Protein Alignment NetB and Ntn1

DIOPT Version :10

• Sequence 1: NP_511155.1
• Gene: NetB / 32400
• FlyBaseID: FBgn0015774
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_446183.2
• Gene: Ntn1 / 114523
• RGDID: 619809
• Length: 604
• Species: Rattus norvegicus
• Alignment Length: 813
• Identity: 328/813 - (40%)
• Similarity: 425/813 - (52%)
• Gaps: 237/813 - (29%)

  Fly     1 MVRATGTRMGLLLPIILALAIGSSAAGIS-------SNDPCYFE-GKPRKCLPSFVNAAYGNPVQ 57
            |:||....:..|..:...:.......|:|       ..|||..| |.||:|:|.|||||:|..|:
  Rat     1 MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVR 65

  Fly    58 ASSVCGAQQPERYCELLRDGNAGECRSCE-------QQRYGPAALTDLNNPSNVTCWRS-GAVNV 114
            .||.|| :.|.|||.:...|.. ..|||.       ::.:.||.|||||||.|:|||:| ..:..
  Rat    66 VSSTCG-RPPARYCVVSERGEE-RLRSCHLCNSSDPKKAHPPAFLTDLNNPHNLTCWQSENYLQF 128

  Fly   115 PHDPDSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQK 179
            ||        |||||||||||:|:||:||.||  ||||:|:||:||.|:|:||.||||||:||:|
  Rat   129 PH--------NVTLTLSLGKKFEVTYVSLQFC--SPRPESMAIYKSMDYGRTWVPFQFYSTQCRK 183

  Fly   180 FYGRPDRAKISKFNEQEARCINSQHD----TGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTAT 240
            .|.||.||.|:|.|||||.|.:|..|    :||.   .||:||:|||||:|.|:|.|||||||||
  Rat   184 MYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGL---IAFSTLDGRPSAHDFDNSPVLQDWVTAT 245

  Fly   241 DIRVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGY 305
            ||||.|.||            :.|.||        .:||::|..|
  Rat   246 DIRVAFSRL------------HTFGDE--------NEDDSELARD-------------------- 270

  Fly   306 DEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGK 370
                                                                             
  Rat   271 ----------------------------------------------------------------- 270

  Fly   371 VTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDE 435
                                |.:|||||..|||||||||||:.||           .|:||
  Rat   271 --------------------SYYYAVSDLQVGGRCKCNGHAARCV-----------RDRDD---- 300

  Fly   436 DTPSAPSLANHFGRSTQMSAKLTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQC 500
                                  ::.|.|:||||||||:|||||::||||.|||..:||||..|.|
  Rat   301 ----------------------SLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNC 343

  Fly   501 NGHARRCRFNLELYKLSGRVSGGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHP 565
            |.||||||||:||||||||.|||||.||:|:|.||:||||:||:|||..||..|||.||.|||||
  Rat   344 NLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDMGKPITHRKACKACDCHP 408

  Fly   566 VGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCIKVPTNANMIQAESAGGGGGGG 630
            ||:.|||||..:||||||:||||:||||||:||||:||.:|||||:|.......|.|.
  Rat   409 VGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSM------- 466

  Fly   631 TGDYKDGGGSQVEEMKKYCGKCKASPKKLNLNKFCMEDYAILAKVIGHDRASQDISTEKFSIERQ 695
                     .:.|:...|| |......|:|:.|:|.:|||:...::..|:|
  Rat   467 ---------EEPEDCDSYC-KASKGKLKMNMKKYCRKDYAVQIHILKADKA-------------- 507

  Fly   696 NEIYKYEINIQTIFKRNPMSGTTSSLLGRGNMMLLVPRKSIECQCPKIKLNKSYLILG--RDSEA 758
            .:.:|:.:||.:::|:    ||  |.:.||:..|.:..:.|.|:|||||..|.||:||  .||..
  Rat   508 GDWWKFTVNIISVYKQ----GT--SRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPD 566

  Fly   759 APGYLAIGPSSVVLEWKDEWSLRMKRFQRRARK 791
            ..|.:| ..||:|::|:|.|:.|:::||:|.:|
  Rat   567 QSGIVA-DKSSLVIQWRDTWARRLRKFQQREKK 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_511155.1	LamNT	37..261	CDD:214532	126/236 (53%)
		EGF_Lam	<458..484	CDD:238012	17/25 (68%)
		EGF_Lam	498..555	CDD:238012	41/56 (73%)
		EGF_Lam	560..608	CDD:238012	35/47 (74%)
		NTR_netrin-1_like	661..791	CDD:239634	43/131 (33%)
Ntn1	NP_446183.2	LamNT	46..283	CDD:214532	139/376 (37%)
		EGF_Lam	284..329	CDD:238012	32/81 (40%)
		Laminin_EGF	341..401	CDD:395007	44/59 (75%)
		Laminin_EGF	404..>441	CDD:395007	28/36 (78%)
		NTR_netrin-1_like	487..601	CDD:239634	44/133 (33%)
		Cell attachment site. /evidence=ECO:0000255	530..532		1/1 (100%)