Protein Alignment NetB and NTN5

DIOPT Version :9

• Sequence 1: NP_001162753.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_665806.1
• Gene: NTN5 / 126147
• HGNCID: 25208
• Length: 489
• Species: Homo sapiens
• Alignment Length: 785
• Identity: 183/785 - (23%)
• Similarity: 272/785 - (34%)
• Gaps: 321/785 - (40%)

  Fly    13 LPIILALAIGSSAAGISSNDPCYF-EGKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLRD 76
            :|:..||.:   ..|.::.||||. :|:|:.|||         ||...:...|..|:. |.|...
Human     1 MPVTFALLL---LLGQATADPCYDPQGRPQFCLP---------PVTQLAAVAASCPQA-CALSPG 52

  Fly    77 GNAGECRSCEQQRYGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYI 141
            .:.|...:|                                       |.:|||:||..:.||.:
Human    53 NHLGARETC---------------------------------------NGSLTLALGGPFLLTSV 78

  Fly   142 SLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQEARCINSQHDT 206
            ||.||  :|.|.:|.:..:...|..|
Human    79 SLRFC--TPGPPALILSAAWASGGPW--------------------------------------- 102

  Fly   207 GGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFSDEMGGS 271
                                                |:::||
Human   103 ------------------------------------RLLWHR----------------------- 108

  Fly   272 REEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKR 336
                                                                             
Human   109 ----------------------------------------------------------------- 108

  Fly   337 QGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSA--AASAVTLPISQHYAVSDF 399
                                  |..|..:..|.:||..||..|.|  |||.:.:.......::..
Human   109 ----------------------PAWPGALGGPERVTFHSTPGPKATVAASHLRVEFGGQAGLAAA 151

  Fly   400 AVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMTCACK 464
            .:.|||:|:|||:.|.|.                     :.|.                 .|.|:
Human   152 GLRGRCQCHGHAARCAAR---------------------ARPP-----------------RCHCR 178

  Fly   465 HNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVCYNCQ 529
            |:|.||.||.|:|.:.|.||..||....:.|..|.||.||||||||.||::|||..|||||..|:
Human   179 HHTTGPGCESCRPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCR 243

  Fly   530 HDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLTCNRC 594
            |.|.||:||||:.|::||.::|...|:.|:.|.|||:|:||.|||..||||.||.||||||||||
Human   244 HHTAGRHCHYCQPGFWRDPSQPIFSRRACRACQCHPIGATGGTCNQTSGQCTCKLGVTGLTCNRC 308

  Fly   595 ARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKASPKKL 659
            ..||||:||...||.::|.....:..              ..|..|...:.:.|| ....:...:
Human   309 GPGYQQSRSPRMPCQRIPEATTTLAT--------------TPGAYSSDPQCQNYC-NMSDTRVHM 358

  Fly   660 NLNKFCMEDYAILAKVIGHDRAS---QDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSSL 721
            :|.::|.:|:.:.|:|:..:.|.   |.::....::.:|              :..|:.
Human   359 SLRRYCQQDHVLRAQVLASEAAGPAWQRLAVRVLAVYKQ--------------RAQPVR------ 403

  Fly   722 LGRGNMMLLVPRKSIECQCPKIKLNKSYLILGRD-SEAAPGYLAIGPSSVVLEWKDEWSLRMKRF 785
              ||:....|||..:.|.|.:::....||:||.. .:..|..|.:....:.|.|:..|:..:||.
Human   404 --RGDQDAWVPRADLTCGCLRLQPGTDYLLLGSAVGDPDPTRLILDRHGLALPWRPRWARPLKRL 466

  Fly   786 QRRAR 790
            |:..|
Human   467 QQEER 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	33/223 (15%)
		EGF_Lam	<458..484	CDD:238012	11/25 (44%)
		EGF_Lam	498..555	CDD:238012	34/56 (61%)
		EGF_Lam	560..608	CDD:238012	32/47 (68%)
		NTR_netrin-1_like	661..791	CDD:239634	29/134 (22%)
NTN5	NP_665806.1	EGF_Lam	211..265	CDD:238012	33/53 (62%)
		EGF_Lam	274..323	CDD:238012	33/48 (69%)
		NTR_netrin-1_like	360..475	CDD:239634	29/134 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	470..489		1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9319
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880