DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NetB and Lama3

DIOPT Version :9

Sequence 1:NP_001162753.1 Gene:NetB / 32400 FlyBaseID:FBgn0015774 Length:793 Species:Drosophila melanogaster
Sequence 2:XP_006525748.1 Gene:Lama3 / 16774 MGIID:99909 Length:3331 Species:Mus musculus


Alignment Length:648 Identity:143/648 - (22%)
Similarity:219/648 - (33%) Gaps:233/648 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LLLPIILALAIGSSAAGISSNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQ-------QPE 68
            |.|.::|.|.:..|.:.:..:.|.    ..|...|.:.|.|....:.|::.||.:       :||
Mouse    16 LTLLLLLLLRMSPSWSVVGQDHPM----SSRSLHPPYFNLAQAARIWATATCGERDPEVSRPRPE 76

  Fly    69 RYCELLRDGNAGE-------------CRSCEQQRYGPAALTDLNNPSNVTCWRSGAVNVPHDPDS 120
            .:|:|: .|.|.:             |.|.:.::..||               |.|::.......
Mouse    77 LFCKLV-GGPAAQGSGHTIQGQFCDYCNSEDSRKAHPA---------------SHAIDGSERWWQ 125

  Fly   121 APP-------DNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYS---S 175
            :||       :.|.|||.||:.:.:.||.:.|. .|||||...:.:|.|||.|:.|:|:::   .
Mouse   126 SPPLSSGTQYNQVNLTLDLGQLFHVAYILIKFA-NSPRPDLWILERSVDFGSTYSPWQYFAHSRR 189

  Fly   176 QCQKFYGRPDRAKISKFNEQEARCINSQH-----DTGGAAQRFAFNTLEGRPSANDLDSSLVLQD 235
            .|.:.:|:  .|.::...:.:..|:....     :.|    ....:.:.|||.|.....|..|::
Mouse   190 DCVEQFGQ--EANMAITQDDQMLCVTEYSRIVPLENG----EIVVSLINGRPGAKKFAFSDTLRE 248

  Fly   236 WVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDS 300
            :..||:||:.|.|            .|.....:....|.|                         
Mouse   249 FTKATNIRLRFLR------------TNTLLGHLISKAERD------------------------- 276

  Fly   301 ADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKV 365
                                                                          |.|
Mouse   277 --------------------------------------------------------------PTV 279

  Fly   366 TPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQD 430
            |.                       ..:|::.|.:|||||.|||||..|.|              
Mouse   280 TR-----------------------RYYYSIKDISVGGRCVCNGHAEACSA-------------- 307

  Fly   431 DGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANEC 495
                 |.|                 :....|.|:|:|.|..|.||...|..|.|..|.....|||
Mouse   308 -----DNP-----------------EKQFRCECQHHTCGDTCNRCCAGYNQRRWQPAGQEQHNEC 350

  Fly   496 KMCQCNGHARRCRFNLELYKLSGRVS-------GGVCYNCQHDTTGRYCHYCREGYYRDATKPPN 553
            :.|.|:|||..|.::.::......::       ||||.||||:|.|..|..|.:||:|....|.:
Mouse   351 EACNCHGHAVDCYYDPDVEHQQASLNSKGVYAGGGVCINCQHNTAGVNCEKCAKGYFRPHGVPVD 415

  Fly   554 HRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNAN 616
            ....|..|.|.|  .....|:..||.|.||...:|..|..||.||.    :...|:::|...|
Mouse   416 ALHGCIPCSCDP--ERADDCDQGSGHCHCKPNFSGDYCETCADGYY----NFPFCLRIPVFPN 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NetBNP_001162753.1 LamNT 37..261 CDD:214532 59/258 (23%)
EGF_Lam <458..484 CDD:238012 10/25 (40%)
EGF_Lam 498..555 CDD:238012 22/63 (35%)
EGF_Lam 560..608 CDD:238012 15/47 (32%)
NTR_netrin-1_like 661..791 CDD:239634
Lama3XP_006525748.1 LamNT 40..294 CDD:214532 68/398 (17%)
EGF_Lam 295..343 CDD:238012 22/83 (27%)
EGF_Lam 352..420 CDD:238012 22/67 (33%)
EGF_Lam 422..462 CDD:238012 15/45 (33%)
Laminin_EGF 488..535 CDD:365839
EGF_Lam 532..574 CDD:238012
Laminin_EGF 628..678 CDD:365839
EGF_Lam 681..724 CDD:238012
Laminin_EGF 1263..1311 CDD:365839
EGF_Lam 1308..1349 CDD:238012
Laminin_EGF 1353..1404 CDD:365839
EGF_Lam 1401..1451 CDD:238012
LamB 1509..1638 CDD:214597
EGF_Lam 1683..1729 CDD:238012
EGF_Lam 1731..1782 CDD:238012
Laminin_I 1844..2101 CDD:310534
SMC_prok_B <2062..>2329 CDD:274008
Laminin_II 2285..2413 CDD:368703
LamG 2432..2567 CDD:214598
LamG 2599..2739 CDD:238058
LamG 2766..2898 CDD:238058
LamG 2990..3132 CDD:238058
LamG 3156..3307 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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