SAPPTSVALLKSQDHGRSWVPLGFFSSSCTLDYGRLPAPADGPSGPGPEALCFPAPQ 182

  Fly   202 SQHDTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSD 266
            :|.|.||.   .||:..:|.|...|||:|.||||||||||||:|..|    |.:
Mouse   183 AQPDGGGL---LAFSVQDGSPQGLDLDNSPVLQDWVTATDIRIVLTR----PAI----------- 229

  Fly   267 EMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGE 331
                                          ..|:.|.|
Mouse   230 ------------------------------QGDTRDGG--------------------------- 237

  Fly   332 SVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAV 396
                                                                  ||:|.|  |:.
Mouse   238 ------------------------------------------------------VTVPYS--YSA 246

  Fly   397 SDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTC 461
            ::..||||||||||||.|:                           |..| |.         :.|
Mouse   247 TELQVGGRCKCNGHASRCL---------------------------LDTH-GH---------LVC 274

  Fly   462 ACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCY 526
            .|:|.|.||:|.||||||.||||.|||..:|:.|..|.|||||||||||:|||:||||.|||||.
Mouse   275 DCQHGTEGPDCSRCKPFYCDRPWQRATGQEAHACLACSCNGHARRCRFNMELYRLSGRRSGGVCL 339

  Fly   527 NCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTC 591
            ||:|:|.||:|||||||:|||..:..:.|:.|:.|||||||:.|||||..:||||||:|||||||
Mouse   340 NCRHNTAGRHCHYCREGFYRDPGRVLSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTC 404

  Fly   592 NRCARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASP 656
            ||||.|:||:||.||||:|.|.                 .|..::....:.::.:.:|...:.|
Mouse   405 NRCAPGFQQSRSPVAPCVKTPV-----------------PGPTEESSPVEPQDCESHCRPARGS- 451

  Fly   657 KKLNLNKFCMEDYAILAKV--IGHDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTS 719
            .:::|.|||.:|||:...|  .|..|.|..               ::.:.:..:|:    ||...
Mouse   452 YRISLKKFCRKDYAVQVAVGARGEARGSWT---------------RFPVAVLAVFR----SGEER 497

  Fly   720 SLLGRGNMMLLVPRKSIECQCPKIKLNKSYLILGRDSEAAPGY-------LAIGPSSVVLEWKDE 777
            :  .||:..|.||.....|.||::...:.||:||....||.|.       |:....|:||.|:|.
Mouse   498 A--RRGSSALWVPTLDAACGCPRLLPGRRYLLLGGGPGAAAGSTAGRGQGLSAARGSLVLPWRDA 560

  Fly   778 WSLRMKRFQRRARK 791
            |:.|::|.|||.|:
Mouse   561 WTRRLRRLQRRERR 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	91/228 (40%)
		EGF_Lam	<458..484	CDD:238012	15/25 (60%)
		EGF_Lam	498..555	CDD:238012	40/56 (71%)
		EGF_Lam	560..608	CDD:238012	36/47 (77%)
		NTR_netrin-1_like	661..791	CDD:239634	41/138 (30%)
Ntn3	NP_035077.1	Laminin_N	34..253	CDD:295486	99/369 (27%)
		EGF_Lam	254..299	CDD:238012	30/81 (37%)
		Laminin_EGF	311..362	CDD:278482	40/50 (80%)
		EGF_Lam	373..422	CDD:238012	37/48 (77%)
		NTR_netrin-1_like	456..562	CDD:239634	35/126 (28%)
		Cell attachment site, atypical. /evidence=ECO:0000255	500..502		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837306
Domainoid	1	1.000	103	1.000	Domainoid score	I6769
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	617	1.000	Inparanoid score	I890
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48023
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104609
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.770