DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and Lamc1

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_446418.1	Gene:	Lamc1 / 117036	RGDID:	621052	Length:	1607	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	222/716 - (31%)
Similarity:	306/716 - (42%)	Gaps:	241/716 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RMGLLLPIILALAIGSSAAGISSNDPCYFE-GKPRKCLPSFVNAAYGNPVQASSVCGAQQPERYC 71
            |:.|||.::.|:|....||    .|.|..| |:|::|:|.|||||:...|.|::.||. .||.||
  Rat    16 RLWLLLAVLAAVACWVRAA----MDECADEGGRPQRCMPEFVNAAFNVTVVATNTCGT-PPEEYC 75

  Fly    72 ELLRDGNAGECRSCE-------QQRYGPAALTDLNNPSNVTCWRSGAV--NVPHDPDSAPPDNVT 127
              ::.|..|..:||.       ..::|.|.|||.||.::.|.|:|..:  .|.:      |:::.
  Rat    76 --VQTGVTGVTKSCHLCDAGQLHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQY------PNSIN 132

  Fly   128 LTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKI-SK 191
            |||.|||.:::||:.|.|  .:.||:|.||:|.:.....|.|:|:||..|:..|.:.:|..| :.
  Rat   133 LTLHLGKAFDITYVRLKF--HTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTG 195

  Fly   192 FNEQEARCINSQHD----TGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELP 252
            .:||:|.|.:...|    |||   ..||:||||||||.:.|:|.|||:|||||||||..:||
  Rat   196 GDEQQALCTDEFSDISPLTGG---NVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRL--- 254

  Fly   253 PQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLEL 317
                     |.|.||:                                       :.:||
  Rat   255 ---------NTFGDEV---------------------------------------FNDPK----- 266

  Fly   318 DDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAA 382
                           |:|
  Rat   267 ---------------VLK----------------------------------------------- 269

  Fly   383 ASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHF 447
                    |.:||:|||||||||||||||||||                            .|.|
  Rat   270 --------SYYYAISDFAVGGRCKCNGHASECV----------------------------KNEF 298

  Fly   448 GRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLE 512
            |:         :.|.|||||.|.:||:|.||:.||||.|||...||:|..|.|||.::.|.|:.|
  Rat   299 GK---------LVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESANQCLPCDCNGRSQECYFDPE 354

  Fly   513 LYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLS 577
            ||:.:|.  ||.|.||:.:|.|..|..|||.::|     ..:.:.|..|.|.||||....|:..
  Rat   355 LYRSTGH--GGHCTNCRDNTDGAKCERCRENFFR-----LGNTEACSPCHCSPVGSLSTQCDSY- 411

  Fly   578 GQCPCKEGVTGLTCNRCARGYQQ-TRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGG-- 639
            |:|.||.||.|..|:||..|:.. |.:...||...|:               |.|.:.....|
  Rat   412 GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPS---------------GSTDECNVETGRC 461

  Fly   640 ---SQVEEMKKYCGKCKASPKKLNLNK---------FCMEDYAILAKVIGHDRASQDISTEKFSI 692
               ..||...  |.:||  |...||..         ||....::....:|:  :..|||: .|.|
  Rat   462 VCKDNVEGFS--CERCK--PGFFNLESSNPKGCTPCFCFGHSSVCTNAVGY--SVYDISS-TFQI 519

  Fly   693 E 693
            :
  Rat   520 D 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	93/238 (39%)
		EGF_Lam	<458..484	CDD:238012	14/25 (56%)
		EGF_Lam	498..555	CDD:238012	22/56 (39%)
		EGF_Lam	560..608	CDD:238012	19/48 (40%)
		NTR_netrin-1_like	661..791	CDD:239634	9/42 (21%)
Lamc1	NP_446418.1	LamNT	42..282	CDD:214532	108/379 (28%)
		EGF_Lam	283..328	CDD:238012	31/81 (38%)
		Laminin_EGF	340..394	CDD:278482	22/60 (37%)
		Laminin_EGF	396..443	CDD:278482	19/47 (40%)
		Laminin_EGF	443..490	CDD:278482	13/65 (20%)
		LamB	552..676	CDD:214597
		Laminin_EGF	722..761	CDD:278482
		EGF_Lam	770..818	CDD:238012
		Laminin_EGF	826..873	CDD:278482
		Laminin_EGF	882..930	CDD:278482
		EGF_Lam	933..978	CDD:214543
		EGF_Lam	980..1027	CDD:238012
		FlgN	<1048..1121	CDD:298847
		MA	1089..1300	CDD:214599
		Tropomyosin	1355..1586	CDD:278679
		Prefoldin	1416..1551	CDD:298833
		SPX	<1518..1588	CDD:271919
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.870