DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and lam-3

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_492775.2	Gene:	lam-3 / 172952	WormBaseID:	WBGene00002248	Length:	3102	Species:	Caenorhabditis elegans

Alignment Length:	720	Identity:	176/720 - (24%)
Similarity:	251/720 - (34%)	Gaps:	253/720 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RMGLLLPIILALAIG----SSAAGISSN---DPCYFE----GKPRKCLPSFVNAAYGNPVQASSV 61
            |:.|.|..:..:|:|    |..|.|..|   |..|.|    ...|...|:..|.|..:.:.|:..
Worm     2 RLWLGLLAVSNIALGGWNTSEDASIWENYVEDSNYHEFISSESERGLFPNIFNLATNSLITATDT 66

  Fly    62 CGAQQPERYCE-----LLRDGNAGECRSCEQQRYGPAALTDLNN-----PSNVTC------WRSG 110
            ||....|.||:     |||.....:...|:        :.|.||     |.....      |:|
Worm    67 CGQYTAEEYCKLVEHVLLRKTTNTQSPQCD--------ICDANNVHKRHPIEYAIDGTRRWWQS- 122

  Fly   111 AVNVPHDPDSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSS 175
                |...:....:.|.:|:.|.::|::.||.|.. ..||||.:..:.||.| |:.::|:|:|:.
Worm   123 ----PSLANGLRFEKVNITIDLRQEYQVAYIILKM-GNSPRPGTWVLEKSLD-GEYYEPWQYYAM 181

  Fly   176 Q---CQKFYGRPDRAKISKF-NEQEARCINSQHDTGGAAQRFAFNT--LEGRPSANDLDSSLVLQ 234
            |   |.:.:|.|....:.:| .|.|..| .|::......:....:|  :.|||.|.  ::||.||
Worm   182 QDAECMRQFGIPATTGVPRFQKEDEVHC-TSEYSKITPLENGEIHTSLVNGRPGAE--NTSLELQ 243

  Fly   235 DWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDND 299
            .:..|..:|:   ||..|..|                       :|||.:..::         :|
Worm   244 KFTRARFVRL---RLISPRTL-----------------------NADLMIINKK---------SD 273

  Fly   300 SADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPK 364
            |.|                            :||..|
Worm   274 SLD----------------------------KSVTMR---------------------------- 282

  Fly   365 VTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQ 429
                                       ..|::||.::||:|.|.|||..|.           ||.
Worm   283 ---------------------------YFYSISDISIGGQCICYGHAESCP-----------SDP 309

  Fly   430 DDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANE 494
            ..||                         ..|.|:|||.|..|.||.|.:...||...|::..|.
Worm   310 VTGQ-------------------------FKCECRHNTCGESCNRCCPLFNQLPWKPGTNSHPNV 349

  Fly   495 CKMCQCNGHARRCRFNLELYKLSGRVS-------GGVCYNCQHDTTGRYCHYCREGYYRDATKPP 552
            |:.|||..||..|.::.||.:....::       ||.|..|.|:|.|..|..|::||||.:....
Worm   350 CQQCQCFNHAHSCVYDDELDRNKWSITPEGVYEGGGRCLECAHNTEGFNCERCKDGYYRPSGLSH 414

  Fly   553 NHRKVCKRCDCHPVGSTGKTC---------NHLSGQCPCKEGVTGLTCNRCARGYQQTRSH--VA 606
            .....|:.|:|.||||....|         ....|.|.||.|..|..|.|||.||   |:|  ..
Worm   415 YREDACRTCECDPVGSVSDACVRDDQSAENGQKPGDCICKPGFGGRRCERCAPGY---RNHPTCE 476

  Fly   607 PCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQ----VEEMKKYCGKCKASPKKLNLNK---- 663
            ||   |.|.           .|....|..||...|    ||.:  ||.:|||....|:.:.
Worm   477 PC---PCNR-----------AGSVNFDTCDGASCQCKANVEGI--YCDRCKAGTIHLSASNPLGC 525

  Fly   664 ---FC 665
               ||
Worm   526 QPCFC 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	64/249 (26%)
		EGF_Lam	<458..484	CDD:238012	10/25 (40%)
		EGF_Lam	498..555	CDD:238012	21/63 (33%)
		EGF_Lam	560..608	CDD:238012	21/58 (36%)
		NTR_netrin-1_like	661..791	CDD:239634	2/12 (17%)
lam-3	NP_492775.2	LamNT	42..294	CDD:214532	75/387 (19%)
		EGF_Lam	296..343	CDD:238012	22/82 (27%)
		EGF_Lam	<384..411	CDD:214543	13/26 (50%)
		Laminin_EGF	423..480	CDD:278482	23/62 (37%)
		EGF_Lam	477..526	CDD:238012	17/64 (27%)
		LamB	583..711	CDD:214597
		EGF_Lam	774..818	CDD:238012
		Laminin_EGF	889..943	CDD:278482
		EGF_Lam	941..985	CDD:214543
		EGF_Lam	988..1033	CDD:214543
		EGF_Lam	1036..1083	CDD:214543
		Laminin_EGF	1086..1134	CDD:278482
		EGF_Lam	1133..1179	CDD:238012
		Laminin_EGF	1181..1229	CDD:278482
		Laminin_EGF	1227..1281	CDD:278482
		LamB	1341..1478	CDD:214597
		EGF_Lam	1539..1583	CDD:238012
		EGF_Lam	1590..1637	CDD:214543
		EGF_Lam	1646..1694	CDD:238012
		BAR	1848..2058	CDD:299863
		PspA	1864..2121	CDD:224755
		Laminin_II	2157..2286	CDD:283628
		LamG	2285..2443	CDD:214598
		LamG	2471..2622	CDD:238058
		LamG	2655..2821	CDD:238058
		LamG	2919..3065	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910