DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NetB and Ntn3

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_446184.1	Gene:	Ntn3 / 114524	RGDID:	619811	Length:	580	Species:	Rattus norvegicus

Alignment Length:	793	Identity:	269/793 - (33%)
Similarity:	356/793 - (44%)	Gaps:	244/793 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LALAIGSSAAGIS-----SNDPCYFEGK-PRKCLPSFVNAAYGNPVQASSVCGAQQPERYCELLR 75
            |.|..|:.:|.:|     |.||||.|.: ||.|.|..||||.|..|.|||.||  :|..:.
  Rat     8 LLLTAGTLSAALSPGLPASADPCYDEAREPRCCTPGLVNAALGREVLASSTCG--RPANHV---- 66

  Fly    76 DGNAGECRSCEQQR-YGPAALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELT 139
                  |...:.|| :....||.....::..||||       |.....|.|||||:.|||.:||.
  Rat    67 ------CDPSDPQRAHSADLLTSAPGTASPLCWRS-------DVLQRAPFNVTLTVPLGKAFELV 118

  Fly   140 YISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGR-PDRAKISKFNEQEARCI--- 200
            ::||.||  |..|.|:|:.||.|.|::|.|..|:||.|...||| |..|........||.|.
  Rat   119 FVSLRFC--SAPPTSVALLKSQDHGRSWVPLGFFSSSCSLDYGRLPAPADGPAGPGPEALCFPAP 181

  Fly   201 NSQHDTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNANAFS 265
            .:|.|.||.   .||:..:|.|...|||:|.||||||||||||:|..|    |.:
  Rat   182 QAQPDGGGL---LAFSVQDGSPQGLDLDNSPVLQDWVTATDIRIVLTR----PAI---------- 229

  Fly   266 DEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDG 330
                                           ..|:.|.|
  Rat   230 -------------------------------QGDTRDGG-------------------------- 237

  Fly   331 ESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYA 395
                                                                   ||:|.|  |:
  Rat   238 -------------------------------------------------------VTVPYS--YS 245

  Fly   396 VSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAKLTMT 460
            .::..||||||||||:|.|:                                     |.....:.
  Rat   246 ATELQVGGRCKCNGHSSRCL-------------------------------------MDTHGHLV 273

  Fly   461 CACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVSGGVC 525
            |.|:|.|.||:|.||||||.||||.|||..:|:.|..|.|||||||||||:|||:||||.|||||
  Rat   274 CDCQHGTEGPDCSRCKPFYCDRPWQRATGQEAHACLACSCNGHARRCRFNMELYRLSGRRSGGVC 338

  Fly   526 YNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHPVGSTGKTCNHLSGQCPCKEGVTGLT 590
            .||:|:|.||:|||||||:|||..:..:.|:.|:.|||||||:.|||||..:||||||:||||||
  Rat   339 LNCRHNTAGRHCHYCREGFYRDPGRVLSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLT 403

  Fly   591 CNRCARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKYCGKCKAS 655
            |||||.|:||:||.||||:|.|.                 .|..::....:.::.:.:|...:.|
  Rat   404 CNRCAPGFQQSRSPVAPCVKTPV-----------------PGPTEESSPVEPQDCESHCRPARGS 451

  Fly   656 PKKLNLNKFCMEDYAILAKVIGHDRASQDISTEKFSIERQNEIYKYEINIQTIFKRNPMSGTTSS 720
             .:::|.|||.:|||:...|....             |.:....::.:.:..:|:    ||...:
  Rat   452 -YRISLKKFCRKDYAVQVAVGARG-------------EARGAWTRFPVAVLAVFR----SGEERA 498

  Fly   721 LLGRGNMMLLVPRKSIECQCPKIKLNKSYLILGRDSEAAPGY-------LAIGPSSVVLEWKDEW 778
              .||:..|.||.....|.||:::..:.||:||....||.|.       |:....|:||.|:|.|
  Rat   499 --RRGSSALWVPTLDAACGCPRLQPGRRYLLLGDGPGAAAGSPAGRGPGLSAARGSLVLPWRDAW 561

  Fly   779 SLRMKRFQRRARK 791
            :.|::|.|||.|:
  Rat   562 TRRLRRLQRRERR 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	91/229 (40%)
		EGF_Lam	<458..484	CDD:238012	15/25 (60%)
		EGF_Lam	498..555	CDD:238012	40/56 (71%)
		EGF_Lam	560..608	CDD:238012	36/47 (77%)
		NTR_netrin-1_like	661..791	CDD:239634	39/136 (29%)
Ntn3	NP_446184.1	Laminin_N	34..253	CDD:295486	99/370 (27%)
		EGF_Lam	254..299	CDD:238012	27/81 (33%)
		Laminin_EGF	311..362	CDD:278482	40/50 (80%)
		EGF_Lam	373..422	CDD:238012	37/48 (77%)
		NTR_netrin-1_like	456..562	CDD:239634	33/124 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341026
Domainoid	1	1.000	103	1.000	Domainoid score	I6621
eggNOG	1	0.900	-	-		E1_KOG3512
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	611	1.000	Inparanoid score	I878
OMA	1	1.010	-	-		QHG48023
OrthoDB	1	1.010	-	-		D368755at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104609
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1381
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.770