DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and Lama1

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_032506.2	Gene:	Lama1 / 16772	MGIID:	99892	Length:	3083	Species:	Mus musculus

Alignment Length:	883	Identity:	185/883 - (20%)
Similarity:	301/883 - (34%)	Gaps:	331/883 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TGTRMGLLLPIILALAIGSSAAGISSNDPCYFEGKPRKCLPSFVNAAYGNPVQASSVCGAQQPER 69
            ||..:.:||..:|.:.:.|...|:               .|:.:|.|....:.|::.||.:.||.
Mouse     6 TGAALLVLLASVLWVTVRSQQRGL---------------FPAILNLATNAHISANATCGEKGPEM 55

  Fly    70 YCELL-----RDGNAGECRSCEQQRYGPA-------ALTDLNNPSNVTCWRSGAVNVPHDPDSAP 122
            :|:|:     |.....:||.|:.....|.       |:...||     .|:|     |...:...
Mouse    56 FCKLVEHVPGRPVRHAQCRVCDGNSTNPRERHPISHAIDGTNN-----WWQS-----PSIQNGRE 110

  Fly   123 PDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYS---SQCQKFYG-R 183
            ...||:||.|.:.:::.||.:. ...:|||.:..:.:|.| |..::|:|:|:   ::|...|. .
Mouse   111 YHWVTVTLDLRQVFQVAYIIIK-AANAPRPGNWILERSVD-GVKFKPWQYYAVSDTECLTRYKIT 173

  Fly   184 PDRAKISKFNEQEARC-------INSQHDTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATD 241
            |.|...:...:.|..|       :..:|.      ....:.:.|||||:|....|:  ::.:|..
Mouse   174 PRRGPPTYRADNEVICTSYYSKLVPLEHG------EIHTSLINGRPSADDPSPQLL--EFTSARY 230

  Fly   242 IRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYD 306
            ||:         :|.:::..|                 |||.....:|     |:|.|
Mouse   231 IRL---------RLQRIRTLN-----------------ADLMTLSHRD-----LRDLD------- 257

  Fly   307 EYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKV 371
                                     .:|.|:
Mouse   258 -------------------------PIVTRR---------------------------------- 263

  Fly   372 TPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDED 436
                                .:|::.|.:|||.|.|.||||.|                 ..||:
Mouse   264 --------------------YYYSIKDISVGGMCICYGHASSC-----------------PWDEE 291

  Fly   437 TPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCN 501
            ...                   :.|.|:|||.|..|:||.|.|..:||...|.:..|||:.|.|:
Mouse   292 AKQ-------------------LQCQCEHNTCGESCDRCCPGYHQQPWRPGTISSGNECEECNCH 337

  Fly   502 GHARRCRFNLELYK------LSGRVS-GGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCK 559
            ..|:.|.::..:.|      .:|:.| ||||.||..:|||..|..|.:.|||.....|.....|:
Mouse   338 NKAKDCYYDSSVAKERRSLNTAGQYSGGGVCVNCSQNTTGINCETCIDQYYRPHKVSPYDDHPCR 402

  Fly   560 RCDCHPVGSTGKTC----NHLS-------GQCPCKEGVTGLTCNRCARGYQQTRSHVA------- 606
            .|:|.||||....|    .|..       |||||::|..|..|:||..||:...:.:.
Mouse   403 PCNCDPVGSLSSVCIKDDRHADLANGKWPGQCPCRKGYAGDKCDRCQFGYRGFPNCIPCDCRTVG 467

  Fly   607 -----PCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKC-------------K 653
                 |||:.......::        |......|.|..:..|...:.|.:|             .
Mouse   468 SLNEDPCIEPCLCKKNVE--------GKNCDRCKPGFYNLKERNPEGCSECFCFGVSGVCDSLTW 524

  Fly   654 ASPKKLNLNKFCMEDYAILAKVIGHDRASQDI--STEKFSI------ERQNEIY----------- 699
            :..:..|::.:.:.|.....|:    |:.||:  ...:.||      :|....|
Mouse   525 SISQVTNMSGWLVTDLMSTNKI----RSQQDVLGGHRQISINNTAVMQRLTSTYYWAAPEAYLGN 585

  Fly   700 -------------KYEINIQT-----------IFKRNPMSGTTSSLLGRG----------NMMLL 730
                         .|:|.::|           |.|.|   |.|.|....|          |::.|
Mouse   586 KLTAFGGFLKYTVSYDIPVETVDSDLMSHADIIIKGN---GLTISTRAEGLSLQPYEEYFNVVRL 647

  Fly   731 VP--------RKSIE-CQCPKIKLNKSYLILGRDSEAA 759
            ||        |:.|: .|...:..|.::|::..:..:|
Mouse   648 VPENFRDFDTRREIDRDQLMTVLANVTHLLIRANYNSA 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	55/246 (22%)
		EGF_Lam	<458..484	CDD:238012	11/25 (44%)
		EGF_Lam	498..555	CDD:238012	22/63 (35%)
		EGF_Lam	560..608	CDD:238012	20/70 (29%)
		NTR_netrin-1_like	661..791	CDD:239634	29/161 (18%)
Lama1	NP_032506.2	LamNT	25..275	CDD:214532	69/401 (17%)
		EGF_Lam	277..324	CDD:238012	22/82 (27%)
		Laminin_EGF	404..463	CDD:278482	20/58 (34%)
		Laminin_EGF	461..507	CDD:278482	7/53 (13%)
		Laminin_B	575..714	CDD:306547	20/114 (18%)
		EGF_Lam	748..796	CDD:238012
		Laminin_EGF	798..853	CDD:278482
		EGF_Lam	855..907	CDD:238012
		Laminin_EGF	909..955	CDD:278482
		EGF_Lam	958..1002	CDD:214543
		EGF_Lam	1004..1049	CDD:238012
		Laminin_EGF	1051..1099	CDD:278482
		Laminin_EGF	1097..1154	CDD:278482
		Cell attachment site	1147..1149
		Laminin_B	1225..1367	CDD:306547
		Laminin_EGF	1410..1456	CDD:278482
		Laminin_EGF	1459..1513	CDD:278482
		EGF_Lam	1516..>1553	CDD:238012
		Domain II and I	1564..2123
		Laminin_I	1582..1837	CDD:310534
		DUF390	<1827..>2064	CDD:330463
		Laminin_II	2018..2152	CDD:283628
		LamG	2136..2285	CDD:238058
		LamG	2314..2470	CDD:238058
		LamG	2495..2659	CDD:238058
		Laminin_G_1	2751..2880	CDD:278483
		LamG	2900..3053	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910