DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NetB and LOC101885031

DIOPT Version :9

Sequence 1:	NP_001162753.1	Gene:	NetB / 32400	FlyBaseID:	FBgn0015774	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_005174519.2	Gene:	LOC101885031 / 101885031	-ID:	-	Length:	604	Species:	Danio rerio

Alignment Length:	733	Identity:	176/733 - (24%)
Similarity:	246/733 - (33%)	Gaps:	280/733 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IILALAIGSSAAGISSNDPCYFEGKPRKCLPSFVNAAYGNP--VQASSVCGAQQPERYCELLRDG 77
            |:|:||  :.:|..|:...|    :...|.|:..:...|..  ::|||.||....|..|     .
Zfish     5 ILLSLA--ALSAMCSAQQDC----RRGACYPAMDDLLLGREQNLRASSTCGLMGSEVVC-----S 58

  Fly    78 NAGE----CRSCEQQRYGPAALTDLNNPSNVTC-------WRSGAVNVPHDPDSAPPDNVTLTLS 131
            ..|:    |..|:.:  .|||. :.:...||..       |:|       ..|..|   |||.|.
Zfish    59 PHGQWKMKCCPCDSR--NPAAY-NAHTIQNVISSAGPNRWWQS-------KKDVNP---VTLQLD 110

  Fly   132 LGKKYELTYISLSFCPRSPRPDSLAIFKSSDFGQTWQPFQFYSSQCQKFYGRPDRAKISKFNEQE 196
            |..:|.|..:.|||  :.||||:|.|.:|.|:|::|||..:.::.|...:.|...:....|.|..
Zfish   111 LNGQYHLETVFLSF--KGPRPDALIIERSRDYGRSWQPVLYMATNCPSTFPRVSTSFPRSFEETY 173

  Fly   197 ARCINSQHDTGGAAQRFAFNTLEGRPSANDLDSSLVLQDWVTATDIRVVFHRLELPPQLLKVKNA 261
            ...:.|..|.....|:..|..|.                         .|..:.||.: .|::.|
Zfish   174 CYTLPSTADDPYKDQKIHFYPLR-------------------------QFADINLPNE-YKIEVA 212

  Fly   262 NAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDY 326
            :.|:    |.|                    .||
Zfish   213 SGFT----GLR--------------------VNL------------------------------- 222

  Fly   327 ASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPIS 391
                                            .|..|..:.||:                  .:|
Zfish   223 --------------------------------TQLGPVPSLPGR------------------GLS 237

  Fly   392 QHYAVSDFAVGGRCKCNGHASECVATVSSGSGTALSDQDDGQDEDTPSAPSLANHFGRSTQMSAK 456
            |:||:.:..|.|.|.|:|||:.|:                   :||      :|::..:|.:..
Zfish   238 QYYALREMKVIGSCFCHGHANRCL-------------------QDT------SNNYLPNTPVGG- 276

  Fly   457 LTMTCACKHNTAGPECERCKPFYFDRPWGRATDNDANECKMCQCNGHARRCRFNLELYKLSGRVS 521
               .|.|:|||||..|:||..||.|.||..|...:.:.||.|:||.|:.||.|:.|.|:.:||.|
Zfish   277 ---MCECQHNTAGVNCDRCDDFYNDLPWRPAESGNTHACKRCECNNHSERCHFDPERYEATGRSS 338

  Fly   522 GGVCYNCQHDTTGRYCHYCREGYYRDATKPPNHRKVCKRCDCHP--------------------- 565
            ||||..|.|.|||..|..|...||.:..........|.||.|.|
Zfish   339 GGVCDACAHHTTGPQCERCERNYYPNPLSDMRSADACLRCLCDPAGSENGGQCDAGTGVCVCKQN 403

  Fly   566 -------------------------------VGSTGKTCNHLSGQCPCKEGVTGLTCNRCARGY- 598
                                           |||....||.|:|||.|:..:.||:|:|||.||
Zfish   404 VEGERCDRCKAGFYNLNANNPLGCSKCSCSSVGSLSGVCNQLTGQCVCRSNMEGLSCDRCAAGYW 468

  Fly   599 -QQTRSHVAPCIKVPTNANMIQAESAGG------GGGGGT---------GDYKDG---------G 638
             ..:.|...||...|.||.....:...|      |.||.|         ||...|         |
Zfish   469 NPTSPSGCQPCGCDPDNARSATCDQRTGQCQCRPGNGGRTCSGCPDNTYGDPLIGCRRCDCDQLG 533

  Fly   639 GSQVEEMKKYCGKCKASP 656
               .|...|..|.|:..|
Zfish   534 ---TEACDKRTGVCRCKP 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NetB	NP_001162753.1	LamNT	37..261	CDD:214532	57/236 (24%)
		EGF_Lam	<458..484	CDD:238012	13/25 (52%)
		EGF_Lam	498..555	CDD:238012	25/56 (45%)
		EGF_Lam	560..608	CDD:238012	23/101 (23%)
		NTR_netrin-1_like	661..791	CDD:239634
LOC101885031	XP_005174519.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000